Absence of central white patch in dermatofibromas presenting in darker skin Article Swipe

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Medicine Hypopigmentation Sign (mathematics) Dermatology Dimple Materials science Metallurgy Mathematical analysis Mathematics

Tate Giddens , Elizabeth V. Seiverling , Ashfaq A. Marghoob , Richard P. Usatine ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.1016/j.jdcr.2021.12.023 · OA: W4205349154

Dermatofibromas (DFs) are benign, cutaneous lesions that most commonly present in middle-aged individuals as hyperpigmented, firm papules with central hypopigmentation. Most DFs can be diagnosed clinically based on their morphology and based on the presence of the dimple sign. DFs dimple with the application of lateral pressure, an indicator known as the Fitzpatrick sign (Fig 1). Although this sign is not unique to DFs, it is highly predictive of a DF. While the diagnosis of DFs can be straightforward, occasionally, DFs can be clinically challenging to differentiate from cutaneous malignancies.