Accelerated telomere shortening independent of LRRK2 variants in Chinese patients with Parkinson's disease Article Swipe
Yue Wu
,
Yuqing Pei
,
Zhuo Yang
,
Kexin Li
,
Xiaoying Lou
,
Wei Cui
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.18632/aging.103878
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.18632/aging.103878
Oxidative stress and inflammation play vital roles in Parkinson's disease (PD) development. Thus, telomere length is expected to be shortened in this disease, but current data are inconclusive. We performed a case-control study of 261 patients with PD and 270 sex and age-matched healthy controls treated at the Peking Union Medical College Hospital. We found leucocyte telomere length (LTL) was significantly shortened in PD as compared with controls [1.02 (0.84-1.39) vs. 1.48 (1.08-1.94), P<0.001] and shorter LTL was associated with a dramatically increased risk of PD (lowest vs. highest quartile odds ratio (OR) =9.54, 95% CI: 5.33-17.06, P<0.001). We also investigated the roles of six LRRK2 variants in the susceptibility to PD. R1441C/G/H, G2019S, and I2020T variations were not detected in our study. No significant differences were found in the presence of variants R1398H (15.4% vs. 17.0%, P=0.619) and R1628P (2.3% vs. 0.7%, P=0.159) in PD and controls, while the G2385R variant was found to be a risk factor associated with increased PD susceptibility (OR=2.14, 95% CI: 1.12-4.10, P=0.021). No significant association was found between different LRRK2 variants and telomere length. These findings suggest that shorter LTL might be associated with PD in a manner independent of LRRK2 variants.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.18632/aging.103878
- OA Status
- green
- Cited By
- 10
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3097327066Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.18632/aging.103878Digital Object Identifier
- Title
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Accelerated telomere shortening independent of LRRK2 variants in Chinese patients with Parkinson's diseaseWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-10-29Full publication date if available
- Authors
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Yue Wu, Yuqing Pei, Zhuo Yang, Kexin Li, Xiaoying Lou, Wei CuiList of authors in order
- Landing page
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https://doi.org/10.18632/aging.103878Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/7655166Direct OA link when available
- Concepts
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Telomere, LRRK2, Disease, Genetics, Parkinson's disease, Biology, Medicine, Internal medicine, GeneTop concepts (fields/topics) attached by OpenAlex
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10Total citation count in OpenAlex
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2025: 4, 2024: 1, 2023: 2, 2022: 2, 2021: 1Per-year citation counts (last 5 years)
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40Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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