A unique mRNA decapping complex in trypanosomes Article Swipe
Susanne Krämer
,
Natalia Katarzyna Karolak
,
Johanna Odenwald
,
Bernardo Gabiatti
,
Paula Andrea Castañeda Londoño
,
Anna Zavřelová
,
Eden Ribeiro Freire
,
Kayo Schemiko Almeida
,
Silke Braune
,
Claudia Maria do Nascimento Moreira
,
Amelie Eder
,
Carina Goos
,
Mark C. Field
,
Mark Carrington
,
Fabíola Holetz
,
Maria W. Górna
,
Martin Zoltner
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/nar/gkad497
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/nar/gkad497
Removal of the mRNA 5′ cap primes transcripts for degradation and is central for regulating gene expression in eukaryotes. The canonical decapping enzyme Dcp2 is stringently controlled by assembly into a dynamic multi-protein complex together with the 5′-3′exoribonuclease Xrn1. Kinetoplastida lack Dcp2 orthologues but instead rely on the ApaH-like phosphatase ALPH1 for decapping. ALPH1 is composed of a catalytic domain flanked by C- and N-terminal extensions. We show that T. brucei ALPH1 is dimeric in vitro and functions within a complex composed of the trypanosome Xrn1 ortholog XRNA and four proteins unique to Kinetoplastida, including two RNA-binding proteins and a CMGC-family protein kinase. All ALPH1-associated proteins share a unique and dynamic localization to a structure at the posterior pole of the cell, anterior to the microtubule plus ends. XRNA affinity capture in T. cruzi recapitulates this interaction network. The ALPH1 N-terminus is not required for viability in culture, but essential for posterior pole localization. The C-terminus, in contrast, is required for localization to all RNA granule types, as well as for dimerization and interactions with XRNA and the CMGC kinase, suggesting possible regulatory mechanisms. Most significantly, the trypanosome decapping complex has a unique composition, differentiating the process from opisthokonts.
Related Topics
Concepts
Biology
Exoribonuclease
Trypanosoma brucei
Cell biology
RNA
RNA-binding protein
Messenger RNA
Phosphatase
Molecular biology
Biochemistry
Gene
RNase P
Phosphorylation
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/nar/gkad497
- https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad497/50580099/gkad497.pdf
- OA Status
- gold
- Cited By
- 13
- References
- 82
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4380423297
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4380423297Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/nar/gkad497Digital Object Identifier
- Title
-
A unique mRNA decapping complex in trypanosomesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-06-13Full publication date if available
- Authors
-
Susanne Krämer, Natalia Katarzyna Karolak, Johanna Odenwald, Bernardo Gabiatti, Paula Andrea Castañeda Londoño, Anna Zavřelová, Eden Ribeiro Freire, Kayo Schemiko Almeida, Silke Braune, Claudia Maria do Nascimento Moreira, Amelie Eder, Carina Goos, Mark C. Field, Mark Carrington, Fabíola Holetz, Maria W. Górna, Martin ZoltnerList of authors in order
- Landing page
-
https://doi.org/10.1093/nar/gkad497Publisher landing page
- PDF URL
-
https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad497/50580099/gkad497.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad497/50580099/gkad497.pdfDirect OA link when available
- Concepts
-
Biology, Exoribonuclease, Trypanosoma brucei, Cell biology, RNA, RNA-binding protein, Messenger RNA, Phosphatase, Molecular biology, Biochemistry, Gene, RNase P, PhosphorylationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
13Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 10, 2023: 2Per-year citation counts (last 5 years)
- References (count)
-
82Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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