A single microRNA-Hox gene module controls complex movement in morphologically-distinct developmental forms ofDrosophila Article Swipe
AR. Issa
,
João Picão-Osório
,
Nuno Rito
,
M Eugenia Chiappe
,
Claudio R. Alonso
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1101/511881
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1101/511881
Movement is the main output of the nervous system. It emerges during development to become a highly coordinated physiological process essential to the survival and adaptation of the organism to the environment. Similar movements can be observed in morphologically-distinct developmental stages of an organism, but it is currently unclear whether these movements have a common or diverse molecular basis. Here we explore this problem in Drosophila focusing on the roles played by the microRNA (miRNA) locus miR-iab4/8 which was previously shown to be essential for the fruit fly larva to correct its orientation if turned upside down (self-righting) (Picao-Osorio et al., 2015). Our study shows that miR-iab4 is required for normal self-righting across all three Drosophila larval stages. Unexpectedly, we also discover that this miRNA is essential for normal self-righting behaviour in the Drosophila adult, an organism with radically different morphological and neural constitution. Through the combination of gene-expression, optical imaging and quantitative behavioural approaches we provide evidence that miR-iab4 exerts its effects on adult self-righting behaviour through repression of the Hox gene Ultrabithorax (Ubx) (Morgan, 1923; Sánchez-Herrero et al., 1985) in a specific set of motor neurons that innervate the adult Drosophila leg. Our results show that this miRNA-Hox module affects the function, rather than the morphology of motor neurons and indicate that post-developmental changes in Hox gene expression can modulate behavioural outputs in the adult. Altogether our work reveals that a common miRNA-Hox genetic module can control complex movement in morphologically-distinct organisms and describes a novel post-developmental role of the Hox genes in adult neural function.
Related Topics
Concepts
Hox gene
Biology
Ultrabithorax
Drosophila (subgenus)
Genetics
microRNA
Gene
Cell biology
Evolutionary biology
Gene expression
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/511881
- https://www.biorxiv.org/content/biorxiv/early/2019/01/14/511881.1.full.pdf
- OA Status
- green
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2910464686
All OpenAlex metadata
Raw OpenAlex JSON
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https://doi.org/10.1101/511881Digital Object Identifier
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A single microRNA-Hox gene module controls complex movement in morphologically-distinct developmental forms ofDrosophilaWork title
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
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2019-01-14Full publication date if available
- Authors
-
AR. Issa, João Picão-Osório, Nuno Rito, M Eugenia Chiappe, Claudio R. AlonsoList of authors in order
- Landing page
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https://doi.org/10.1101/511881Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2019/01/14/511881.1.full.pdfDirect link to full text PDF
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2019/01/14/511881.1.full.pdfDirect OA link when available
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Hox gene, Biology, Ultrabithorax, Drosophila (subgenus), Genetics, microRNA, Gene, Cell biology, Evolutionary biology, Gene expressionTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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| abstract_inverted_index.to | 14, 22, 30, 82, 90 |
| abstract_inverted_index.we | 61, 120, 156 |
| abstract_inverted_index.Hox | 172, 218, 253 |
| abstract_inverted_index.Our | 103, 195 |
| abstract_inverted_index.all | 114 |
| abstract_inverted_index.and | 25, 142, 152, 212, 245 |
| abstract_inverted_index.but | 45 |
| abstract_inverted_index.can | 35, 221, 238 |
| abstract_inverted_index.fly | 88 |
| abstract_inverted_index.for | 85, 110, 128 |
| abstract_inverted_index.its | 92, 162 |
| abstract_inverted_index.our | 229 |
| abstract_inverted_index.set | 185 |
| abstract_inverted_index.the | 3, 7, 23, 28, 31, 69, 73, 86, 133, 146, 171, 191, 203, 207, 226, 252 |
| abstract_inverted_index.was | 79 |
| abstract_inverted_index.Here | 60 |
| abstract_inverted_index.al., | 101, 180 |
| abstract_inverted_index.also | 121 |
| abstract_inverted_index.down | 97 |
| abstract_inverted_index.gene | 173, 219 |
| abstract_inverted_index.have | 53 |
| abstract_inverted_index.leg. | 194 |
| abstract_inverted_index.main | 4 |
| abstract_inverted_index.role | 250 |
| abstract_inverted_index.show | 197 |
| abstract_inverted_index.than | 206 |
| abstract_inverted_index.that | 106, 123, 159, 189, 198, 214, 232 |
| abstract_inverted_index.this | 63, 124, 199 |
| abstract_inverted_index.with | 138 |
| abstract_inverted_index.work | 230 |
| abstract_inverted_index.(Ubx) | 175 |
| abstract_inverted_index.1923; | 177 |
| abstract_inverted_index.1985) | 181 |
| abstract_inverted_index.adult | 165, 192, 256 |
| abstract_inverted_index.fruit | 87 |
| abstract_inverted_index.genes | 254 |
| abstract_inverted_index.larva | 89 |
| abstract_inverted_index.locus | 76 |
| abstract_inverted_index.miRNA | 125 |
| abstract_inverted_index.motor | 187, 210 |
| abstract_inverted_index.novel | 248 |
| abstract_inverted_index.roles | 70 |
| abstract_inverted_index.shown | 81 |
| abstract_inverted_index.shows | 105 |
| abstract_inverted_index.study | 104 |
| abstract_inverted_index.these | 51 |
| abstract_inverted_index.three | 115 |
| abstract_inverted_index.which | 78 |
| abstract_inverted_index.2015). | 102 |
| abstract_inverted_index.across | 113 |
| abstract_inverted_index.adult, | 135 |
| abstract_inverted_index.adult. | 227 |
| abstract_inverted_index.basis. | 59 |
| abstract_inverted_index.become | 15 |
| abstract_inverted_index.common | 55, 234 |
| abstract_inverted_index.during | 12 |
| abstract_inverted_index.exerts | 161 |
| abstract_inverted_index.highly | 17 |
| abstract_inverted_index.larval | 117 |
| abstract_inverted_index.module | 201, 237 |
| abstract_inverted_index.neural | 143, 257 |
| abstract_inverted_index.normal | 111, 129 |
| abstract_inverted_index.output | 5 |
| abstract_inverted_index.played | 71 |
| abstract_inverted_index.rather | 205 |
| abstract_inverted_index.stages | 41 |
| abstract_inverted_index.turned | 95 |
| abstract_inverted_index.upside | 96 |
| abstract_inverted_index.(miRNA) | 75 |
| abstract_inverted_index.Similar | 33 |
| abstract_inverted_index.Through | 145 |
| abstract_inverted_index.affects | 202 |
| abstract_inverted_index.changes | 216 |
| abstract_inverted_index.complex | 240 |
| abstract_inverted_index.control | 239 |
| abstract_inverted_index.correct | 91 |
| abstract_inverted_index.diverse | 57 |
| abstract_inverted_index.effects | 163 |
| abstract_inverted_index.emerges | 11 |
| abstract_inverted_index.explore | 62 |
| abstract_inverted_index.genetic | 236 |
| abstract_inverted_index.imaging | 151 |
| abstract_inverted_index.nervous | 8 |
| abstract_inverted_index.neurons | 188, 211 |
| abstract_inverted_index.optical | 150 |
| abstract_inverted_index.outputs | 224 |
| abstract_inverted_index.problem | 64 |
| abstract_inverted_index.process | 20 |
| abstract_inverted_index.provide | 157 |
| abstract_inverted_index.results | 196 |
| abstract_inverted_index.reveals | 231 |
| abstract_inverted_index.stages. | 118 |
| abstract_inverted_index.system. | 9 |
| abstract_inverted_index.through | 168 |
| abstract_inverted_index.unclear | 49 |
| abstract_inverted_index.whether | 50 |
| abstract_inverted_index.(Morgan, | 176 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.Movement | 1 |
| abstract_inverted_index.discover | 122 |
| abstract_inverted_index.evidence | 158 |
| abstract_inverted_index.focusing | 67 |
| abstract_inverted_index.indicate | 213 |
| abstract_inverted_index.miR-iab4 | 107, 160 |
| abstract_inverted_index.microRNA | 74 |
| abstract_inverted_index.modulate | 222 |
| abstract_inverted_index.movement | 241 |
| abstract_inverted_index.observed | 37 |
| abstract_inverted_index.organism | 29, 137 |
| abstract_inverted_index.required | 109 |
| abstract_inverted_index.specific | 184 |
| abstract_inverted_index.survival | 24 |
| abstract_inverted_index.behaviour | 131, 167 |
| abstract_inverted_index.currently | 48 |
| abstract_inverted_index.describes | 246 |
| abstract_inverted_index.different | 140 |
| abstract_inverted_index.essential | 21, 84, 127 |
| abstract_inverted_index.function, | 204 |
| abstract_inverted_index.function. | 258 |
| abstract_inverted_index.innervate | 190 |
| abstract_inverted_index.miRNA-Hox | 200, 235 |
| abstract_inverted_index.molecular | 58 |
| abstract_inverted_index.movements | 34, 52 |
| abstract_inverted_index.organism, | 44 |
| abstract_inverted_index.organisms | 244 |
| abstract_inverted_index.radically | 139 |
| abstract_inverted_index.Altogether | 228 |
| abstract_inverted_index.Drosophila | 66, 116, 134, 193 |
| abstract_inverted_index.adaptation | 26 |
| abstract_inverted_index.approaches | 155 |
| abstract_inverted_index.expression | 220 |
| abstract_inverted_index.miR-iab4/8 | 77 |
| abstract_inverted_index.morphology | 208 |
| abstract_inverted_index.previously | 80 |
| abstract_inverted_index.repression | 169 |
| abstract_inverted_index.behavioural | 154, 223 |
| abstract_inverted_index.combination | 147 |
| abstract_inverted_index.coordinated | 18 |
| abstract_inverted_index.development | 13 |
| abstract_inverted_index.orientation | 93 |
| abstract_inverted_index.environment. | 32 |
| abstract_inverted_index.quantitative | 153 |
| abstract_inverted_index.(Picao-Osorio | 99 |
| abstract_inverted_index.Ultrabithorax | 174 |
| abstract_inverted_index.Unexpectedly, | 119 |
| abstract_inverted_index.constitution. | 144 |
| abstract_inverted_index.developmental | 40 |
| abstract_inverted_index.morphological | 141 |
| abstract_inverted_index.physiological | 19 |
| abstract_inverted_index.self-righting | 112, 130, 166 |
| abstract_inverted_index.(self-righting) | 98 |
| abstract_inverted_index.Sánchez-Herrero | 178 |
| abstract_inverted_index.gene-expression, | 149 |
| abstract_inverted_index.post-developmental | 215, 249 |
| abstract_inverted_index.morphologically-distinct | 39, 243 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5049021139 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 5 |
| corresponding_institution_ids | https://openalex.org/I162608824 |
| citation_normalized_percentile.value | 0.00633353 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |