A single early-in-life antibiotic course increases susceptibility to DSS-induced colitis Article Swipe
Ceren Özkul
,
Victoria Ruiz
,
Thomas Battaglia
,
Joseph Xu
,
Claire Roubaud‐Baudron
,
Ken Cadwell
,
Guillermo I. Pérez‐Pérez
,
Martin J. Blaser
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1186/s13073-020-00764-z
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1186/s13073-020-00764-z
Background There is increasing evidence that the intestinal microbiota plays a crucial role in the maturation of the immune system and the prevention of diseases during childhood. Early-life short-course antibiotic use may affect the progression of subsequent disease conditions by changing both host microbiota and immunologic development. Epidemiologic studies provide evidence that early-life antibiotic exposures predispose to inflammatory bowel disease (IBD). Methods By using a murine model of dextran sodium sulfate (DSS)-induced colitis, we evaluated the effect on disease outcomes of early-life pulsed antibiotic treatment (PAT) using tylosin, a macrolide and amoxicillin, a beta-lactam. We evaluated microbiota effects at the 16S rRNA gene level, and intestinal T cells by flow cytometry. Antibiotic-perturbed or control microbiota were transferred to pups that then were challenged with DSS. Results A single PAT course early-in-life exacerbated later DSS-induced colitis by both perturbing the microbial community and altering mucosal immune cell composition. By conventionalizing germ-free mice with either antibiotic-perturbed or control microbiota obtained 40 days after the challenge ended, we showed the transferrable and direct effect of the still-perturbed microbiota on colitis severity in the DSS model. Conclusions The findings in this experimental model provide evidence that early-life microbiota perturbation may increase risk of colitis later in life.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s13073-020-00764-z
- https://genomemedicine.biomedcentral.com/track/pdf/10.1186/s13073-020-00764-z
- OA Status
- gold
- Cited By
- 45
- References
- 78
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3045021857Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1186/s13073-020-00764-zDigital Object Identifier
- Title
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A single early-in-life antibiotic course increases susceptibility to DSS-induced colitisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-07-25Full publication date if available
- Authors
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Ceren Özkul, Victoria Ruiz, Thomas Battaglia, Joseph Xu, Claire Roubaud‐Baudron, Ken Cadwell, Guillermo I. Pérez‐Pérez, Martin J. BlaserList of authors in order
- Landing page
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https://doi.org/10.1186/s13073-020-00764-zPublisher landing page
- PDF URL
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https://genomemedicine.biomedcentral.com/track/pdf/10.1186/s13073-020-00764-zDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://genomemedicine.biomedcentral.com/track/pdf/10.1186/s13073-020-00764-zDirect OA link when available
- Concepts
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Antibiotics, Medicine, Colitis, Course (navigation), Computational biology, Biology, Internal medicine, Microbiology, Engineering, Aerospace engineeringTop concepts (fields/topics) attached by OpenAlex
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45Total citation count in OpenAlex
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2025: 8, 2024: 5, 2023: 10, 2022: 12, 2021: 10Per-year citation counts (last 5 years)
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78Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Results | 126 |
| abstract_inverted_index.colitis | 135, 177, 200 |
| abstract_inverted_index.control | 114, 156 |
| abstract_inverted_index.crucial | 12 |
| abstract_inverted_index.dextran | 69 |
| abstract_inverted_index.disease | 38, 60, 79 |
| abstract_inverted_index.effects | 98 |
| abstract_inverted_index.mucosal | 144 |
| abstract_inverted_index.provide | 50, 190 |
| abstract_inverted_index.studies | 49 |
| abstract_inverted_index.sulfate | 71 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.altering | 143 |
| abstract_inverted_index.changing | 41 |
| abstract_inverted_index.colitis, | 73 |
| abstract_inverted_index.diseases | 25 |
| abstract_inverted_index.evidence | 5, 51, 191 |
| abstract_inverted_index.findings | 185 |
| abstract_inverted_index.increase | 197 |
| abstract_inverted_index.obtained | 158 |
| abstract_inverted_index.outcomes | 80 |
| abstract_inverted_index.severity | 178 |
| abstract_inverted_index.tylosin, | 88 |
| abstract_inverted_index.challenge | 163 |
| abstract_inverted_index.community | 141 |
| abstract_inverted_index.evaluated | 75, 96 |
| abstract_inverted_index.exposures | 55 |
| abstract_inverted_index.germ-free | 150 |
| abstract_inverted_index.macrolide | 90 |
| abstract_inverted_index.microbial | 140 |
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| abstract_inverted_index.antibiotic | 30, 54, 84 |
| abstract_inverted_index.challenged | 123 |
| abstract_inverted_index.childhood. | 27 |
| abstract_inverted_index.conditions | 39 |
| abstract_inverted_index.cytometry. | 111 |
| abstract_inverted_index.early-life | 53, 82, 193 |
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| abstract_inverted_index.subsequent | 37 |
| abstract_inverted_index.Conclusions | 183 |
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| abstract_inverted_index.exacerbated | 132 |
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| abstract_inverted_index.progression | 35 |
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| abstract_inverted_index.amoxicillin, | 92 |
| abstract_inverted_index.beta-lactam. | 94 |
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| abstract_inverted_index.perturbation | 195 |
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| abstract_inverted_index.transferrable | 168 |
| abstract_inverted_index.still-perturbed | 174 |
| abstract_inverted_index.conventionalizing | 149 |
| abstract_inverted_index.Antibiotic-perturbed | 112 |
| abstract_inverted_index.antibiotic-perturbed | 154 |
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| cited_by_percentile_year.min | 98 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 8 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8299999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
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| citation_normalized_percentile.is_in_top_10_percent | True |