A Whole Blood Microsampling Furosemide Assay: Development, Validation and use in a Pediatric Pharmacokinetic Study Article Swipe
Nicolas A. Bamat
,
Christina Vedar
,
Megan Reilly
,
Ganesh S. Moorthy
,
Athena F. Zuppa
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.4155/bio-2022-0063
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.4155/bio-2022-0063
Background: Furosemide is a commonly used diuretic for the treatment of edema. The pharmacokinetics of furosemide in neonates as they mature remains poorly understood. Microsampling assays facilitate research in pediatric populations. Results: We developed and validated a liquid chromatography-tandem mass spectrometry method for the quantitation of furosemide in human whole blood with volumetric absorptive microsampling (VAMS) devices (10 μl). Furosemide was stable in human whole blood VAMS under the study's assay conditions. This work established stability for furosemide for 161 days when stored as dried microsamples at -78°C. Conclusion: This method is being applied for the quantitation of furosemide in whole blood VAMS in an ongoing prospective pediatric clinical study. Representative clinical data are reported.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4155/bio-2022-0063
- OA Status
- green
- Cited By
- 3
- References
- 27
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4297252938
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4297252938Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.4155/bio-2022-0063Digital Object Identifier
- Title
-
A Whole Blood Microsampling Furosemide Assay: Development, Validation and use in a Pediatric Pharmacokinetic StudyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-08-01Full publication date if available
- Authors
-
Nicolas A. Bamat, Christina Vedar, Megan Reilly, Ganesh S. Moorthy, Athena F. ZuppaList of authors in order
- Landing page
-
https://doi.org/10.4155/bio-2022-0063Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/9540403Direct OA link when available
- Concepts
-
Furosemide, Pharmacokinetics, Whole blood, Pharmacology, Diuretic, Medicine, Chemistry, Chromatography, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 1, 2023: 1Per-year citation counts (last 5 years)
- References (count)
-
27Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4297252938 |
|---|---|
| doi | https://doi.org/10.4155/bio-2022-0063 |
| ids.doi | https://doi.org/10.4155/bio-2022-0063 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/36165919 |
| ids.openalex | https://openalex.org/W4297252938 |
| fwci | 2.72916483 |
| mesh[0].qualifier_ui | Q000379 |
| mesh[0].descriptor_ui | D001800 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | methods |
| mesh[0].descriptor_name | Blood Specimen Collection |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D002648 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Child |
| mesh[2].qualifier_ui | Q000379 |
| mesh[2].descriptor_ui | D002853 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | methods |
| mesh[2].descriptor_name | Chromatography, Liquid |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D004232 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Diuretics |
| mesh[4].qualifier_ui | Q000379 |
| mesh[4].descriptor_ui | D059788 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | methods |
| mesh[4].descriptor_name | Dried Blood Spot Testing |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D005665 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Furosemide |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D006801 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Humans |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D007231 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Infant, Newborn |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D011446 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Prospective Studies |
| mesh[9].qualifier_ui | Q000379 |
| mesh[9].descriptor_ui | D053719 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | methods |
| mesh[9].descriptor_name | Tandem Mass Spectrometry |
| mesh[10].qualifier_ui | Q000379 |
| mesh[10].descriptor_ui | D001800 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | methods |
| mesh[10].descriptor_name | Blood Specimen Collection |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D002648 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Child |
| mesh[12].qualifier_ui | Q000379 |
| mesh[12].descriptor_ui | D002853 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | methods |
| mesh[12].descriptor_name | Chromatography, Liquid |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D004232 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Diuretics |
| mesh[14].qualifier_ui | Q000379 |
| mesh[14].descriptor_ui | D059788 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | methods |
| mesh[14].descriptor_name | Dried Blood Spot Testing |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D005665 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Furosemide |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D006801 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Humans |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D007231 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Infant, Newborn |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D011446 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Prospective Studies |
| mesh[19].qualifier_ui | Q000379 |
| mesh[19].descriptor_ui | D053719 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | methods |
| mesh[19].descriptor_name | Tandem Mass Spectrometry |
| type | article |
| title | A Whole Blood Microsampling Furosemide Assay: Development, Validation and use in a Pediatric Pharmacokinetic Study |
| biblio.issue | 15 |
| biblio.volume | 14 |
| biblio.last_page | 1038 |
| biblio.first_page | 1025 |
| grants[0].funder | https://openalex.org/F4320337611 |
| grants[0].award_id | K23HD10165 |
| grants[0].funder_display_name | Eunice Kennedy Shriver National Institute of Child Health and Human Development |
| topics[0].id | https://openalex.org/T12547 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9995999932289124 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2735 |
| topics[0].subfield.display_name | Pediatrics, Perinatology and Child Health |
| topics[0].display_name | Pharmaceutical studies and practices |
| topics[1].id | https://openalex.org/T11036 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9959999918937683 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2736 |
| topics[1].subfield.display_name | Pharmacology |
| topics[1].display_name | Antibiotics Pharmacokinetics and Efficacy |
| topics[2].id | https://openalex.org/T10549 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9760000109672546 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2740 |
| topics[2].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[2].display_name | Neonatal Respiratory Health Research |
| funders[0].id | https://openalex.org/F4320337611 |
| funders[0].ror | https://ror.org/04byxyr05 |
| funders[0].display_name | Eunice Kennedy Shriver National Institute of Child Health and Human Development |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2777955127 |
| concepts[0].level | 2 |
| concepts[0].score | 0.9408146142959595 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q388801 |
| concepts[0].display_name | Furosemide |
| concepts[1].id | https://openalex.org/C112705442 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7006568312644958 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q323936 |
| concepts[1].display_name | Pharmacokinetics |
| concepts[2].id | https://openalex.org/C1621761 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5861446261405945 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7997549 |
| concepts[2].display_name | Whole blood |
| concepts[3].id | https://openalex.org/C98274493 |
| concepts[3].level | 1 |
| concepts[3].score | 0.5722335577011108 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[3].display_name | Pharmacology |
| concepts[4].id | https://openalex.org/C2779918671 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5620659589767456 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q200656 |
| concepts[4].display_name | Diuretic |
| concepts[5].id | https://openalex.org/C71924100 |
| concepts[5].level | 0 |
| concepts[5].score | 0.5425281524658203 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[5].display_name | Medicine |
| concepts[6].id | https://openalex.org/C185592680 |
| concepts[6].level | 0 |
| concepts[6].score | 0.4368608593940735 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[6].display_name | Chemistry |
| concepts[7].id | https://openalex.org/C43617362 |
| concepts[7].level | 1 |
| concepts[7].score | 0.4136381447315216 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q170050 |
| concepts[7].display_name | Chromatography |
| concepts[8].id | https://openalex.org/C126322002 |
| concepts[8].level | 1 |
| concepts[8].score | 0.2213248908519745 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[8].display_name | Internal medicine |
| keywords[0].id | https://openalex.org/keywords/furosemide |
| keywords[0].score | 0.9408146142959595 |
| keywords[0].display_name | Furosemide |
| keywords[1].id | https://openalex.org/keywords/pharmacokinetics |
| keywords[1].score | 0.7006568312644958 |
| keywords[1].display_name | Pharmacokinetics |
| keywords[2].id | https://openalex.org/keywords/whole-blood |
| keywords[2].score | 0.5861446261405945 |
| keywords[2].display_name | Whole blood |
| keywords[3].id | https://openalex.org/keywords/pharmacology |
| keywords[3].score | 0.5722335577011108 |
| keywords[3].display_name | Pharmacology |
| keywords[4].id | https://openalex.org/keywords/diuretic |
| keywords[4].score | 0.5620659589767456 |
| keywords[4].display_name | Diuretic |
| keywords[5].id | https://openalex.org/keywords/medicine |
| keywords[5].score | 0.5425281524658203 |
| keywords[5].display_name | Medicine |
| keywords[6].id | https://openalex.org/keywords/chemistry |
| keywords[6].score | 0.4368608593940735 |
| keywords[6].display_name | Chemistry |
| keywords[7].id | https://openalex.org/keywords/chromatography |
| keywords[7].score | 0.4136381447315216 |
| keywords[7].display_name | Chromatography |
| keywords[8].id | https://openalex.org/keywords/internal-medicine |
| keywords[8].score | 0.2213248908519745 |
| keywords[8].display_name | Internal medicine |
| language | en |
| locations[0].id | doi:10.4155/bio-2022-0063 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S159955403 |
| locations[0].source.issn | 1757-6180, 1757-6199 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 1757-6180 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Bioanalysis |
| locations[0].source.host_organization | https://openalex.org/P4310320316 |
| locations[0].source.host_organization_name | Future Science Ltd |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320316 |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Bioanalysis |
| locations[0].landing_page_url | https://doi.org/10.4155/bio-2022-0063 |
| locations[1].id | pmid:36165919 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Bioanalysis |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/36165919 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:9540403 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Bioanalysis |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/9540403 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5047860857 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-6427-093X |
| authorships[0].author.display_name | Nicolas A. Bamat |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I1335321130 |
| authorships[0].affiliations[0].raw_affiliation_string | Center for Clinical Pharmacology, Children's Hospital of Philadelphia, Philadelphia, PA19104, USA |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I1335321130 |
| authorships[0].affiliations[1].raw_affiliation_string | Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA19104, USA |
| authorships[0].affiliations[2].institution_ids | https://openalex.org/I1335321130 |
| authorships[0].affiliations[2].raw_affiliation_string | Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA19104, USA |
| authorships[0].institutions[0].id | https://openalex.org/I1335321130 |
| authorships[0].institutions[0].ror | https://ror.org/01z7r7q48 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I1335321130 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Children's Hospital of Philadelphia |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Nicolas A Bamat |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Center for Clinical Pharmacology, Children's Hospital of Philadelphia, Philadelphia, PA19104, USA, Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA19104, USA, Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA19104, USA |
| authorships[1].author.id | https://openalex.org/A5032161530 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-8310-4715 |
| authorships[1].author.display_name | Christina Vedar |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I1335321130 |
| authorships[1].affiliations[0].raw_affiliation_string | Center for Clinical Pharmacology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA |
| authorships[1].institutions[0].id | https://openalex.org/I1335321130 |
| authorships[1].institutions[0].ror | https://ror.org/01z7r7q48 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I1335321130 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Children's Hospital of Philadelphia |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Christina Vedar |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Center for Clinical Pharmacology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA |
| authorships[2].author.id | https://openalex.org/A5078434384 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-8746-3224 |
| authorships[2].author.display_name | Megan Reilly |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1335321130 |
| authorships[2].affiliations[0].raw_affiliation_string | Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA |
| authorships[2].institutions[0].id | https://openalex.org/I1335321130 |
| authorships[2].institutions[0].ror | https://ror.org/01z7r7q48 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I1335321130 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Children's Hospital of Philadelphia |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Megan E Reilly |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA |
| authorships[3].author.id | https://openalex.org/A5067159899 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-8779-6034 |
| authorships[3].author.display_name | Ganesh S. Moorthy |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I1335321130 |
| authorships[3].affiliations[0].raw_affiliation_string | Center for Clinical Pharmacology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USADepartment of Anesthesiology & Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I1335321130 |
| authorships[3].affiliations[1].raw_affiliation_string | Department of Anesthesiology & Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA19104, USA |
| authorships[3].institutions[0].id | https://openalex.org/I1335321130 |
| authorships[3].institutions[0].ror | https://ror.org/01z7r7q48 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I1335321130 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Children's Hospital of Philadelphia |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Ganesh S Moorthy |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Center for Clinical Pharmacology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USADepartment of Anesthesiology & Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA, Department of Anesthesiology & Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA19104, USA |
| authorships[4].author.id | https://openalex.org/A5058640471 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-8662-7474 |
| authorships[4].author.display_name | Athena F. Zuppa |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I1335321130 |
| authorships[4].affiliations[0].raw_affiliation_string | Center for Clinical Pharmacology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USADepartment of Anesthesiology & Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I1335321130 |
| authorships[4].affiliations[1].raw_affiliation_string | Department of Anesthesiology & Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA19104, USA |
| authorships[4].institutions[0].id | https://openalex.org/I1335321130 |
| authorships[4].institutions[0].ror | https://ror.org/01z7r7q48 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I1335321130 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Children's Hospital of Philadelphia |
| authorships[4].author_position | last |
| authorships[4].raw_author_name | Athena F Zuppa |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Center for Clinical Pharmacology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USADepartment of Anesthesiology & Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA, Department of Anesthesiology & Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA19104, USA |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.ncbi.nlm.nih.gov/pmc/articles/9540403 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | A Whole Blood Microsampling Furosemide Assay: Development, Validation and use in a Pediatric Pharmacokinetic Study |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T12547 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9995999932289124 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2735 |
| primary_topic.subfield.display_name | Pediatrics, Perinatology and Child Health |
| primary_topic.display_name | Pharmaceutical studies and practices |
| related_works | https://openalex.org/W2000835410, https://openalex.org/W1534820194, https://openalex.org/W2183468171, https://openalex.org/W2153370041, https://openalex.org/W2166805524, https://openalex.org/W2407715137, https://openalex.org/W2335969081, https://openalex.org/W2065731461, https://openalex.org/W1976497291, https://openalex.org/W2001290956 |
| cited_by_count | 3 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 1 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 1 |
| locations_count | 3 |
| best_oa_location.id | pmh:oai:pubmedcentral.nih.gov:9540403 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764455111 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | PubMed Central |
| best_oa_location.source.host_organization | https://openalex.org/I1299303238 |
| best_oa_location.source.host_organization_name | National Institutes of Health |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1299303238 |
| best_oa_location.license | |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | Text |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | Bioanalysis |
| best_oa_location.landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/9540403 |
| primary_location.id | doi:10.4155/bio-2022-0063 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S159955403 |
| primary_location.source.issn | 1757-6180, 1757-6199 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1757-6180 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Bioanalysis |
| primary_location.source.host_organization | https://openalex.org/P4310320316 |
| primary_location.source.host_organization_name | Future Science Ltd |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320316 |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Bioanalysis |
| primary_location.landing_page_url | https://doi.org/10.4155/bio-2022-0063 |
| publication_date | 2022-08-01 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W2111354675, https://openalex.org/W2033829367, https://openalex.org/W2947220952, https://openalex.org/W1787377049, https://openalex.org/W1995537895, https://openalex.org/W1984557526, https://openalex.org/W2133946532, https://openalex.org/W2042194526, https://openalex.org/W2039955893, https://openalex.org/W2054478999, https://openalex.org/W2415891312, https://openalex.org/W2022624634, https://openalex.org/W1966921930, https://openalex.org/W2153487427, https://openalex.org/W2952518646, https://openalex.org/W2061370625, https://openalex.org/W2004119748, https://openalex.org/W2132278266, https://openalex.org/W3025053097, https://openalex.org/W2982693705, https://openalex.org/W2152575430, https://openalex.org/W1976052384, https://openalex.org/W3205510124, https://openalex.org/W2005654864, https://openalex.org/W1138152183, https://openalex.org/W2073878312, https://openalex.org/W2166410289 |
| referenced_works_count | 27 |
| abstract_inverted_index.a | 3, 36 |
| abstract_inverted_index.We | 32 |
| abstract_inverted_index.an | 104 |
| abstract_inverted_index.as | 18, 83 |
| abstract_inverted_index.at | 86 |
| abstract_inverted_index.in | 16, 28, 47, 62, 99, 103 |
| abstract_inverted_index.is | 2, 91 |
| abstract_inverted_index.of | 10, 14, 45, 97 |
| abstract_inverted_index.(10 | 57 |
| abstract_inverted_index.161 | 79 |
| abstract_inverted_index.The | 12 |
| abstract_inverted_index.and | 34 |
| abstract_inverted_index.are | 113 |
| abstract_inverted_index.for | 7, 42, 76, 78, 94 |
| abstract_inverted_index.the | 8, 43, 68, 95 |
| abstract_inverted_index.was | 60 |
| abstract_inverted_index.This | 72, 89 |
| abstract_inverted_index.VAMS | 66, 102 |
| abstract_inverted_index.data | 112 |
| abstract_inverted_index.days | 80 |
| abstract_inverted_index.mass | 39 |
| abstract_inverted_index.they | 19 |
| abstract_inverted_index.used | 5 |
| abstract_inverted_index.when | 81 |
| abstract_inverted_index.with | 51 |
| abstract_inverted_index.work | 73 |
| abstract_inverted_index.assay | 70 |
| abstract_inverted_index.being | 92 |
| abstract_inverted_index.blood | 50, 65, 101 |
| abstract_inverted_index.dried | 84 |
| abstract_inverted_index.human | 48, 63 |
| abstract_inverted_index.under | 67 |
| abstract_inverted_index.whole | 49, 64, 100 |
| abstract_inverted_index.μl). | 58 |
| abstract_inverted_index.(VAMS) | 55 |
| abstract_inverted_index.assays | 25 |
| abstract_inverted_index.edema. | 11 |
| abstract_inverted_index.liquid | 37 |
| abstract_inverted_index.mature | 20 |
| abstract_inverted_index.method | 41, 90 |
| abstract_inverted_index.poorly | 22 |
| abstract_inverted_index.stable | 61 |
| abstract_inverted_index.stored | 82 |
| abstract_inverted_index.study. | 109 |
| abstract_inverted_index.-78°C. | 87 |
| abstract_inverted_index.applied | 93 |
| abstract_inverted_index.devices | 56 |
| abstract_inverted_index.ongoing | 105 |
| abstract_inverted_index.remains | 21 |
| abstract_inverted_index.study's | 69 |
| abstract_inverted_index.clinical | 108, 111 |
| abstract_inverted_index.commonly | 4 |
| abstract_inverted_index.diuretic | 6 |
| abstract_inverted_index.neonates | 17 |
| abstract_inverted_index.research | 27 |
| abstract_inverted_index.developed | 33 |
| abstract_inverted_index.pediatric | 29, 107 |
| abstract_inverted_index.reported. | 114 |
| abstract_inverted_index.stability | 75 |
| abstract_inverted_index.treatment | 9 |
| abstract_inverted_index.validated | 35 |
| abstract_inverted_index.Furosemide | 1, 59 |
| abstract_inverted_index.absorptive | 53 |
| abstract_inverted_index.facilitate | 26 |
| abstract_inverted_index.furosemide | 15, 46, 77, 98 |
| abstract_inverted_index.volumetric | 52 |
| abstract_inverted_index.conditions. | 71 |
| abstract_inverted_index.established | 74 |
| abstract_inverted_index.prospective | 106 |
| abstract_inverted_index.understood. | 23 |
| abstract_inverted_index.microsamples | 85 |
| abstract_inverted_index.populations. | 30 |
| abstract_inverted_index.quantitation | 44, 96 |
| abstract_inverted_index.spectrometry | 40 |
| abstract_inverted_index.Microsampling | 24 |
| abstract_inverted_index.microsampling | 54 |
| abstract_inverted_index.Representative | 110 |
| abstract_inverted_index.<b>Results:</b> | 31 |
| abstract_inverted_index.pharmacokinetics | 13 |
| abstract_inverted_index.<b>Background:</b> | 0 |
| abstract_inverted_index.<b>Conclusion:</b> | 88 |
| abstract_inverted_index.chromatography-tandem | 38 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.49000000953674316 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.80714891 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |