AB034. Single-cell RNA-seq reveals altered gene expression and cellular composition in thymic epithelial cells of type B thymoma Article Swipe
Nobuko Akiyama
,
Kano Namiki
,
Kenta Horie
,
Takahisa Miyao
,
Maki Miyauchi
,
Mizuki Morota
,
Jun Nakajima
,
Taishin Akiyama
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21037/med-24-ab034
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21037/med-24-ab034
BACKGROUND: Thymic epithelial cells (TECs) play a crucial role in thymoma pathogenesis and associated autoimmune conditions. This study aims to elucidate the alterations in gene expression and cellular composition of TECs within type B thymomas, which are often associated with autoimmune diseases. METHODS: We conducted single-cell RNA sequencing (scRNA-seq) on TECs isolated from both tumor and normal regions in type B thymoma patients. Using droplet-based scRNA-seq, we analyzed 15,062 tumor-derived TECs and 16,541 normal TECs from three patients of type B thymoma. RESULTS: Cell clustering analysis revealed increased cortical TECs (cTECs) and decreased specific subsets of medullary TECs (mTECs) in tumor regions compared to normal regions. Differential gene expression analysis further highlighted distinct transcriptional profiles between TEC subsets from tumor and normal regions. Notably, genes typically expressed in normal cTECs were aberrantly up-regulated in mTEC subsets within the tumor regions. To uncover the underlying mechanisms driving these gene expression changes, we focused on transcription factors differentially expressed in tumor TECs. Based on these insights, we established a mouse model that partially mirrors the gene expression profile observed in thymoma. This model provides a valuable tool for investigating the potential roles of these gene expression changes in thymoma-associated autoimmune diseases. CONCLUSIONS: Our findings underscore the importance of altered TEC subsets and their gene expression profiles in thymoma development and associated autoimmunity, offering new avenues for therapeutic intervention.
Related Topics
Concepts
Thymoma
Gene
RNA-Seq
Cell biology
Gene expression
Composition (language)
Biology
RNA
Cell
Cell type
Molecular biology
Genetics
Immunology
Transcriptome
Philosophy
Linguistics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.21037/med-24-ab034
- OA Status
- diamond
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405952782
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4405952782Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21037/med-24-ab034Digital Object Identifier
- Title
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AB034. Single-cell RNA-seq reveals altered gene expression and cellular composition in thymic epithelial cells of type B thymomaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-12-01Full publication date if available
- Authors
-
Nobuko Akiyama, Kano Namiki, Kenta Horie, Takahisa Miyao, Maki Miyauchi, Mizuki Morota, Jun Nakajima, Taishin AkiyamaList of authors in order
- Landing page
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https://doi.org/10.21037/med-24-ab034Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.21037/med-24-ab034Direct OA link when available
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Thymoma, Gene, RNA-Seq, Cell biology, Gene expression, Composition (language), Biology, RNA, Cell, Cell type, Molecular biology, Genetics, Immunology, Transcriptome, Philosophy, LinguisticsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.cortical | 88 |
| abstract_inverted_index.distinct | 112 |
| abstract_inverted_index.findings | 201 |
| abstract_inverted_index.isolated | 51 |
| abstract_inverted_index.observed | 176 |
| abstract_inverted_index.offering | 220 |
| abstract_inverted_index.patients | 77 |
| abstract_inverted_index.profiles | 114, 213 |
| abstract_inverted_index.provides | 181 |
| abstract_inverted_index.regions. | 105, 122, 139 |
| abstract_inverted_index.revealed | 86 |
| abstract_inverted_index.specific | 93 |
| abstract_inverted_index.thymoma. | 81, 178 |
| abstract_inverted_index.valuable | 183 |
| abstract_inverted_index.conducted | 44 |
| abstract_inverted_index.decreased | 92 |
| abstract_inverted_index.diseases. | 41, 198 |
| abstract_inverted_index.elucidate | 20 |
| abstract_inverted_index.expressed | 126, 156 |
| abstract_inverted_index.increased | 87 |
| abstract_inverted_index.insights, | 163 |
| abstract_inverted_index.medullary | 96 |
| abstract_inverted_index.partially | 170 |
| abstract_inverted_index.patients. | 62 |
| abstract_inverted_index.potential | 188 |
| abstract_inverted_index.thymomas, | 34 |
| abstract_inverted_index.typically | 125 |
| abstract_inverted_index.aberrantly | 131 |
| abstract_inverted_index.associated | 13, 38, 218 |
| abstract_inverted_index.autoimmune | 14, 40, 197 |
| abstract_inverted_index.clustering | 84 |
| abstract_inverted_index.epithelial | 2 |
| abstract_inverted_index.expression | 25, 108, 148, 174, 193, 212 |
| abstract_inverted_index.importance | 204 |
| abstract_inverted_index.mechanisms | 144 |
| abstract_inverted_index.scRNA-seq, | 65 |
| abstract_inverted_index.sequencing | 47 |
| abstract_inverted_index.underlying | 143 |
| abstract_inverted_index.underscore | 202 |
| abstract_inverted_index.(scRNA-seq) | 48 |
| abstract_inverted_index.BACKGROUND: | 0 |
| abstract_inverted_index.alterations | 22 |
| abstract_inverted_index.composition | 28 |
| abstract_inverted_index.conditions. | 15 |
| abstract_inverted_index.development | 216 |
| abstract_inverted_index.established | 165 |
| abstract_inverted_index.highlighted | 111 |
| abstract_inverted_index.single-cell | 45 |
| abstract_inverted_index.therapeutic | 224 |
| abstract_inverted_index.CONCLUSIONS: | 199 |
| abstract_inverted_index.Differential | 106 |
| abstract_inverted_index.pathogenesis | 11 |
| abstract_inverted_index.up-regulated | 132 |
| abstract_inverted_index.autoimmunity, | 219 |
| abstract_inverted_index.droplet-based | 64 |
| abstract_inverted_index.intervention. | 225 |
| abstract_inverted_index.investigating | 186 |
| abstract_inverted_index.transcription | 153 |
| abstract_inverted_index.tumor-derived | 69 |
| abstract_inverted_index.differentially | 155 |
| abstract_inverted_index.transcriptional | 113 |
| abstract_inverted_index.thymoma-associated | 196 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 8 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.6399999856948853 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.43426466 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |