A Sphingolipidomic Profiling Approach for Comparing X-ray-Exposed and Unexposed HepG2 Cells Article Swipe
Martina Moggio
,
Bahar Faramarzi
,
Marianna Portaccio
,
Lorenzo Manti
,
Maria Lepore
,
Nadia Diano
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms241512364
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms241512364
An analytical method based on tandem mass spectrometry-shotgun is presently proposed to obtain sphingolipidomic profiles useful for the characterization of lipid extract from X-ray-exposed and unexposed hepatocellular carcinoma cells (HepG2). To obtain a targeted lipidic profile from a specific biological system, the best extraction method must be identified before instrumental analysis. Accordingly, four different classic lipid extraction protocols were compared in terms of efficiency, specificity, and reproducibility. The performance of each procedure was evaluated using the Fourier-transform infrared spectroscopic technique; subsequently, the quality of extracts was estimated using electrospray ionization tandem mass spectrometry. The selected procedure based on chloroform/methanol/water was successfully used in mass spectrometry-based shotgun sphingolipidomics, allowing for evaluation of the response of cells to X-ray irradiation, the most common anticancer therapy. Using a relative quantitative approach, the changes in the sphingolipid profiles of irradiated cell extracts were demonstrated, confirming that lipidomic technologies are also useful tools for studying the key sphingolipid role in regulating cancer growth during radiotherapy.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms241512364
- https://www.mdpi.com/1422-0067/24/15/12364/pdf?version=1690978593
- OA Status
- gold
- Cited By
- 3
- References
- 69
- Related Works
- 10
- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W4385497707Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms241512364Digital Object Identifier
- Title
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A Sphingolipidomic Profiling Approach for Comparing X-ray-Exposed and Unexposed HepG2 CellsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-08-02Full publication date if available
- Authors
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Martina Moggio, Bahar Faramarzi, Marianna Portaccio, Lorenzo Manti, Maria Lepore, Nadia DianoList of authors in order
- Landing page
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https://doi.org/10.3390/ijms241512364Publisher landing page
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https://www.mdpi.com/1422-0067/24/15/12364/pdf?version=1690978593Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1422-0067/24/15/12364/pdf?version=1690978593Direct OA link when available
- Concepts
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Tandem mass spectrometry, Electrospray ionization, Mass spectrometry, Shotgun, Chromatography, Chemistry, Sphingolipid, Biochemistry, GeneTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2024: 3Per-year citation counts (last 5 years)
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69Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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