A Systematic Review of Vitamin D during Pregnancy and Postnatally and Symptoms of Depression in the Antenatal and Postpartum Period from Randomized Controlled Trials and Observational Studies Article Swipe
Jacqueline F. Gould
,
Robert A. Gibson
,
Tim Green
,
Maria Makrides
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/nu14112300
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/nu14112300
Depression is a common mood disorder associated with childbirth and is hypothesized to be affected by low vitamin D. This systematic review identified two randomized controlled trials (RCT) of vitamin D supplementation for the treatment or prevention of depressive symptoms in the perinatal period, as well as 18 observational studies of vitamin D exposure and depression in the antenatal and postnatal periods. Both RCTs claimed an improvement in depressive symptoms in the vitamin D group, although the sample sizes were too small to draw firm conclusions. The case-control and cohort studies had mixed findings and were limited by study quality. There were inconsistent results within the few studies with a more robust methodology or within samples restricted to women likely to have depression. The current evidence is inconclusive due to the poor quality and heterogeneity of studies, likely contributing to the contradictory findings. Given there are already numerous RCTs of prenatal vitamin D supplementation, we recommend adding an appropriate measure of depression in the perinatal period to assist in resolving the uncertainty.
Related Topics
Concepts
Randomized controlled trial
Observational study
Medicine
Depression (economics)
Postpartum depression
Mood
Vitamin D and neurology
Pregnancy
Systematic review
Cohort study
Postpartum period
Childbirth
Pediatrics
Obstetrics
Psychiatry
Internal medicine
MEDLINE
Law
Political science
Genetics
Macroeconomics
Economics
Biology
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/nu14112300
- https://www.mdpi.com/2072-6643/14/11/2300/pdf?version=1653918872
- OA Status
- gold
- Cited By
- 18
- References
- 79
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4281862650
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4281862650Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/nu14112300Digital Object Identifier
- Title
-
A Systematic Review of Vitamin D during Pregnancy and Postnatally and Symptoms of Depression in the Antenatal and Postpartum Period from Randomized Controlled Trials and Observational StudiesWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-05-30Full publication date if available
- Authors
-
Jacqueline F. Gould, Robert A. Gibson, Tim Green, Maria MakridesList of authors in order
- Landing page
-
https://doi.org/10.3390/nu14112300Publisher landing page
- PDF URL
-
https://www.mdpi.com/2072-6643/14/11/2300/pdf?version=1653918872Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2072-6643/14/11/2300/pdf?version=1653918872Direct OA link when available
- Concepts
-
Randomized controlled trial, Observational study, Medicine, Depression (economics), Postpartum depression, Mood, Vitamin D and neurology, Pregnancy, Systematic review, Cohort study, Postpartum period, Childbirth, Pediatrics, Obstetrics, Psychiatry, Internal medicine, MEDLINE, Law, Political science, Genetics, Macroeconomics, Economics, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
18Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 9, 2024: 7, 2023: 2Per-year citation counts (last 5 years)
- References (count)
-
79Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.75 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.93214743 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |