ABNORMAL RETINAL REFLECTIVITY TO SHORT-WAVELENGTH LIGHT IN TYPE 2 IDIOPATHIC MACULAR TELANGIECTASIA Article Swipe
YOU?
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· 2017
· Open Access
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· DOI: https://doi.org/10.1097/iae.0000000000001728
Purpose: Macular telangiectasia Type 2 (MacTel) is a bilateral, progressive, potentially blinding retinal disease characterized by vascular and neurodegenerative signs, including an increased parafoveal reflectivity to blue light. Our aim was to investigate the relationship of this sign with other signs of macular telangiectasia Type 2 in multiple imaging modalities. Methods: Participants were selected from the MacTel Type 2 study, based on a confirmed diagnosis and the availability of images. The extent of signs in blue-light reflectance, fluorescein angiographic, optical coherence tomographic, and single- and dual-wavelength autofluorescence images were analyzed. Results: A well-defined abnormality of the perifovea is demonstrated by dual-wavelength autofluorescence and blue-light reflectance in early disease. The agreement in area size of the abnormalities in dual-wavelength autofluorescence and in blue-light reflectance images was excellent: for right eyes: ρ = 0.917 ( P < 0.0001, 95% confidence interval 0.855–0.954, n = 46) and for left eyes: ρ = 0.952 ( P < 0.0001, 95% confidence interval 0.916–0.973, n = 49). Other changes are less extensive initially and expand later to occupy that area and do not extend beyond it. Conclusion: Our findings indicate that abnormal metabolic handling of luteal pigment and physical changes giving rise to increased reflectance are widespread in the macula throughout the natural history of the disease, precede other changes, and are relevant to early diagnosis.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/iae.0000000000001728
- OA Status
- green
- Cited By
- 28
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2697781073
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2697781073Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1097/iae.0000000000001728Digital Object Identifier
- Title
-
ABNORMAL RETINAL REFLECTIVITY TO SHORT-WAVELENGTH LIGHT IN TYPE 2 IDIOPATHIC MACULAR TELANGIECTASIAWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-06-23Full publication date if available
- Authors
-
Ferenc B. Sallo, Irene Leung, Meike Zeimer, Traci E. Clemons, Adam M. Dubis, Marcus Fruttiger, Daniel Pauleikhoff, Emily Y. Chew, Catherine Egan, Tünde Pető, Alan C. BirdList of authors in order
- Landing page
-
https://doi.org/10.1097/iae.0000000000001728Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/5726908Direct OA link when available
- Concepts
-
Macular telangiectasia, Autofluorescence, Medicine, Ophthalmology, Retinal, Reflectivity, Optical coherence tomography, Telangiectasia, Fluorescein angiography, Pathology, Optics, Fluorescence, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
28Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 4, 2023: 3, 2022: 3, 2021: 4Per-year citation counts (last 5 years)
- References (count)
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29Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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