A Study of the Effects of Oleuropein and Polydatin Association on Muscle and Bone Metabolism Article Swipe
Maria Beatrice Morelli
,
Cristina Aguzzi
,
Riccardo Rascioni
,
Fiorenzo Mignini
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/biom15050628
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/biom15050628
Sarcopenia and osteoporosis are age-related musculoskeletal pathologies that often develop in parallel, and numerous studies support the concept of a bone–muscle unit, where deep interaction between the two tissues takes place. In Mediterranean areas, the lowest incidence of osteoporosis within Europe is observed, so the Mediterranean diet was suggested to play an important role. Consequently, in this study, oleuropein, a phenolic compound found in olive oil, and polydatin, another natural polyphenol found in the Mediterranean diet, were evaluated to determine their beneficial effects on bone and muscle metabolism. In human osteoblasts and skeletal muscle myoblasts, the effects were examined, and, after analyzing the cytotoxic effect to find non-toxic doses, the modulation of bone and muscle differentiation markers was evaluated at the gene and protein levels using PCR, Western blot, and immunohistochemistry. Interestingly, the compounds increased markers involved in osteoblast differentiation, such as osteocalcin, type I collagen, and dentin-sialo-phosphoprotein, as well as markers involved in myoblast differentiation, such as myogenic regulatory factors and creatine kinase. These effects were most noticeable when the compounds were administered together. These results suggest a beneficial role for oleuropein–polydatin association on bone and muscle tissue pathologies simultaneously.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/biom15050628
- https://www.mdpi.com/2218-273X/15/5/628/pdf?version=1745829080
- OA Status
- gold
- Cited By
- 3
- References
- 69
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410033250
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4410033250Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/biom15050628Digital Object Identifier
- Title
-
A Study of the Effects of Oleuropein and Polydatin Association on Muscle and Bone MetabolismWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-04-28Full publication date if available
- Authors
-
Maria Beatrice Morelli, Cristina Aguzzi, Riccardo Rascioni, Fiorenzo MigniniList of authors in order
- Landing page
-
https://doi.org/10.3390/biom15050628Publisher landing page
- PDF URL
-
https://www.mdpi.com/2218-273X/15/5/628/pdf?version=1745829080Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2218-273X/15/5/628/pdf?version=1745829080Direct OA link when available
- Concepts
-
Oleuropein, Endocrinology, Bone remodeling, Osteoblast, Internal medicine, Chemistry, Osteocalcin, Myocyte, Skeletal muscle, Osteocyte, Western blot, Muscle tissue, Osteoporosis, Biochemistry, Medicine, Alkaline phosphatase, Antioxidant, Enzyme, Gene, In vitroTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3Per-year citation counts (last 5 years)
- References (count)
-
69Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| sustainable_development_goals[0].display_name | Life below water |
| citation_normalized_percentile.value | 0.9554411 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |