A Systematic Review of the Biological Processes Involved in Deep-Brain Stimulation for Parkinson's disease: A Focus on the Potential Disease-Modifying Effects Article Swipe
Francesco Sciancalepore
,
Giulia Remoli
,
Leonardo Tariciotti
,
Giulia Sarti
,
Federica Trentin
,
Gabriele Riccardi
,
Eleonora Lacorte
,
Massimo Corbo
,
Marco Canevelli
,
Nicola Vanacore
,
Paola Piscopo
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21926/obm.neurobiol.2102097
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21926/obm.neurobiol.2102097
Deep-Brain Stimulation (DBS) is an important treatment option for the management of Parkinson’s disease (PD) and is a common symptomatic treatment. However, an increasing number of studies have examined the biological processes to assess if DBS can also modify the natural history of PD by acting on its pathophysiological mechanisms. Relevant literature published up to November 2020 was systematically searched on databases such as PubMed, ISI Web of Knowledge, Academic Search Index, and Science Citation Index. The following predefined inclusion criteria were applied to the full-text versions of the selected articles: i) recruiting and monitoring of PD subjects that were previously treated with DBS and ii) investigating the electrophysiological, biochemical, epigenetic, or neuroimaging effects of DBS. Studies focusing exclusively on motor and clinical changes were excluded. Reviews, case reports, studies on animal models, and computational studies were also not considered. Out of 2,960 records screened, 43 studies met the inclusion criteria. Only three studies described a potential disease-modifying effect of DBS. However, a wide heterogeneity was observed in the investigated biomarkers, and the design and methodological issues of several studies limited their ability to find potential disease-modifying features. Specifically, 60.4% of the trials followed-up subjects for no more than 1 year from the surgical intervention, and 67.4% observed patients with PD only once after DBS. Moreover, 64.2% of the studies enrolled late-stage PD patients. Most of the studies (88.4%) reported that DBS only had a symptomatic effect, with several of them showing some limitations in the study design and recruitment of patients. Further studies using shared biomarkers are encouraged to assess if and how DBS might affect the progression of PD. Based on the existing preclinical literature, prospective clinical trials examining the course of PD in early-stage patients are needed.
Related Topics
Concepts
Deep brain stimulation
Disease
Parkinson's disease
Medicine
Neuroimaging
Movement disorders
Natural history
Motor symptoms
Clinical trial
Neuropsychology
Psychology
Neuroscience
Bioinformatics
Cognition
Pathology
Internal medicine
Biology
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.21926/obm.neurobiol.2102097
- https://www.lidsen.com/journals/neurobiology/neurobiology-05-02-097/obm.neurobiol.2102097.pdf
- OA Status
- diamond
- References
- 86
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3163336574
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3163336574Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21926/obm.neurobiol.2102097Digital Object Identifier
- Title
-
A Systematic Review of the Biological Processes Involved in Deep-Brain Stimulation for Parkinson's disease: A Focus on the Potential Disease-Modifying EffectsWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-05-19Full publication date if available
- Authors
-
Francesco Sciancalepore, Giulia Remoli, Leonardo Tariciotti, Giulia Sarti, Federica Trentin, Gabriele Riccardi, Eleonora Lacorte, Massimo Corbo, Marco Canevelli, Nicola Vanacore, Paola PiscopoList of authors in order
- Landing page
-
https://doi.org/10.21926/obm.neurobiol.2102097Publisher landing page
- PDF URL
-
https://www.lidsen.com/journals/neurobiology/neurobiology-05-02-097/obm.neurobiol.2102097.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.lidsen.com/journals/neurobiology/neurobiology-05-02-097/obm.neurobiol.2102097.pdfDirect OA link when available
- Concepts
-
Deep brain stimulation, Disease, Parkinson's disease, Medicine, Neuroimaging, Movement disorders, Natural history, Motor symptoms, Clinical trial, Neuropsychology, Psychology, Neuroscience, Bioinformatics, Cognition, Pathology, Internal medicine, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
86Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3163336574 |
|---|---|
| doi | https://doi.org/10.21926/obm.neurobiol.2102097 |
| ids.doi | https://doi.org/10.21926/obm.neurobiol.2102097 |
| ids.mag | 3163336574 |
| ids.openalex | https://openalex.org/W3163336574 |
| fwci | 0.0 |
| type | review |
| title | A Systematic Review of the Biological Processes Involved in Deep-Brain Stimulation for Parkinson's disease: A Focus on the Potential Disease-Modifying Effects |
| biblio.issue | 02 |
| biblio.volume | 05 |
| biblio.last_page | 23 |
| biblio.first_page | 1 |
| topics[0].id | https://openalex.org/T10919 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2728 |
| topics[0].subfield.display_name | Neurology |
| topics[0].display_name | Neurological disorders and treatments |
| topics[1].id | https://openalex.org/T10085 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9997000098228455 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2728 |
| topics[1].subfield.display_name | Neurology |
| topics[1].display_name | Parkinson's Disease Mechanisms and Treatments |
| topics[2].id | https://openalex.org/T11601 |
| topics[2].field.id | https://openalex.org/fields/28 |
| topics[2].field.display_name | Neuroscience |
| topics[2].score | 0.995199978351593 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2804 |
| topics[2].subfield.display_name | Cellular and Molecular Neuroscience |
| topics[2].display_name | Neuroscience and Neural Engineering |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2778542668 |
| concepts[0].level | 4 |
| concepts[0].score | 0.8722946643829346 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q618076 |
| concepts[0].display_name | Deep brain stimulation |
| concepts[1].id | https://openalex.org/C2779134260 |
| concepts[1].level | 2 |
| concepts[1].score | 0.6632354259490967 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[1].display_name | Disease |
| concepts[2].id | https://openalex.org/C2779734285 |
| concepts[2].level | 3 |
| concepts[2].score | 0.643131673336029 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q11085 |
| concepts[2].display_name | Parkinson's disease |
| concepts[3].id | https://openalex.org/C71924100 |
| concepts[3].level | 0 |
| concepts[3].score | 0.5039626955986023 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[3].display_name | Medicine |
| concepts[4].id | https://openalex.org/C58693492 |
| concepts[4].level | 2 |
| concepts[4].score | 0.4485640525817871 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q551875 |
| concepts[4].display_name | Neuroimaging |
| concepts[5].id | https://openalex.org/C2778261627 |
| concepts[5].level | 3 |
| concepts[5].score | 0.4449978768825531 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q2608695 |
| concepts[5].display_name | Movement disorders |
| concepts[6].id | https://openalex.org/C163276114 |
| concepts[6].level | 2 |
| concepts[6].score | 0.427146315574646 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q484591 |
| concepts[6].display_name | Natural history |
| concepts[7].id | https://openalex.org/C3018987647 |
| concepts[7].level | 4 |
| concepts[7].score | 0.42541825771331787 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q3221083 |
| concepts[7].display_name | Motor symptoms |
| concepts[8].id | https://openalex.org/C535046627 |
| concepts[8].level | 2 |
| concepts[8].score | 0.4200073182582855 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q30612 |
| concepts[8].display_name | Clinical trial |
| concepts[9].id | https://openalex.org/C14216870 |
| concepts[9].level | 3 |
| concepts[9].score | 0.4184938371181488 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q3872 |
| concepts[9].display_name | Neuropsychology |
| concepts[10].id | https://openalex.org/C15744967 |
| concepts[10].level | 0 |
| concepts[10].score | 0.3986295461654663 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q9418 |
| concepts[10].display_name | Psychology |
| concepts[11].id | https://openalex.org/C169760540 |
| concepts[11].level | 1 |
| concepts[11].score | 0.3695037066936493 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[11].display_name | Neuroscience |
| concepts[12].id | https://openalex.org/C60644358 |
| concepts[12].level | 1 |
| concepts[12].score | 0.33697807788848877 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q128570 |
| concepts[12].display_name | Bioinformatics |
| concepts[13].id | https://openalex.org/C169900460 |
| concepts[13].level | 2 |
| concepts[13].score | 0.27143043279647827 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q2200417 |
| concepts[13].display_name | Cognition |
| concepts[14].id | https://openalex.org/C142724271 |
| concepts[14].level | 1 |
| concepts[14].score | 0.20842990279197693 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[14].display_name | Pathology |
| concepts[15].id | https://openalex.org/C126322002 |
| concepts[15].level | 1 |
| concepts[15].score | 0.19253137707710266 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[15].display_name | Internal medicine |
| concepts[16].id | https://openalex.org/C86803240 |
| concepts[16].level | 0 |
| concepts[16].score | 0.08599042892456055 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[16].display_name | Biology |
| keywords[0].id | https://openalex.org/keywords/deep-brain-stimulation |
| keywords[0].score | 0.8722946643829346 |
| keywords[0].display_name | Deep brain stimulation |
| keywords[1].id | https://openalex.org/keywords/disease |
| keywords[1].score | 0.6632354259490967 |
| keywords[1].display_name | Disease |
| keywords[2].id | https://openalex.org/keywords/parkinsons-disease |
| keywords[2].score | 0.643131673336029 |
| keywords[2].display_name | Parkinson's disease |
| keywords[3].id | https://openalex.org/keywords/medicine |
| keywords[3].score | 0.5039626955986023 |
| keywords[3].display_name | Medicine |
| keywords[4].id | https://openalex.org/keywords/neuroimaging |
| keywords[4].score | 0.4485640525817871 |
| keywords[4].display_name | Neuroimaging |
| keywords[5].id | https://openalex.org/keywords/movement-disorders |
| keywords[5].score | 0.4449978768825531 |
| keywords[5].display_name | Movement disorders |
| keywords[6].id | https://openalex.org/keywords/natural-history |
| keywords[6].score | 0.427146315574646 |
| keywords[6].display_name | Natural history |
| keywords[7].id | https://openalex.org/keywords/motor-symptoms |
| keywords[7].score | 0.42541825771331787 |
| keywords[7].display_name | Motor symptoms |
| keywords[8].id | https://openalex.org/keywords/clinical-trial |
| keywords[8].score | 0.4200073182582855 |
| keywords[8].display_name | Clinical trial |
| keywords[9].id | https://openalex.org/keywords/neuropsychology |
| keywords[9].score | 0.4184938371181488 |
| keywords[9].display_name | Neuropsychology |
| keywords[10].id | https://openalex.org/keywords/psychology |
| keywords[10].score | 0.3986295461654663 |
| keywords[10].display_name | Psychology |
| keywords[11].id | https://openalex.org/keywords/neuroscience |
| keywords[11].score | 0.3695037066936493 |
| keywords[11].display_name | Neuroscience |
| keywords[12].id | https://openalex.org/keywords/bioinformatics |
| keywords[12].score | 0.33697807788848877 |
| keywords[12].display_name | Bioinformatics |
| keywords[13].id | https://openalex.org/keywords/cognition |
| keywords[13].score | 0.27143043279647827 |
| keywords[13].display_name | Cognition |
| keywords[14].id | https://openalex.org/keywords/pathology |
| keywords[14].score | 0.20842990279197693 |
| keywords[14].display_name | Pathology |
| keywords[15].id | https://openalex.org/keywords/internal-medicine |
| keywords[15].score | 0.19253137707710266 |
| keywords[15].display_name | Internal medicine |
| keywords[16].id | https://openalex.org/keywords/biology |
| keywords[16].score | 0.08599042892456055 |
| keywords[16].display_name | Biology |
| language | en |
| locations[0].id | doi:10.21926/obm.neurobiol.2102097 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210221663 |
| locations[0].source.issn | 2573-4407 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2573-4407 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | OBM Neurobiology |
| locations[0].source.host_organization | |
| locations[0].source.host_organization_name | |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.lidsen.com/journals/neurobiology/neurobiology-05-02-097/obm.neurobiol.2102097.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | OBM Neurobiology |
| locations[0].landing_page_url | https://doi.org/10.21926/obm.neurobiol.2102097 |
| locations[1].id | pmh:oai:iris.uniroma1.it:11573/1690847 |
| locations[1].is_oa | True |
| locations[1].source.id | https://openalex.org/S4377196107 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | IRIS Research product catalog (Sapienza University of Rome) |
| locations[1].source.host_organization | |
| locations[1].source.host_organization_name | |
| locations[1].license | other-oa |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | info:eu-repo/semantics/article |
| locations[1].license_id | https://openalex.org/licenses/other-oa |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | |
| locations[1].landing_page_url | https://hdl.handle.net/11573/1690847 |
| locations[2].id | pmh:oai:zenodo.org:150126 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400562 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | True |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Zenodo (CERN European Organization for Nuclear Research) |
| locations[2].source.host_organization | https://openalex.org/I67311998 |
| locations[2].source.host_organization_name | European Organization for Nuclear Research |
| locations[2].source.host_organization_lineage | https://openalex.org/I67311998 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | publishedVersion |
| locations[2].raw_type | info:eu-repo/semantics/article |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | True |
| locations[2].is_published | True |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://www.openaccessrepository.it/record/150126 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5086467439 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-1241-074X |
| authorships[0].author.display_name | Francesco Sciancalepore |
| authorships[0].countries | IT |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I27897274, https://openalex.org/I4210095408 |
| authorships[0].affiliations[0].raw_affiliation_string | . National Center for Disease Prevention and Health Promotion, Italian National Institute of Health, Viale Regina Elena, 299, 00161 Rome, Italy; |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I861853513 |
| authorships[0].affiliations[1].raw_affiliation_string | . Department of Human Neuroscience, "Sapienza" University of Rome, Rome, Italy; |
| authorships[0].institutions[0].id | https://openalex.org/I27897274 |
| authorships[0].institutions[0].ror | https://ror.org/02hssy432 |
| authorships[0].institutions[0].type | government |
| authorships[0].institutions[0].lineage | https://openalex.org/I27897274 |
| authorships[0].institutions[0].country_code | IT |
| authorships[0].institutions[0].display_name | Istituto Superiore di Sanità |
| authorships[0].institutions[1].id | https://openalex.org/I4210095408 |
| authorships[0].institutions[1].ror | https://ror.org/00svmjx28 |
| authorships[0].institutions[1].type | government |
| authorships[0].institutions[1].lineage | https://openalex.org/I2801313885, https://openalex.org/I4210095408, https://openalex.org/I4210104593 |
| authorships[0].institutions[1].country_code | IT |
| authorships[0].institutions[1].display_name | National Centre for Disease Prevention and Control |
| authorships[0].institutions[2].id | https://openalex.org/I861853513 |
| authorships[0].institutions[2].ror | https://ror.org/02be6w209 |
| authorships[0].institutions[2].type | education |
| authorships[0].institutions[2].lineage | https://openalex.org/I861853513 |
| authorships[0].institutions[2].country_code | IT |
| authorships[0].institutions[2].display_name | Sapienza University of Rome |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Francesco Sciancalepore |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | . Department of Human Neuroscience, "Sapienza" University of Rome, Rome, Italy;, . National Center for Disease Prevention and Health Promotion, Italian National Institute of Health, Viale Regina Elena, 299, 00161 Rome, Italy; |
| authorships[1].author.id | https://openalex.org/A5091576768 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Giulia Remoli |
| authorships[1].countries | IT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I27897274, https://openalex.org/I4210095408 |
| authorships[1].affiliations[0].raw_affiliation_string | . National Center for Disease Prevention and Health Promotion, Italian National Institute of Health, Viale Regina Elena, 299, 00161 Rome, Italy; |
| authorships[1].institutions[0].id | https://openalex.org/I27897274 |
| authorships[1].institutions[0].ror | https://ror.org/02hssy432 |
| authorships[1].institutions[0].type | government |
| authorships[1].institutions[0].lineage | https://openalex.org/I27897274 |
| authorships[1].institutions[0].country_code | IT |
| authorships[1].institutions[0].display_name | Istituto Superiore di Sanità |
| authorships[1].institutions[1].id | https://openalex.org/I4210095408 |
| authorships[1].institutions[1].ror | https://ror.org/00svmjx28 |
| authorships[1].institutions[1].type | government |
| authorships[1].institutions[1].lineage | https://openalex.org/I2801313885, https://openalex.org/I4210095408, https://openalex.org/I4210104593 |
| authorships[1].institutions[1].country_code | IT |
| authorships[1].institutions[1].display_name | National Centre for Disease Prevention and Control |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Giulia Remoli |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | . National Center for Disease Prevention and Health Promotion, Italian National Institute of Health, Viale Regina Elena, 299, 00161 Rome, Italy; |
| authorships[2].author.id | https://openalex.org/A5044251515 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-5942-6677 |
| authorships[2].author.display_name | Leonardo Tariciotti |
| authorships[2].countries | IT |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I189158943 |
| authorships[2].affiliations[0].raw_affiliation_string | . Department of Oncology and Hemato-oncology, University of Milan, Via Festa del Perdono 7, 20122 Milan, Italy |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I189158943, https://openalex.org/I2803066834 |
| authorships[2].affiliations[1].raw_affiliation_string | . Unit of Neurosurgery, IRCSS Fondazione Cà Grande Ospedale Maggiore Policlinico, University of Milan, Via Francesco Sforza, 35, 20122 Milan, Italy; |
| authorships[2].institutions[0].id | https://openalex.org/I2803066834 |
| authorships[2].institutions[0].ror | https://ror.org/016zn0y21 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I2803066834, https://openalex.org/I4210153126 |
| authorships[2].institutions[0].country_code | IT |
| authorships[2].institutions[0].display_name | Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico |
| authorships[2].institutions[1].id | https://openalex.org/I189158943 |
| authorships[2].institutions[1].ror | https://ror.org/00wjc7c48 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I189158943 |
| authorships[2].institutions[1].country_code | IT |
| authorships[2].institutions[1].display_name | University of Milan |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Leonardo Tariciotti |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | . Department of Oncology and Hemato-oncology, University of Milan, Via Festa del Perdono 7, 20122 Milan, Italy, . Unit of Neurosurgery, IRCSS Fondazione Cà Grande Ospedale Maggiore Policlinico, University of Milan, Via Francesco Sforza, 35, 20122 Milan, Italy; |
| authorships[3].author.id | https://openalex.org/A5043544093 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Giulia Sarti |
| authorships[3].countries | IT |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I861853513 |
| authorships[3].affiliations[0].raw_affiliation_string | . Department of Human Neuroscience, "Sapienza" University of Rome, Rome, Italy; |
| authorships[3].institutions[0].id | https://openalex.org/I861853513 |
| authorships[3].institutions[0].ror | https://ror.org/02be6w209 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I861853513 |
| authorships[3].institutions[0].country_code | IT |
| authorships[3].institutions[0].display_name | Sapienza University of Rome |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Giulia Sarti |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | . Department of Human Neuroscience, "Sapienza" University of Rome, Rome, Italy; |
| authorships[4].author.id | https://openalex.org/A5045309395 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Federica Trentin |
| authorships[4].countries | IT |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210121742 |
| authorships[4].affiliations[0].raw_affiliation_string | . Department of Oncological and Degenerative Spine Surgery, IRCCS, Rizzoli Orthopedic Institute, Via G.C. Pupilli, 1, 40136 Bologna, Italy; |
| authorships[4].institutions[0].id | https://openalex.org/I4210121742 |
| authorships[4].institutions[0].ror | https://ror.org/02ycyys66 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210121742, https://openalex.org/I4210153126 |
| authorships[4].institutions[0].country_code | IT |
| authorships[4].institutions[0].display_name | Istituto Ortopedico Rizzoli |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Federica Trentin |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | . Department of Oncological and Degenerative Spine Surgery, IRCCS, Rizzoli Orthopedic Institute, Via G.C. Pupilli, 1, 40136 Bologna, Italy; |
| authorships[5].author.id | https://openalex.org/A5053496447 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-2696-1048 |
| authorships[5].author.display_name | Gabriele Riccardi |
| authorships[5].countries | IT |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I2800330116, https://openalex.org/I861853513 |
| authorships[5].affiliations[0].raw_affiliation_string | . Department of Sense Organ, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy; |
| authorships[5].institutions[0].id | https://openalex.org/I2800330116 |
| authorships[5].institutions[0].ror | https://ror.org/011cabk38 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I2800330116 |
| authorships[5].institutions[0].country_code | IT |
| authorships[5].institutions[0].display_name | Policlinico Umberto I |
| authorships[5].institutions[1].id | https://openalex.org/I861853513 |
| authorships[5].institutions[1].ror | https://ror.org/02be6w209 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I861853513 |
| authorships[5].institutions[1].country_code | IT |
| authorships[5].institutions[1].display_name | Sapienza University of Rome |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Gabriele Riccardi |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | . Department of Sense Organ, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy; |
| authorships[6].author.id | https://openalex.org/A5041336591 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-8530-9207 |
| authorships[6].author.display_name | Eleonora Lacorte |
| authorships[6].countries | IT |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I27897274, https://openalex.org/I4210095408 |
| authorships[6].affiliations[0].raw_affiliation_string | . National Center for Disease Prevention and Health Promotion, Italian National Institute of Health, Viale Regina Elena, 299, 00161 Rome, Italy; |
| authorships[6].institutions[0].id | https://openalex.org/I27897274 |
| authorships[6].institutions[0].ror | https://ror.org/02hssy432 |
| authorships[6].institutions[0].type | government |
| authorships[6].institutions[0].lineage | https://openalex.org/I27897274 |
| authorships[6].institutions[0].country_code | IT |
| authorships[6].institutions[0].display_name | Istituto Superiore di Sanità |
| authorships[6].institutions[1].id | https://openalex.org/I4210095408 |
| authorships[6].institutions[1].ror | https://ror.org/00svmjx28 |
| authorships[6].institutions[1].type | government |
| authorships[6].institutions[1].lineage | https://openalex.org/I2801313885, https://openalex.org/I4210095408, https://openalex.org/I4210104593 |
| authorships[6].institutions[1].country_code | IT |
| authorships[6].institutions[1].display_name | National Centre for Disease Prevention and Control |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Eleonora Lacorte |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | . National Center for Disease Prevention and Health Promotion, Italian National Institute of Health, Viale Regina Elena, 299, 00161 Rome, Italy; |
| authorships[7].author.id | https://openalex.org/A5064998679 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-0793-9830 |
| authorships[7].author.display_name | Massimo Corbo |
| authorships[7].affiliations[0].raw_affiliation_string | . Department of Neurorehabilitation Sciences, Casa Cura Policlinico, Via Dezza 48, 20144 Milan, Italy; |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Massimo Corbo |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | . Department of Neurorehabilitation Sciences, Casa Cura Policlinico, Via Dezza 48, 20144 Milan, Italy; |
| authorships[8].author.id | https://openalex.org/A5021137368 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-7333-6478 |
| authorships[8].author.display_name | Marco Canevelli |
| authorships[8].countries | IT |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I27897274, https://openalex.org/I4210095408 |
| authorships[8].affiliations[0].raw_affiliation_string | . National Center for Disease Prevention and Health Promotion, Italian National Institute of Health, Viale Regina Elena, 299, 00161 Rome, Italy; |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I861853513 |
| authorships[8].affiliations[1].raw_affiliation_string | . Department of Human Neuroscience, "Sapienza" University of Rome, Rome, Italy; |
| authorships[8].institutions[0].id | https://openalex.org/I27897274 |
| authorships[8].institutions[0].ror | https://ror.org/02hssy432 |
| authorships[8].institutions[0].type | government |
| authorships[8].institutions[0].lineage | https://openalex.org/I27897274 |
| authorships[8].institutions[0].country_code | IT |
| authorships[8].institutions[0].display_name | Istituto Superiore di Sanità |
| authorships[8].institutions[1].id | https://openalex.org/I4210095408 |
| authorships[8].institutions[1].ror | https://ror.org/00svmjx28 |
| authorships[8].institutions[1].type | government |
| authorships[8].institutions[1].lineage | https://openalex.org/I2801313885, https://openalex.org/I4210095408, https://openalex.org/I4210104593 |
| authorships[8].institutions[1].country_code | IT |
| authorships[8].institutions[1].display_name | National Centre for Disease Prevention and Control |
| authorships[8].institutions[2].id | https://openalex.org/I861853513 |
| authorships[8].institutions[2].ror | https://ror.org/02be6w209 |
| authorships[8].institutions[2].type | education |
| authorships[8].institutions[2].lineage | https://openalex.org/I861853513 |
| authorships[8].institutions[2].country_code | IT |
| authorships[8].institutions[2].display_name | Sapienza University of Rome |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Marco Canevelli |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | . Department of Human Neuroscience, "Sapienza" University of Rome, Rome, Italy;, . National Center for Disease Prevention and Health Promotion, Italian National Institute of Health, Viale Regina Elena, 299, 00161 Rome, Italy; |
| authorships[9].author.id | https://openalex.org/A5034416695 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-2817-3758 |
| authorships[9].author.display_name | Nicola Vanacore |
| authorships[9].countries | IT |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I27897274, https://openalex.org/I4210095408 |
| authorships[9].affiliations[0].raw_affiliation_string | . National Center for Disease Prevention and Health Promotion, Italian National Institute of Health, Viale Regina Elena, 299, 00161 Rome, Italy; |
| authorships[9].institutions[0].id | https://openalex.org/I27897274 |
| authorships[9].institutions[0].ror | https://ror.org/02hssy432 |
| authorships[9].institutions[0].type | government |
| authorships[9].institutions[0].lineage | https://openalex.org/I27897274 |
| authorships[9].institutions[0].country_code | IT |
| authorships[9].institutions[0].display_name | Istituto Superiore di Sanità |
| authorships[9].institutions[1].id | https://openalex.org/I4210095408 |
| authorships[9].institutions[1].ror | https://ror.org/00svmjx28 |
| authorships[9].institutions[1].type | government |
| authorships[9].institutions[1].lineage | https://openalex.org/I2801313885, https://openalex.org/I4210095408, https://openalex.org/I4210104593 |
| authorships[9].institutions[1].country_code | IT |
| authorships[9].institutions[1].display_name | National Centre for Disease Prevention and Control |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Nicola Vanacore |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | . National Center for Disease Prevention and Health Promotion, Italian National Institute of Health, Viale Regina Elena, 299, 00161 Rome, Italy; |
| authorships[10].author.id | https://openalex.org/A5076337357 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-0693-4969 |
| authorships[10].author.display_name | Paola Piscopo |
| authorships[10].countries | IT |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I27897274 |
| authorships[10].affiliations[0].raw_affiliation_string | . Department of Neuroscience, Italian National Institute of Health, Viale Regina Elena, 299, 00161 Rome, Italy; |
| authorships[10].institutions[0].id | https://openalex.org/I27897274 |
| authorships[10].institutions[0].ror | https://ror.org/02hssy432 |
| authorships[10].institutions[0].type | government |
| authorships[10].institutions[0].lineage | https://openalex.org/I27897274 |
| authorships[10].institutions[0].country_code | IT |
| authorships[10].institutions[0].display_name | Istituto Superiore di Sanità |
| authorships[10].author_position | last |
| authorships[10].raw_author_name | Paola Piscopo |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | . Department of Neuroscience, Italian National Institute of Health, Viale Regina Elena, 299, 00161 Rome, Italy; |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.lidsen.com/journals/neurobiology/neurobiology-05-02-097/obm.neurobiol.2102097.pdf |
| open_access.oa_status | diamond |
| open_access.any_repository_has_fulltext | False |
| created_date | 2021-05-24T00:00:00 |
| display_name | A Systematic Review of the Biological Processes Involved in Deep-Brain Stimulation for Parkinson's disease: A Focus on the Potential Disease-Modifying Effects |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10919 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2728 |
| primary_topic.subfield.display_name | Neurology |
| primary_topic.display_name | Neurological disorders and treatments |
| related_works | https://openalex.org/W2999122545, https://openalex.org/W2063726860, https://openalex.org/W1968231764, https://openalex.org/W2409876136, https://openalex.org/W2218427460, https://openalex.org/W2041016900, https://openalex.org/W4366381095, https://openalex.org/W4402581907, https://openalex.org/W2238518289, https://openalex.org/W1137271273 |
| cited_by_count | 0 |
| locations_count | 3 |
| best_oa_location.id | doi:10.21926/obm.neurobiol.2102097 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210221663 |
| best_oa_location.source.issn | 2573-4407 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2573-4407 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | OBM Neurobiology |
| best_oa_location.source.host_organization | |
| best_oa_location.source.host_organization_name | |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.lidsen.com/journals/neurobiology/neurobiology-05-02-097/obm.neurobiol.2102097.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | OBM Neurobiology |
| best_oa_location.landing_page_url | https://doi.org/10.21926/obm.neurobiol.2102097 |
| primary_location.id | doi:10.21926/obm.neurobiol.2102097 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210221663 |
| primary_location.source.issn | 2573-4407 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2573-4407 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | OBM Neurobiology |
| primary_location.source.host_organization | |
| primary_location.source.host_organization_name | |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.lidsen.com/journals/neurobiology/neurobiology-05-02-097/obm.neurobiol.2102097.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | OBM Neurobiology |
| primary_location.landing_page_url | https://doi.org/10.21926/obm.neurobiol.2102097 |
| publication_date | 2021-05-19 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W6808519316, https://openalex.org/W2338643926, https://openalex.org/W2026371611, https://openalex.org/W2123984617, https://openalex.org/W1557380268, https://openalex.org/W2164068340, https://openalex.org/W2123208606, https://openalex.org/W179297973, https://openalex.org/W2074616189, https://openalex.org/W2157583512, https://openalex.org/W1775367891, https://openalex.org/W1947356649, https://openalex.org/W2098923148, https://openalex.org/W2012932483, https://openalex.org/W2889839969, https://openalex.org/W2969099018, https://openalex.org/W2022602971, https://openalex.org/W2559831737, https://openalex.org/W2136193649, https://openalex.org/W2094289318, https://openalex.org/W2009633584, https://openalex.org/W2008686569, https://openalex.org/W2066398961, https://openalex.org/W2063207426, https://openalex.org/W1980337627, https://openalex.org/W2026688262, https://openalex.org/W1768505473, https://openalex.org/W2017782030, https://openalex.org/W2087177425, https://openalex.org/W2093835832, https://openalex.org/W2056849177, https://openalex.org/W2802454392, https://openalex.org/W2511785087, https://openalex.org/W2141153549, https://openalex.org/W3096402170, https://openalex.org/W2971855587, https://openalex.org/W2116496076, https://openalex.org/W2128908582, https://openalex.org/W2033362643, https://openalex.org/W2607390862, https://openalex.org/W3086854276, https://openalex.org/W2119523320, https://openalex.org/W2937204925, https://openalex.org/W2024377399, https://openalex.org/W6823191125, https://openalex.org/W2112455323, https://openalex.org/W2070951127, https://openalex.org/W1967659552, https://openalex.org/W1978793506, https://openalex.org/W2131671532, https://openalex.org/W2014122802, https://openalex.org/W2106956384, https://openalex.org/W2150295951, https://openalex.org/W2891923590, https://openalex.org/W2380561257, https://openalex.org/W2972917454, https://openalex.org/W2903866269, https://openalex.org/W1988872843, https://openalex.org/W2793280473, https://openalex.org/W4293602920, https://openalex.org/W2019010892, https://openalex.org/W4296217258, https://openalex.org/W1950910266, https://openalex.org/W4399625654, https://openalex.org/W2066818645, https://openalex.org/W2029565457, https://openalex.org/W2036573649, https://openalex.org/W2913766627, https://openalex.org/W3150948471, https://openalex.org/W2741917192, https://openalex.org/W3090034910, https://openalex.org/W2991488733, https://openalex.org/W2809025812, https://openalex.org/W1977252372, https://openalex.org/W4237163241, https://openalex.org/W2075341360, https://openalex.org/W3005709677, https://openalex.org/W2096315617, https://openalex.org/W2093720978, https://openalex.org/W2158648287, https://openalex.org/W4240897894, https://openalex.org/W2340513490, https://openalex.org/W2090386235, https://openalex.org/W3111521247, https://openalex.org/W2045434558, https://openalex.org/W2995052791 |
| referenced_works_count | 86 |
| abstract_inverted_index.1 | 199 |
| abstract_inverted_index.a | 17, 155, 162, 234 |
| abstract_inverted_index.43 | 145 |
| abstract_inverted_index.PD | 43, 96, 210, 222, 284 |
| abstract_inverted_index.an | 4, 22 |
| abstract_inverted_index.as | 63 |
| abstract_inverted_index.by | 44 |
| abstract_inverted_index.i) | 91 |
| abstract_inverted_index.if | 34, 261 |
| abstract_inverted_index.in | 167, 244, 285 |
| abstract_inverted_index.is | 3, 16 |
| abstract_inverted_index.no | 196 |
| abstract_inverted_index.of | 11, 25, 42, 67, 87, 95, 114, 141, 159, 177, 190, 217, 225, 239, 250, 269, 283 |
| abstract_inverted_index.on | 46, 60, 119, 130, 272 |
| abstract_inverted_index.or | 111 |
| abstract_inverted_index.to | 32, 54, 83, 183, 259 |
| abstract_inverted_index.up | 53 |
| abstract_inverted_index.DBS | 35, 103, 231, 264 |
| abstract_inverted_index.ISI | 65 |
| abstract_inverted_index.Out | 140 |
| abstract_inverted_index.PD. | 270 |
| abstract_inverted_index.The | 76 |
| abstract_inverted_index.Web | 66 |
| abstract_inverted_index.and | 15, 72, 93, 104, 121, 133, 171, 174, 205, 248, 262 |
| abstract_inverted_index.are | 257, 288 |
| abstract_inverted_index.can | 36 |
| abstract_inverted_index.for | 8, 195 |
| abstract_inverted_index.had | 233 |
| abstract_inverted_index.how | 263 |
| abstract_inverted_index.ii) | 105 |
| abstract_inverted_index.its | 47 |
| abstract_inverted_index.met | 147 |
| abstract_inverted_index.not | 138 |
| abstract_inverted_index.the | 9, 29, 39, 84, 88, 107, 148, 168, 172, 191, 202, 218, 226, 245, 267, 273, 281 |
| abstract_inverted_index.was | 57, 165 |
| abstract_inverted_index.(PD) | 14 |
| abstract_inverted_index.2020 | 56 |
| abstract_inverted_index.DBS. | 115, 160, 214 |
| abstract_inverted_index.Most | 224 |
| abstract_inverted_index.Only | 151 |
| abstract_inverted_index.also | 37, 137 |
| abstract_inverted_index.case | 127 |
| abstract_inverted_index.find | 184 |
| abstract_inverted_index.from | 201 |
| abstract_inverted_index.have | 27 |
| abstract_inverted_index.more | 197 |
| abstract_inverted_index.once | 212 |
| abstract_inverted_index.only | 211, 232 |
| abstract_inverted_index.some | 242 |
| abstract_inverted_index.such | 62 |
| abstract_inverted_index.than | 198 |
| abstract_inverted_index.that | 98, 230 |
| abstract_inverted_index.them | 240 |
| abstract_inverted_index.were | 81, 99, 124, 136 |
| abstract_inverted_index.wide | 163 |
| abstract_inverted_index.with | 102, 209, 237 |
| abstract_inverted_index.year | 200 |
| abstract_inverted_index.(DBS) | 2 |
| abstract_inverted_index.2,960 | 142 |
| abstract_inverted_index.60.4% | 189 |
| abstract_inverted_index.64.2% | 216 |
| abstract_inverted_index.67.4% | 206 |
| abstract_inverted_index.Based | 271 |
| abstract_inverted_index.after | 213 |
| abstract_inverted_index.might | 265 |
| abstract_inverted_index.motor | 120 |
| abstract_inverted_index.study | 246 |
| abstract_inverted_index.their | 181 |
| abstract_inverted_index.three | 152 |
| abstract_inverted_index.using | 254 |
| abstract_inverted_index.Index, | 71 |
| abstract_inverted_index.Index. | 75 |
| abstract_inverted_index.Search | 70 |
| abstract_inverted_index.acting | 45 |
| abstract_inverted_index.affect | 266 |
| abstract_inverted_index.animal | 131 |
| abstract_inverted_index.assess | 33, 260 |
| abstract_inverted_index.common | 18 |
| abstract_inverted_index.course | 282 |
| abstract_inverted_index.design | 173, 247 |
| abstract_inverted_index.effect | 158 |
| abstract_inverted_index.issues | 176 |
| abstract_inverted_index.modify | 38 |
| abstract_inverted_index.number | 24 |
| abstract_inverted_index.option | 7 |
| abstract_inverted_index.shared | 255 |
| abstract_inverted_index.trials | 192, 279 |
| abstract_inverted_index.(88.4%) | 228 |
| abstract_inverted_index.Further | 252 |
| abstract_inverted_index.PubMed, | 64 |
| abstract_inverted_index.Science | 73 |
| abstract_inverted_index.Studies | 116 |
| abstract_inverted_index.ability | 182 |
| abstract_inverted_index.applied | 82 |
| abstract_inverted_index.changes | 123 |
| abstract_inverted_index.disease | 13 |
| abstract_inverted_index.effect, | 236 |
| abstract_inverted_index.effects | 113 |
| abstract_inverted_index.history | 41 |
| abstract_inverted_index.limited | 180 |
| abstract_inverted_index.models, | 132 |
| abstract_inverted_index.natural | 40 |
| abstract_inverted_index.needed. | 289 |
| abstract_inverted_index.records | 143 |
| abstract_inverted_index.several | 178, 238 |
| abstract_inverted_index.showing | 241 |
| abstract_inverted_index.studies | 26, 129, 135, 146, 153, 179, 219, 227, 253 |
| abstract_inverted_index.treated | 101 |
| abstract_inverted_index.Academic | 69 |
| abstract_inverted_index.Citation | 74 |
| abstract_inverted_index.However, | 21, 161 |
| abstract_inverted_index.November | 55 |
| abstract_inverted_index.Relevant | 50 |
| abstract_inverted_index.Reviews, | 126 |
| abstract_inverted_index.clinical | 122, 278 |
| abstract_inverted_index.criteria | 80 |
| abstract_inverted_index.enrolled | 220 |
| abstract_inverted_index.examined | 28 |
| abstract_inverted_index.existing | 274 |
| abstract_inverted_index.focusing | 117 |
| abstract_inverted_index.observed | 166, 207 |
| abstract_inverted_index.patients | 208, 287 |
| abstract_inverted_index.reported | 229 |
| abstract_inverted_index.reports, | 128 |
| abstract_inverted_index.searched | 59 |
| abstract_inverted_index.selected | 89 |
| abstract_inverted_index.subjects | 97, 194 |
| abstract_inverted_index.surgical | 203 |
| abstract_inverted_index.versions | 86 |
| abstract_inverted_index.Moreover, | 215 |
| abstract_inverted_index.articles: | 90 |
| abstract_inverted_index.criteria. | 150 |
| abstract_inverted_index.databases | 61 |
| abstract_inverted_index.described | 154 |
| abstract_inverted_index.examining | 280 |
| abstract_inverted_index.excluded. | 125 |
| abstract_inverted_index.features. | 187 |
| abstract_inverted_index.following | 77 |
| abstract_inverted_index.full-text | 85 |
| abstract_inverted_index.important | 5 |
| abstract_inverted_index.inclusion | 79, 149 |
| abstract_inverted_index.patients. | 223, 251 |
| abstract_inverted_index.potential | 156, 185 |
| abstract_inverted_index.processes | 31 |
| abstract_inverted_index.published | 52 |
| abstract_inverted_index.screened, | 144 |
| abstract_inverted_index.treatment | 6 |
| abstract_inverted_index.Deep-Brain | 0 |
| abstract_inverted_index.Knowledge, | 68 |
| abstract_inverted_index.biological | 30 |
| abstract_inverted_index.biomarkers | 256 |
| abstract_inverted_index.encouraged | 258 |
| abstract_inverted_index.increasing | 23 |
| abstract_inverted_index.late-stage | 221 |
| abstract_inverted_index.literature | 51 |
| abstract_inverted_index.management | 10 |
| abstract_inverted_index.monitoring | 94 |
| abstract_inverted_index.predefined | 78 |
| abstract_inverted_index.previously | 100 |
| abstract_inverted_index.recruiting | 92 |
| abstract_inverted_index.treatment. | 20 |
| abstract_inverted_index.Stimulation | 1 |
| abstract_inverted_index.biomarkers, | 170 |
| abstract_inverted_index.considered. | 139 |
| abstract_inverted_index.early-stage | 286 |
| abstract_inverted_index.epigenetic, | 110 |
| abstract_inverted_index.exclusively | 118 |
| abstract_inverted_index.followed-up | 193 |
| abstract_inverted_index.limitations | 243 |
| abstract_inverted_index.literature, | 276 |
| abstract_inverted_index.mechanisms. | 49 |
| abstract_inverted_index.preclinical | 275 |
| abstract_inverted_index.progression | 268 |
| abstract_inverted_index.prospective | 277 |
| abstract_inverted_index.recruitment | 249 |
| abstract_inverted_index.symptomatic | 19, 235 |
| abstract_inverted_index.biochemical, | 109 |
| abstract_inverted_index.investigated | 169 |
| abstract_inverted_index.neuroimaging | 112 |
| abstract_inverted_index.Parkinson’s | 12 |
| abstract_inverted_index.Specifically, | 188 |
| abstract_inverted_index.computational | 134 |
| abstract_inverted_index.heterogeneity | 164 |
| abstract_inverted_index.intervention, | 204 |
| abstract_inverted_index.investigating | 106 |
| abstract_inverted_index.methodological | 175 |
| abstract_inverted_index.systematically | 58 |
| abstract_inverted_index.disease-modifying | 157, 186 |
| abstract_inverted_index.pathophysiological | 48 |
| abstract_inverted_index.electrophysiological, | 108 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| citation_normalized_percentile.value | 0.0736187 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |