A Spectral De-mixing Model for Triplex In Vivo Imaging of Optical Coherence Tomography Contrast Agents Article Swipe
Edwin Yuan
,
Peng Si
,
Saba Shevidi
,
Adam de la Zerda
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1101/846170
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1101/846170
The ability to detect multiple contrast agents simultaneously would greatly enhance Optical Coherence Tomography (OCT) images, providing nuanced biological context to physiological structures. However, previous OCT contrast agent work has been limited to scenarios where only a single contrast agent could be robustly detected within each voxel. We present a novel spectroscopic technique for de-mixing the spectral signal from multiple OCT contrast agents within a single voxel. We validate our technique in vitro and also demonstrate in vivo imaging of three spectrally distinct gold nanobipyramids, trafficking within the lymphatic system of a live mouse. This approach opens the door to a much broader range of pre-clinical and clinical OCT applications where multiplexed labeling is desirable.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/846170
- https://www.biorxiv.org/content/biorxiv/early/2019/11/18/846170.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 27
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2984715812
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2984715812Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/846170Digital Object Identifier
- Title
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A Spectral De-mixing Model for Triplex In Vivo Imaging of Optical Coherence Tomography Contrast AgentsWork title
- Type
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preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2019Year of publication
- Publication date
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2019-11-18Full publication date if available
- Authors
-
Edwin Yuan, Peng Si, Saba Shevidi, Adam de la ZerdaList of authors in order
- Landing page
-
https://doi.org/10.1101/846170Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2019/11/18/846170.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2019/11/18/846170.full.pdfDirect OA link when available
- Concepts
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Optical coherence tomography, Contrast (vision), Voxel, In vivo, Context (archaeology), Coherence (philosophical gambling strategy), Computer science, Preclinical imaging, Optics, Biomedical engineering, Artificial intelligence, Physics, Medicine, Biology, Biotechnology, Quantum mechanics, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
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2020: 1Per-year citation counts (last 5 years)
- References (count)
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27Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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