Accessing the Impacts of the Calculated Panel Reactive Antibody Value on a Lung Transplant Waitlist: A Latin American Experience Article Swipe
Samuel Lucas dos Santos
,
Flávio Pola dos Reis
,
Luís Gustavo Abdalla
,
Lucas Matos Fernandes
,
Elissa Ayumi Okuno
,
Priscila Cilene León Bueno de Camargo
,
Rafael Medeiros Carraro
,
Sílvia Vidal Campos
,
Ricardo Henrique de Oliveira Braga Teixeira
,
Paulo Manuel Pêgo‐Fernandes
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/jcm14124344
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/jcm14124344
Backgorund\Objectives: Lung transplantation is the definitive treatment for select patients with end-stage pulmonary diseases. However, immunologic sensitization, as measured by calculated panel-reactive antibody (cPRA), poses significant challenges to transplant access and outcomes. This study aimed to evaluate the impact of cPRA on lung transplantation waitlist dynamics in a single-center cohort in Brazil, focusing on its association with waitlist mortality, delisting, and transplantation. Methods: A retrospective cohort study was conducted including all lung transplant candidates listed in our institution between January 2012 and December 2022. Candidates were stratified by cPRA values at listing into five groups: 0%, 0.1–25%, 25.1–50%, 50.1–75%, and 75.1–100%. Primary outcomes included lung transplantation, with secondary outcomes of waitlist mortality and delisting due to clinical deterioration. Statistical comparisons were performed, as appropriate. Results: Of the 411 candidates evaluated, 327 met the inclusion criteria. Among them, 100 (30.6%) were sensitized (cPRA > 0%), with increasing cPRA values correlating with longer median waitlist times (p < 0.01). Although transplantation rates were not statistically different across the cPRA strata (p = 0.277), the group with a cPRA > 75% had the lowest transplant rate (37.5%). Waitlist mortality was significantly higher in candidates with a cPRA > 50% (p = 0.047), whereas delisting rates did not differ across groups (p = 0.722). Conclusions: Elevated cPRA is associated with prolonged waitlist time and increased mortality, reflecting both immunologic and logistical barriers to lung transplantation. These findings support the need for incorporating cPRA into allocation policies and adopting targeted strategies, such as desensitization protocols, to improve equity in transplant access for sensitized patients, particularly in genetically diverse populations. Further multicenter studies are warranted to validate these results and inform policy development.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm14124344
- https://www.mdpi.com/2077-0383/14/12/4344/pdf?version=1750248791
- OA Status
- gold
- References
- 19
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411415405
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411415405Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/jcm14124344Digital Object Identifier
- Title
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Accessing the Impacts of the Calculated Panel Reactive Antibody Value on a Lung Transplant Waitlist: A Latin American ExperienceWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-06-18Full publication date if available
- Authors
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Samuel Lucas dos Santos, Flávio Pola dos Reis, Luís Gustavo Abdalla, Lucas Matos Fernandes, Elissa Ayumi Okuno, Priscila Cilene León Bueno de Camargo, Rafael Medeiros Carraro, Sílvia Vidal Campos, Ricardo Henrique de Oliveira Braga Teixeira, Paulo Manuel Pêgo‐FernandesList of authors in order
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https://doi.org/10.3390/jcm14124344Publisher landing page
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https://www.mdpi.com/2077-0383/14/12/4344/pdf?version=1750248791Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2077-0383/14/12/4344/pdf?version=1750248791Direct OA link when available
- Concepts
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Medicine, Latin Americans, Panel reactive antibody, Value (mathematics), Internal medicine, Oncology, Intensive care medicine, Transplantation, Statistics, Philosophy, Kidney transplantation, Mathematics, LinguisticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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19Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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