A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration Article Swipe
Friederike Grandke
,
Tobias Fehlmann
,
Fabian Kern
,
David Gate
,
Tobias William Wolff
,
Olivia Leventhal
,
Divya Channappa
,
Pascal Hirsch
,
Edward N. Wilson
,
Eckart Meese
,
Chuanyu Liu
,
Quan Shi
,
Matthias Flotho
,
Yongping Li
,
Cynthia Chen
,
Yeya Yu
,
Jiangshan Xu
,
Michael Junkin
,
Zhifeng Wang
,
Tao Wu
,
Longqi Liu
,
Yong Hou
,
Katrin I. Andreasson
,
Jennifer Gansen
,
Elvira Mass
,
Kathleen L. Poston
,
Tony Wyss‐Coray
,
Andreas Keller
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41467-025-56833-7
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41467-025-56833-7
The clinical course and treatment of neurodegenerative disease are complicated by immune-system interference and chronic inflammatory processes, which remain incompletely understood. Mapping immune signatures in larger human cohorts through single-cell gene expression profiling supports our understanding of observed peripheral changes in neurodegeneration. Here, we employ single-cell gene expression profiling of over 909k peripheral blood mononuclear cells (PBMCs) from 121 healthy individuals, 48 patients with mild cognitive impairment (MCI), 46 with Parkinson’s disease (PD), 27 with Alzheimer’s disease (AD), and 15 with both PD and MCI. The dataset is interactively accessible through a freely available website ( https://www.ccb.uni-saarland.de/adrcsc ). In this work, we identify disease-associated changes in blood cell type composition and the gene expression in a sex-specific manner, offering insights into peripheral and solid tissue signatures in AD and PD.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41467-025-56833-7
- https://www.nature.com/articles/s41467-025-56833-7.pdf
- OA Status
- gold
- References
- 86
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407938978
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4407938978Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41467-025-56833-7Digital Object Identifier
- Title
-
A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegenerationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-02-25Full publication date if available
- Authors
-
Friederike Grandke, Tobias Fehlmann, Fabian Kern, David Gate, Tobias William Wolff, Olivia Leventhal, Divya Channappa, Pascal Hirsch, Edward N. Wilson, Eckart Meese, Chuanyu Liu, Quan Shi, Matthias Flotho, Yongping Li, Cynthia Chen, Yeya Yu, Jiangshan Xu, Michael Junkin, Zhifeng Wang, Tao Wu, Longqi Liu, Yong Hou, Katrin I. Andreasson, Jennifer Gansen, Elvira Mass, Kathleen L. Poston, Tony Wyss‐Coray, Andreas KellerList of authors in order
- Landing page
-
https://doi.org/10.1038/s41467-025-56833-7Publisher landing page
- PDF URL
-
https://www.nature.com/articles/s41467-025-56833-7.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41467-025-56833-7.pdfDirect OA link when available
- Concepts
-
Neurodegeneration, Peripheral blood mononuclear cell, Gene expression profiling, Immune system, Disease, Gene expression, Cell, Gene, Cell type, Biology, Medicine, Bioinformatics, Neuroscience, Computational biology, Immunology, Pathology, Genetics, In vitroTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
-
86Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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