A Three-Groups Model for High-Throughput Survival Screens Article Swipe
Benjamin A. Shaby
,
Gaia Skibinski
,
D. Michael Ando
,
Eva LaDow
,
Steven Finkbeiner
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1111/biom.12479
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1111/biom.12479
Summary Amyotrophic lateral sclerosis (ALS) is a neurodegenerative condition characterized by the progressive deterioration of motor neurons in the cortex and spinal cord. Using an automated robotic microscope platform that enables the longitudinal tracking of thousands of single neurons, we examine the effects a large library of compounds on modulating the survival of primary neurons expressing a mutation known to cause ALS. The goal of our analysis is to identify the few potentially beneficial compounds among the many assayed, the vast majority of which do not extend neuronal survival. This resembles the large-scale simultaneous inference scenario familiar from microarray analysis, but transferred to the survival analysis setting due to the novel experimental setup. We apply a three-component mixture model to censored survival times of thousands of individual neurons subjected to hundreds of different compounds. The shrinkage induced by our model significantly improves performance in simulations relative to performing treatment-wise survival analysis and subsequent multiple testing adjustment. Our analysis identified compounds that provide insight into potential novel therapeutic strategies for ALS.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/biom.12479
- OA Status
- green
- Cited By
- 10
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2297968501
All OpenAlex metadata
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https://openalex.org/W2297968501Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/biom.12479Digital Object Identifier
- Title
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A Three-Groups Model for High-Throughput Survival ScreensWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2016Year of publication
- Publication date
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2016-01-28Full publication date if available
- Authors
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Benjamin A. Shaby, Gaia Skibinski, D. Michael Ando, Eva LaDow, Steven FinkbeinerList of authors in order
- Landing page
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https://doi.org/10.1111/biom.12479Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1111/biom.12479Direct OA link when available
- Concepts
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Amyotrophic lateral sclerosis, Survival analysis, Spinal cord, Cell survival, Inference, Neuroscience, Computer science, Throughput, Biology, Computational biology, Medicine, Artificial intelligence, Pathology, Disease, Internal medicine, Wireless, Biochemistry, Apoptosis, TelecommunicationsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
10Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 1, 2022: 1, 2021: 1, 2020: 2Per-year citation counts (last 5 years)
- References (count)
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31Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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