Accounting for differences between Infinium MethylationEPIC v2 and v1 in DNA methylation–based tools Article Swipe
Beryl C Zhuang
,
Marcia Smiti Jude
,
Chaini Konwar
,
Natan Yusupov
,
Calen P. Ryan
,
Hannah-Ruth Engelbrecht
,
Joanne Whitehead
,
Alexandra A. Halberstam
,
Julia L. MacIsaac
,
Kristy Dever
,
Trần Khánh Toàn
,
Kim Korinek
,
Zachary Zimmer
,
Sang Lee
,
Thomas W. McDade
,
Christopher W. Kuzawa
,
Kim M. Huffman
,
Daniel W. Belsky
,
Elisabeth B. Binder
,
Darina Czamara
,
Keegan Korthauer
,
Michael S. Kobor
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.26508/lsa.202403155
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.26508/lsa.202403155
The recently launched Illumina Infinium MethylationEPIC v2.0 (EPICv2), successor of MethylationEPIC v1.0 (EPICv1), retains most of the probes in EPICv1, while expanding coverage of regulatory elements. The concordance between the two EPIC versions in DNA methylation–based tools has not yet been investigated. To address this, DNA methylation was profiled on both versions using matched blood samples across four cohorts spanning early to late adulthood. High concordance between versions at the array level but variable agreement at the individual probe level was noted. A significant contribution of the EPIC version to DNA methylation variation was observed, though it was to a smaller extent compared with sample relatedness and cell-type composition. Modest but significant differences in DNA methylation–based estimates between versions were observed, irrespective of the data preprocessing method used. Adjustments for EPIC version or calculation of estimates separately for each version largely mitigated these version-specific discordances. This work emphasizes the importance of accounting for EPIC version differences in research scenarios, especially in meta-analyses and longitudinal studies that require data harmonization across versions.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.26508/lsa.202403155
- OA Status
- gold
- Cited By
- 2
- References
- 7
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412157176
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4412157176Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.26508/lsa.202403155Digital Object Identifier
- Title
-
Accounting for differences between Infinium MethylationEPIC v2 and v1 in DNA methylation–based toolsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-07-08Full publication date if available
- Authors
-
Beryl C Zhuang, Marcia Smiti Jude, Chaini Konwar, Natan Yusupov, Calen P. Ryan, Hannah-Ruth Engelbrecht, Joanne Whitehead, Alexandra A. Halberstam, Julia L. MacIsaac, Kristy Dever, Trần Khánh Toàn, Kim Korinek, Zachary Zimmer, Sang Lee, Thomas W. McDade, Christopher W. Kuzawa, Kim M. Huffman, Daniel W. Belsky, Elisabeth B. Binder, Darina Czamara, Keegan Korthauer, Michael S. KoborList of authors in order
- Landing page
-
https://doi.org/10.26508/lsa.202403155Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.26508/lsa.202403155Direct OA link when available
- Concepts
-
DNA methylation, Business, Environmental science, Accounting, Biology, Genetics, Gene, Gene expressionTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
7Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4412157176 |
|---|---|
| doi | https://doi.org/10.26508/lsa.202403155 |
| ids.doi | https://doi.org/10.26508/lsa.202403155 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40628445 |
| ids.openalex | https://openalex.org/W4412157176 |
| fwci | 5.36588926 |
| mesh[0].qualifier_ui | Q000235 |
| mesh[0].descriptor_ui | D019175 |
| mesh[0].is_major_topic | True |
| mesh[0].qualifier_name | genetics |
| mesh[0].descriptor_name | DNA Methylation |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D006801 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Humans |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D005260 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Female |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D008297 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Male |
| mesh[4].qualifier_ui | Q000235 |
| mesh[4].descriptor_ui | D018899 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | genetics |
| mesh[4].descriptor_name | CpG Islands |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D000328 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Adult |
| mesh[6].qualifier_ui | Q000379 |
| mesh[6].descriptor_ui | D057890 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | methods |
| mesh[6].descriptor_name | Epigenomics |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D044127 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Epigenesis, Genetic |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D008875 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Middle Aged |
| mesh[9].qualifier_ui | Q000379 |
| mesh[9].descriptor_ui | D020411 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | methods |
| mesh[9].descriptor_name | Oligonucleotide Array Sequence Analysis |
| mesh[10].qualifier_ui | Q000235 |
| mesh[10].descriptor_ui | D019175 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | genetics |
| mesh[10].descriptor_name | DNA Methylation |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D006801 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Humans |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D005260 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Female |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D008297 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Male |
| mesh[14].qualifier_ui | Q000235 |
| mesh[14].descriptor_ui | D018899 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | genetics |
| mesh[14].descriptor_name | CpG Islands |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D000328 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Adult |
| mesh[16].qualifier_ui | Q000379 |
| mesh[16].descriptor_ui | D057890 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | methods |
| mesh[16].descriptor_name | Epigenomics |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D044127 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Epigenesis, Genetic |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D008875 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Middle Aged |
| mesh[19].qualifier_ui | Q000379 |
| mesh[19].descriptor_ui | D020411 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | methods |
| mesh[19].descriptor_name | Oligonucleotide Array Sequence Analysis |
| mesh[20].qualifier_ui | Q000235 |
| mesh[20].descriptor_ui | D019175 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | genetics |
| mesh[20].descriptor_name | DNA Methylation |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D006801 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Humans |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D005260 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Female |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D008297 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Male |
| mesh[24].qualifier_ui | Q000235 |
| mesh[24].descriptor_ui | D018899 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | genetics |
| mesh[24].descriptor_name | CpG Islands |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D000328 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Adult |
| mesh[26].qualifier_ui | Q000379 |
| mesh[26].descriptor_ui | D057890 |
| mesh[26].is_major_topic | True |
| mesh[26].qualifier_name | methods |
| mesh[26].descriptor_name | Epigenomics |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D044127 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Epigenesis, Genetic |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D008875 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Middle Aged |
| mesh[29].qualifier_ui | Q000379 |
| mesh[29].descriptor_ui | D020411 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | methods |
| mesh[29].descriptor_name | Oligonucleotide Array Sequence Analysis |
| mesh[30].qualifier_ui | Q000235 |
| mesh[30].descriptor_ui | D019175 |
| mesh[30].is_major_topic | True |
| mesh[30].qualifier_name | genetics |
| mesh[30].descriptor_name | DNA Methylation |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D006801 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Humans |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D005260 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Female |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D008297 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Male |
| mesh[34].qualifier_ui | Q000235 |
| mesh[34].descriptor_ui | D018899 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | genetics |
| mesh[34].descriptor_name | CpG Islands |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D000328 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Adult |
| mesh[36].qualifier_ui | Q000379 |
| mesh[36].descriptor_ui | D057890 |
| mesh[36].is_major_topic | True |
| mesh[36].qualifier_name | methods |
| mesh[36].descriptor_name | Epigenomics |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D044127 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Epigenesis, Genetic |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D008875 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Middle Aged |
| mesh[39].qualifier_ui | Q000379 |
| mesh[39].descriptor_ui | D020411 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | methods |
| mesh[39].descriptor_name | Oligonucleotide Array Sequence Analysis |
| mesh[40].qualifier_ui | Q000235 |
| mesh[40].descriptor_ui | D019175 |
| mesh[40].is_major_topic | True |
| mesh[40].qualifier_name | genetics |
| mesh[40].descriptor_name | DNA Methylation |
| mesh[41].qualifier_ui | |
| mesh[41].descriptor_ui | D006801 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | |
| mesh[41].descriptor_name | Humans |
| mesh[42].qualifier_ui | |
| mesh[42].descriptor_ui | D005260 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | |
| mesh[42].descriptor_name | Female |
| mesh[43].qualifier_ui | |
| mesh[43].descriptor_ui | D008297 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | |
| mesh[43].descriptor_name | Male |
| mesh[44].qualifier_ui | Q000235 |
| mesh[44].descriptor_ui | D018899 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | genetics |
| mesh[44].descriptor_name | CpG Islands |
| mesh[45].qualifier_ui | |
| mesh[45].descriptor_ui | D000328 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | |
| mesh[45].descriptor_name | Adult |
