Aberrant static and dynamic functional connectivity of insular cortex in patients with trigeminal neuralgia Article Swipe
Yuying Chen
,
Shumei Li
,
Meng Li
,
Lan Huang
,
Mian Jiang
,
Guo‐Min Li
,
Jinyan Chen
,
Jianhao Yan
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-025-07468-7
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-025-07468-7
The abnormal insular-related static and dynamic functional connectivity (sFC and dFC) in patients with trigeminal neuralgia (TN) is not well understood. Therefore, we aimed to explore alterations in the sFC and dFC of the insular cortex(IC) and the relationships between functional connectivity (FC) alterations and clinical measures in TN. The study included 40 patients with TN and 30 healthy controls (HCs) who underwent resting-state functional magnetic resonance imaging and completed the visual analog scale (VAS) and mood questionnaires. Voxel-based sFC and dFC in the bilateral IC were computed. For the voxel-wise FC differences between TN and HC, a two-sample t-test was performed on the individual maps in a voxel-by-voxel manner. To examine linear relationships with clinical measures, Pearson correlations were calculated between FC alterations and VAS and mood measures. Compared with HCs, patients with TN exhibited significantly decreased sFC between the bilateral IC and right superior temporal gyrus, left Rolandic operculum, left thalamus, left supramarginal gyrus, and left superior parietal gyrus, and decreased dFC between the IC and cerebellar vermis. Correlation analysis revealed negative correlations between sFC of IC-thalamus and VAS and dFC of IC-vermis and duration of pain. Our findings reveal brain regions related to pain sensation and regulation showing abnormal sFC and dFC alterations in TN, suggesting their pivotal roles in the neural mechanisms underlying TN.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-025-07468-7
- https://www.nature.com/articles/s41598-025-07468-7.pdf
- OA Status
- gold
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411872246
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411872246Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41598-025-07468-7Digital Object Identifier
- Title
-
Aberrant static and dynamic functional connectivity of insular cortex in patients with trigeminal neuralgiaWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
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2025-07-01Full publication date if available
- Authors
-
Yuying Chen, Shumei Li, Meng Li, Lan Huang, Mian Jiang, Guo‐Min Li, Jinyan Chen, Jianhao YanList of authors in order
- Landing page
-
https://doi.org/10.1038/s41598-025-07468-7Publisher landing page
- PDF URL
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https://www.nature.com/articles/s41598-025-07468-7.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://www.nature.com/articles/s41598-025-07468-7.pdfDirect OA link when available
- Concepts
-
Trigeminal neuralgia, Functional connectivity, Neuroscience, Insular cortex, Cortex (anatomy), Computer science, Medicine, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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58Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| institutions_distinct_count | 8 |
| citation_normalized_percentile.value | 0.2615611 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |