Aberrant Tryptophan Metabolism Manipulates Osteochondral Homeostasis Article Swipe
Tingwen Xiang
,
Chuan Yang
,
Langlang Xie
,
Shiyu Xiao
,
Yong Tang
,
Gang Huang
,
Dong Sun
,
Yueqi Chen
,
Fei Luo
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.34133/research.0728
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.34133/research.0728
Tryptophan (Trp), an essential amino acid, performs as a precursor for synthesizing various bioactive molecules primarily metabolized through the kynurenine (Kyn), serotonin, and indole pathways. The diverse metabolites were deeply implicated in multiple physiological processes. Emerging research has revealed the multifaceted contribution of Trp in skeletal health and pathophysiology of bone-related disease with the involvement of specific receptors including aryl hydrocarbon receptor (AhR), which modulated the downstream signaling pathways to manage the expression of pivotal genes and thereby altered cellular biological processes, such as proliferation and differentiation. Accompanied by distinct alterations in immune function, inflammatory responses, endocrine balance, and other physiological aspects, their impact and efficacy in osteochondrogenic disorders have also been well documented. Nevertheless, a thorough understanding of Trp metabolism within bone biology is currently lacking. In this review, we elucidate the complexities of Trp metabolic pathway and several metabolites, delineating their versatile modulatory roles in the physiology and pathology of osteoblasts (OBs), osteoclasts (OCs), chondrocytes, and intercellular coupling effects, as well as in the progression of osteochondral disorder. Moreover, we comprehensively delineate the regulatory mechanisms by which gut microbiota-generated indole derivatives mediate bidirectional crosstalk along the gut–bone axis. The establishment of an elaborate governing network about bone homeostasis provides a novel insight on therapeutic interventions.
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https://doi.org/10.34133/research.0728Digital Object Identifier
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Aberrant Tryptophan Metabolism Manipulates Osteochondral HomeostasisWork title
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reviewOpenAlex work type
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enPrimary language
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2025Year of publication
- Publication date
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2025-01-01Full publication date if available
- Authors
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Tingwen Xiang, Chuan Yang, Langlang Xie, Shiyu Xiao, Yong Tang, Gang Huang, Dong Sun, Yueqi Chen, Fei LuoList of authors in order
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https://doi.org/10.34133/research.0728Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.34133/research.0728Direct OA link when available
- Concepts
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Homeostasis, Tryptophan, Tryptophan Metabolism, Metabolism, Biology, Endocrinology, Genetics, Amino acidTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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| abstract_inverted_index.alterations | 90 |
| abstract_inverted_index.delineating | 141 |
| abstract_inverted_index.derivatives | 182 |
| abstract_inverted_index.documented. | 113 |
| abstract_inverted_index.homeostasis | 199 |
| abstract_inverted_index.hydrocarbon | 60 |
| abstract_inverted_index.involvement | 54 |
| abstract_inverted_index.metabolites | 27 |
| abstract_inverted_index.metabolized | 16 |
| abstract_inverted_index.osteoblasts | 152 |
| abstract_inverted_index.osteoclasts | 154 |
| abstract_inverted_index.progression | 166 |
| abstract_inverted_index.therapeutic | 205 |
| abstract_inverted_index.bone-related | 50 |
| abstract_inverted_index.complexities | 133 |
| abstract_inverted_index.contribution | 41 |
| abstract_inverted_index.inflammatory | 94 |
| abstract_inverted_index.metabolites, | 140 |
| abstract_inverted_index.multifaceted | 40 |
| abstract_inverted_index.synthesizing | 11 |
| abstract_inverted_index.Nevertheless, | 114 |
| abstract_inverted_index.bidirectional | 184 |
| abstract_inverted_index.chondrocytes, | 156 |
| abstract_inverted_index.establishment | 191 |
| abstract_inverted_index.intercellular | 158 |
| abstract_inverted_index.osteochondral | 168 |
| abstract_inverted_index.physiological | 33, 100 |
| abstract_inverted_index.proliferation | 84 |
| abstract_inverted_index.understanding | 117 |
| abstract_inverted_index.interventions. | 206 |
| abstract_inverted_index.comprehensively | 172 |
| abstract_inverted_index.pathophysiology | 48 |
| abstract_inverted_index.differentiation. | 86 |
| abstract_inverted_index.osteochondrogenic | 107 |
| abstract_inverted_index.microbiota-generated | 180 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.6800000071525574 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.23181112 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |