Abstract Number ‐ 240: Association of intravenous thrombolysis and pre‐interventional reperfusion: a post‐hoc analysis of the SWIFT DIRECT trial Article Swipe
Adnan Mujanović
,
Omer Eker
,
Gaultier Marnat
,
Daniel Strbian
,
Petra Ijäs
,
Cécile Preterre
,
Aude Triquenot
,
Jean François Albucher
,
Maxime Gauberti
,
David Weisenburger‐Lile
,
Marielle Ernst
,
Omid Nikoubashman
,
Anastasios Mpotsaris
,
Benjamin Gory
,
Vi Tuan Hua
,
Marc Ribó
,
D Liebeskind
,
Tomas Dobrocky
,
Thomas R. Meinel
,
Lukas Bütikofer
,
Jan Gralla
,
Urs Fischer
,
Johannes Kaesmacher
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1161/svin.03.suppl_1.240
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1161/svin.03.suppl_1.240
Introduction One potential benefit of intravenous thrombolysis (IVT) before mechanical thrombectomy (MT) is pre‐interventional reperfusion. Currently, there is a paucity of data regarding the occurrence of pre‐interventional reperfusion in patients randomized to IVT or no‐IVT before MT. Methods SWIFT DIRECT was a randomized controlled trial including acute ischemic stroke IVT‐eligible patients being directly admitted to a comprehensive stroke center, with allocation to either MT alone or IVT + MT. Primary endpoint of this analysis was the occurrence of pre‐interventional reperfusion defined as pre‐interventional expanded Thrombolysis in Cerebral Infarction score ≥ 2a. The effect of IVT and potential treatment effect heterogeneity were analyzed using logistic regression analyses. Results Out of the 396 patients analyzed, pre‐interventional reperfusion occurred in 20 (10.0%) of patients randomized to IVT+MT, and 7 (3.6%) of patients randomized to MT alone. Receiving IVT favored the occurrence of pre‐interventional reperfusion (aOR 2.91 [95% CI 1.23 – 6.87]). There was no IVT treatment effect heterogeneity on the occurrence of pre‐interventional reperfusion with different strata of Randomization‐to‐Groin‐Puncture (p for interaction = 0.33), although the effect tended to be stronger in patients with Randomization‐to‐Groin‐Puncture >28 minutes (aOR 4.65 [95% CI 1.16 – 18.68]). There were no significant difference in rates of functional outcomes between patients with and without pre‐interventional reperfusion. Conclusions Even for patients with proximal large vessel occlusions and direct access to MT, IVT leads towards an absolute increase of 6.9% (95% CI 1.7‐12.2%) in the rates of pre‐interventional reperfusion. The effect of IVT tended to be more pronounced when Randomization‐to‐Groin‐Puncture intervals were longer, but this heterogeneity did not reach statistical significance.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1161/svin.03.suppl_1.240
- OA Status
- diamond
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4367018637
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4367018637Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1161/svin.03.suppl_1.240Digital Object Identifier
- Title
-
Abstract Number ‐ 240: Association of intravenous thrombolysis and pre‐interventional reperfusion: a post‐hoc analysis of the SWIFT DIRECT trialWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-03-01Full publication date if available
- Authors
-
Adnan Mujanović, Omer Eker, Gaultier Marnat, Daniel Strbian, Petra Ijäs, Cécile Preterre, Aude Triquenot, Jean François Albucher, Maxime Gauberti, David Weisenburger‐Lile, Marielle Ernst, Omid Nikoubashman, Anastasios Mpotsaris, Benjamin Gory, Vi Tuan Hua, Marc Ribó, D Liebeskind, Tomas Dobrocky, Thomas R. Meinel, Lukas Bütikofer, Jan Gralla, Urs Fischer, Johannes KaesmacherList of authors in order
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https://doi.org/10.1161/svin.03.suppl_1.240Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1161/svin.03.suppl_1.240Direct OA link when available
- Concepts
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Medicine, Thrombolysis, Randomization, Randomized controlled trial, Stroke (engine), Groin, Clinical endpoint, Logistic regression, Post-hoc analysis, Surgery, Internal medicine, Anesthesia, Myocardial infarction, Engineering, Mechanical engineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.direct | 218 |
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| abstract_inverted_index.Randomization‐to‐Groin‐Puncture | 165, 181, 249 |
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| institutions_distinct_count | 23 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
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| citation_normalized_percentile.is_in_top_10_percent | False |