| mesh[46].qualifier_ui | Q000379 |
| mesh[46].descriptor_ui | D057890 |
| mesh[46].is_major_topic | True |
| mesh[46].qualifier_name | methods |
| mesh[46].descriptor_name | Epigenomics |
| mesh[47].qualifier_ui | |
| mesh[47].descriptor_ui | D044127 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | |
| mesh[47].descriptor_name | Epigenesis, Genetic |
| mesh[48].qualifier_ui | |
| mesh[48].descriptor_ui | D008875 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | |
| mesh[48].descriptor_name | Middle Aged |
| mesh[49].qualifier_ui | Q000379 |
| mesh[49].descriptor_ui | D020411 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | methods |
| mesh[49].descriptor_name | Oligonucleotide Array Sequence Analysis |
| type | article |
| title | Accounting for differences between Infinium MethylationEPIC v2 and v1 in DNA methylation–based tools |
| biblio.issue | 9 |
| biblio.volume | 8 |
| biblio.last_page | e202403155 |
| biblio.first_page | e202403155 |
| topics[0].id | https://openalex.org/T10269 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9373000264167786 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Epigenetics and DNA Methylation |
| is_xpac | False |
| apc_list.value | 3500 |
| apc_list.currency | USD |
| apc_list.value_usd | 3500 |
| apc_paid.value | 3500 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 3500 |
| concepts[0].id | https://openalex.org/C190727270 |
| concepts[0].level | 4 |
| concepts[0].score | 0.6359562277793884 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q874745 |
| concepts[0].display_name | DNA methylation |
| concepts[1].id | https://openalex.org/C144133560 |
| concepts[1].level | 0 |
| concepts[1].score | 0.5044194459915161 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q4830453 |
| concepts[1].display_name | Business |
| concepts[2].id | https://openalex.org/C39432304 |
| concepts[2].level | 0 |
| concepts[2].score | 0.38189220428466797 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q188847 |
| concepts[2].display_name | Environmental science |
| concepts[3].id | https://openalex.org/C121955636 |
| concepts[3].level | 1 |
| concepts[3].score | 0.38110822439193726 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q4116214 |
| concepts[3].display_name | Accounting |
| concepts[4].id | https://openalex.org/C86803240 |
| concepts[4].level | 0 |
| concepts[4].score | 0.18698373436927795 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[4].display_name | Biology |
| concepts[5].id | https://openalex.org/C54355233 |
| concepts[5].level | 1 |
| concepts[5].score | 0.1459384560585022 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[5].display_name | Genetics |
| concepts[6].id | https://openalex.org/C104317684 |
| concepts[6].level | 2 |
| concepts[6].score | 0.12178871035575867 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[6].display_name | Gene |
| concepts[7].id | https://openalex.org/C150194340 |
| concepts[7].level | 3 |
| concepts[7].score | 0.0 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q26972 |
| concepts[7].display_name | Gene expression |
| keywords[0].id | https://openalex.org/keywords/dna-methylation |
| keywords[0].score | 0.6359562277793884 |
| keywords[0].display_name | DNA methylation |
| keywords[1].id | https://openalex.org/keywords/business |
| keywords[1].score | 0.5044194459915161 |
| keywords[1].display_name | Business |
| keywords[2].id | https://openalex.org/keywords/environmental-science |
| keywords[2].score | 0.38189220428466797 |
| keywords[2].display_name | Environmental science |
| keywords[3].id | https://openalex.org/keywords/accounting |
| keywords[3].score | 0.38110822439193726 |
| keywords[3].display_name | Accounting |
| keywords[4].id | https://openalex.org/keywords/biology |
| keywords[4].score | 0.18698373436927795 |
| keywords[4].display_name | Biology |
| keywords[5].id | https://openalex.org/keywords/genetics |
| keywords[5].score | 0.1459384560585022 |
| keywords[5].display_name | Genetics |
| keywords[6].id | https://openalex.org/keywords/gene |
| keywords[6].score | 0.12178871035575867 |
| keywords[6].display_name | Gene |
| language | en |
| locations[0].id | doi:10.26508/lsa.202403155 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210202458 |
| locations[0].source.issn | 2575-1077 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2575-1077 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Life Science Alliance |
| locations[0].source.host_organization | |
| locations[0].source.host_organization_name | |
| locations[0].source.host_organization_lineage | |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Life Science Alliance |
| locations[0].landing_page_url | https://doi.org/10.26508/lsa.202403155 |
| locations[1].id | pmid:40628445 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Life science alliance |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40628445 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:12238762 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Life Sci Alliance |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12238762 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5109666370 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Beryl C Zhuang |
| authorships[0].countries | CA |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[0].affiliations[0].raw_affiliation_string | Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, Canada. |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I4210153200 |
| authorships[0].affiliations[1].raw_affiliation_string | British Columbia Children's Hospital Research Institute, Vancouver, Canada. |
| authorships[0].affiliations[2].institution_ids | https://openalex.org/I141945490 |
| authorships[0].affiliations[2].raw_affiliation_string | Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada. |
| authorships[0].institutions[0].id | https://openalex.org/I4210153200 |
| authorships[0].institutions[0].ror | https://ror.org/04n901w50 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210153200 |
| authorships[0].institutions[0].country_code | CA |
| authorships[0].institutions[0].display_name | BC Children's Hospital |
| authorships[0].institutions[1].id | https://openalex.org/I141945490 |
| authorships[0].institutions[1].ror | https://ror.org/03rmrcq20 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[0].institutions[1].country_code | CA |
| authorships[0].institutions[1].display_name | University of British Columbia |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Beryl C Zhuang |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | British Columbia Children's Hospital Research Institute, Vancouver, Canada., Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, Canada., Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada. |
| authorships[1].author.id | https://openalex.org/A5081023683 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Marcia Smiti Jude |
| authorships[1].countries | CA |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[1].affiliations[0].raw_affiliation_string | Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, Canada. |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I4210153200 |
| authorships[1].affiliations[1].raw_affiliation_string | British Columbia Children's Hospital Research Institute, Vancouver, Canada. |
| authorships[1].affiliations[2].institution_ids | https://openalex.org/I141945490 |
| authorships[1].affiliations[2].raw_affiliation_string | Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada. |
| authorships[1].institutions[0].id | https://openalex.org/I4210153200 |
| authorships[1].institutions[0].ror | https://ror.org/04n901w50 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210153200 |
| authorships[1].institutions[0].country_code | CA |
| authorships[1].institutions[0].display_name | BC Children's Hospital |
| authorships[1].institutions[1].id | https://openalex.org/I141945490 |
| authorships[1].institutions[1].ror | https://ror.org/03rmrcq20 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[1].institutions[1].country_code | CA |
| authorships[1].institutions[1].display_name | University of British Columbia |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Marcia Smiti Jude |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | British Columbia Children's Hospital Research Institute, Vancouver, Canada., Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, Canada., Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada. |
| authorships[2].author.id | https://openalex.org/A5036051870 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-7448-623X |
| authorships[2].author.display_name | Chaini Konwar |
| authorships[2].countries | CA |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[2].affiliations[0].raw_affiliation_string | Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada. |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I141945490 |
| authorships[2].affiliations[1].raw_affiliation_string | Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, Canada. |
| authorships[2].affiliations[2].institution_ids | https://openalex.org/I4210153200 |
| authorships[2].affiliations[2].raw_affiliation_string | British Columbia Children's Hospital Research Institute, Vancouver, Canada. |
| authorships[2].institutions[0].id | https://openalex.org/I4210153200 |
| authorships[2].institutions[0].ror | https://ror.org/04n901w50 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210153200 |
| authorships[2].institutions[0].country_code | CA |
| authorships[2].institutions[0].display_name | BC Children's Hospital |
| authorships[2].institutions[1].id | https://openalex.org/I141945490 |
| authorships[2].institutions[1].ror | https://ror.org/03rmrcq20 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[2].institutions[1].country_code | CA |
| authorships[2].institutions[1].display_name | University of British Columbia |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Chaini Konwar |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | British Columbia Children's Hospital Research Institute, Vancouver, Canada., Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, Canada., Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada. |
| authorships[3].author.id | https://openalex.org/A5022854366 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Natan Yusupov |
| authorships[3].countries | DE |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210145969 |
| authorships[3].affiliations[0].raw_affiliation_string | Department Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany. |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I4210145969 |
| authorships[3].affiliations[1].raw_affiliation_string | International Max Planck Research School for Translational Psychiatry, Munich, Germany. |
| authorships[3].institutions[0].id | https://openalex.org/I4210145969 |
| authorships[3].institutions[0].ror | https://ror.org/04dq56617 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I149899117, https://openalex.org/I4210145969 |
| authorships[3].institutions[0].country_code | DE |
| authorships[3].institutions[0].display_name | Max Planck Institute of Psychiatry |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Natan Yusupov |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany., International Max Planck Research School for Translational Psychiatry, Munich, Germany. |
| authorships[4].author.id | https://openalex.org/A5010051134 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-0550-7949 |
| authorships[4].author.display_name | Calen P. Ryan |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I78577930 |
| authorships[4].affiliations[0].raw_affiliation_string | Robert N. Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA. |
| authorships[4].institutions[0].id | https://openalex.org/I78577930 |
| authorships[4].institutions[0].ror | https://ror.org/00hj8s172 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I78577930 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Columbia University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Calen P Ryan |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Robert N. Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA. |
| authorships[5].author.id | https://openalex.org/A5020495605 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-6627-4114 |
| authorships[5].author.display_name | Hannah-Ruth Engelbrecht |
| authorships[5].countries | CA |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[5].affiliations[0].raw_affiliation_string | Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, Canada. |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I141945490 |
| authorships[5].affiliations[1].raw_affiliation_string | Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada. |
| authorships[5].affiliations[2].institution_ids | https://openalex.org/I4210153200 |
| authorships[5].affiliations[2].raw_affiliation_string | British Columbia Children's Hospital Research Institute, Vancouver, Canada. |
| authorships[5].institutions[0].id | https://openalex.org/I4210153200 |
| authorships[5].institutions[0].ror | https://ror.org/04n901w50 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210153200 |
| authorships[5].institutions[0].country_code | CA |
| authorships[5].institutions[0].display_name | BC Children's Hospital |
| authorships[5].institutions[1].id | https://openalex.org/I141945490 |
| authorships[5].institutions[1].ror | https://ror.org/03rmrcq20 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[5].institutions[1].country_code | CA |
| authorships[5].institutions[1].display_name | University of British Columbia |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Hannah-Ruth Engelbrecht |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | British Columbia Children's Hospital Research Institute, Vancouver, Canada., Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, Canada., Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada. |
| authorships[6].author.id | https://openalex.org/A5005117443 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-9602-2081 |
| authorships[6].author.display_name | Joanne Whitehead |
| authorships[6].countries | CA |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[6].affiliations[0].raw_affiliation_string | Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada. |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I4210153200 |
| authorships[6].affiliations[1].raw_affiliation_string | British Columbia Children's Hospital Research Institute, Vancouver, Canada. |
| authorships[6].affiliations[2].institution_ids | https://openalex.org/I141945490 |
| authorships[6].affiliations[2].raw_affiliation_string | Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, Canada. |
| authorships[6].institutions[0].id | https://openalex.org/I4210153200 |
| authorships[6].institutions[0].ror | https://ror.org/04n901w50 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210153200 |
| authorships[6].institutions[0].country_code | CA |
| authorships[6].institutions[0].display_name | BC Children's Hospital |
| authorships[6].institutions[1].id | https://openalex.org/I141945490 |
| authorships[6].institutions[1].ror | https://ror.org/03rmrcq20 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[6].institutions[1].country_code | CA |
| authorships[6].institutions[1].display_name | University of British Columbia |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Joanne Whitehead |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | British Columbia Children's Hospital Research Institute, Vancouver, Canada., Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, Canada., Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada. |
| authorships[7].author.id | https://openalex.org/A5010719417 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-5475-560X |
| authorships[7].author.display_name | Alexandra A. Halberstam |
| authorships[7].countries | DE, US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I136199984, https://openalex.org/I63966007 |
| authorships[7].affiliations[0].raw_affiliation_string | Harvard Medical School/MIT Institute of Technology MD-PhD Program, Boston, MA, USA. |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I4210145969 |
| authorships[7].affiliations[1].raw_affiliation_string | Department Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany. |
| authorships[7].institutions[0].id | https://openalex.org/I4210145969 |
| authorships[7].institutions[0].ror | https://ror.org/04dq56617 |
| authorships[7].institutions[0].type | facility |
| authorships[7].institutions[0].lineage | https://openalex.org/I149899117, https://openalex.org/I4210145969 |
| authorships[7].institutions[0].country_code | DE |
| authorships[7].institutions[0].display_name | Max Planck Institute of Psychiatry |
| authorships[7].institutions[1].id | https://openalex.org/I136199984 |
| authorships[7].institutions[1].ror | https://ror.org/03vek6s52 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I136199984 |
| authorships[7].institutions[1].country_code | US |
| authorships[7].institutions[1].display_name | Harvard University |
| authorships[7].institutions[2].id | https://openalex.org/I63966007 |
| authorships[7].institutions[2].ror | https://ror.org/042nb2s44 |
| authorships[7].institutions[2].type | education |
| authorships[7].institutions[2].lineage | https://openalex.org/I63966007 |
| authorships[7].institutions[2].country_code | US |
| authorships[7].institutions[2].display_name | Massachusetts Institute of Technology |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Alexandra A Halberstam |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany., Harvard Medical School/MIT Institute of Technology MD-PhD Program, Boston, MA, USA. |
| authorships[8].author.id | https://openalex.org/A5102841357 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-9063-5429 |
| authorships[8].author.display_name | Julia L. MacIsaac |
| authorships[8].countries | CA |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[8].affiliations[0].raw_affiliation_string | Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, Canada. |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I4210153200 |
| authorships[8].affiliations[1].raw_affiliation_string | British Columbia Children's Hospital Research Institute, Vancouver, Canada. |
| authorships[8].affiliations[2].institution_ids | https://openalex.org/I141945490 |
| authorships[8].affiliations[2].raw_affiliation_string | Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada. |
| authorships[8].institutions[0].id | https://openalex.org/I4210153200 |
| authorships[8].institutions[0].ror | https://ror.org/04n901w50 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210153200 |
| authorships[8].institutions[0].country_code | CA |
| authorships[8].institutions[0].display_name | BC Children's Hospital |
| authorships[8].institutions[1].id | https://openalex.org/I141945490 |
| authorships[8].institutions[1].ror | https://ror.org/03rmrcq20 |
| authorships[8].institutions[1].type | education |
| authorships[8].institutions[1].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[8].institutions[1].country_code | CA |
| authorships[8].institutions[1].display_name | University of British Columbia |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Julia L MacIsaac |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | British Columbia Children's Hospital Research Institute, Vancouver, Canada., Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, Canada., Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada. |
| authorships[9].author.id | https://openalex.org/A5078570958 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-3101-0685 |
| authorships[9].author.display_name | Kristy Dever |
| authorships[9].countries | CA |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4210153200 |
| authorships[9].affiliations[0].raw_affiliation_string | British Columbia Children's Hospital Research Institute, Vancouver, Canada. |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I141945490 |
| authorships[9].affiliations[1].raw_affiliation_string | Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada. |
| authorships[9].affiliations[2].institution_ids | https://openalex.org/I141945490 |
| authorships[9].affiliations[2].raw_affiliation_string | Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, Canada. |
| authorships[9].institutions[0].id | https://openalex.org/I4210153200 |
| authorships[9].institutions[0].ror | https://ror.org/04n901w50 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210153200 |
| authorships[9].institutions[0].country_code | CA |
| authorships[9].institutions[0].display_name | BC Children's Hospital |
| authorships[9].institutions[1].id | https://openalex.org/I141945490 |
| authorships[9].institutions[1].ror | https://ror.org/03rmrcq20 |
| authorships[9].institutions[1].type | education |
| authorships[9].institutions[1].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[9].institutions[1].country_code | CA |
| authorships[9].institutions[1].display_name | University of British Columbia |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Kristy Dever |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | British Columbia Children's Hospital Research Institute, Vancouver, Canada., Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, Canada., Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada. |
| authorships[10].author.id | https://openalex.org/A5014128490 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-5902-749X |
| authorships[10].author.display_name | Trần Khánh Toàn |
| authorships[10].countries | VN |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I189643551 |
| authorships[10].affiliations[0].raw_affiliation_string | Family Medicine Department, Hanoi Medical University, Hanoi, Vietnam. |
| authorships[10].institutions[0].id | https://openalex.org/I189643551 |
| authorships[10].institutions[0].ror | https://ror.org/01n2t3x97 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I189643551 |
| authorships[10].institutions[0].country_code | VN |
| authorships[10].institutions[0].display_name | Hanoi Medical University |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Toan Khanh Tran |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Family Medicine Department, Hanoi Medical University, Hanoi, Vietnam. |
| authorships[11].author.id | https://openalex.org/A5024989384 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-3148-1639 |
| authorships[11].author.display_name | Kim Korinek |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I223532165 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Sociology, University of Utah, Salt Lake City, UT, USA. |
| authorships[11].institutions[0].id | https://openalex.org/I223532165 |
| authorships[11].institutions[0].ror | https://ror.org/03r0ha626 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I223532165 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | University of Utah |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Kim Korinek |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Department of Sociology, University of Utah, Salt Lake City, UT, USA. |
| authorships[12].author.id | https://openalex.org/A5080498758 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-3983-3021 |
| authorships[12].author.display_name | Zachary Zimmer |
| authorships[12].countries | CA |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I179301192 |
| authorships[12].affiliations[0].raw_affiliation_string | Department of Family Studies and Gerontology, Mount Saint Vincent University, Halifax, Canada. |
| authorships[12].affiliations[1].raw_affiliation_string | Canada Research Chair, Global Aging and Community Initiative, Halifax, Canada. |
| authorships[12].institutions[0].id | https://openalex.org/I179301192 |
| authorships[12].institutions[0].ror | https://ror.org/03g3p3b82 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I179301192 |
| authorships[12].institutions[0].country_code | CA |
| authorships[12].institutions[0].display_name | Mount Saint Vincent University |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Zachary Zimmer |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Canada Research Chair, Global Aging and Community Initiative, Halifax, Canada., Department of Family Studies and Gerontology, Mount Saint Vincent University, Halifax, Canada. |
| authorships[13].author.id | https://openalex.org/A5100383483 |
| authorships[13].author.orcid | https://orcid.org/0000-0001-9701-2718 |
| authorships[13].author.display_name | Sang Lee |
| authorships[13].countries | PH |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I617233 |
| authorships[13].affiliations[0].raw_affiliation_string | USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines. |
| authorships[13].institutions[0].id | https://openalex.org/I617233 |
| authorships[13].institutions[0].ror | https://ror.org/041jw5813 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I617233 |
| authorships[13].institutions[0].country_code | PH |
| authorships[13].institutions[0].display_name | University of San Carlos |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Nanette R Lee |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines. |
| authorships[14].author.id | https://openalex.org/A5077381724 |
| authorships[14].author.orcid | https://orcid.org/0000-0001-5829-648X |
| authorships[14].author.display_name | Thomas W. McDade |
| authorships[14].countries | CA, US |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I109736498 |
| authorships[14].affiliations[0].raw_affiliation_string | Program in Child and Brain Development, Canadian Institute for Advanced Research, Toronto, Canada. |
| authorships[14].affiliations[1].institution_ids | https://openalex.org/I111979921 |
| authorships[14].affiliations[1].raw_affiliation_string | Department of Anthropology, Northwestern University, Evanston, IL, USA. |
| authorships[14].institutions[0].id | https://openalex.org/I109736498 |
| authorships[14].institutions[0].ror | https://ror.org/01sdtdd95 |
| authorships[14].institutions[0].type | facility |
| authorships[14].institutions[0].lineage | https://openalex.org/I109736498 |
| authorships[14].institutions[0].country_code | CA |
| authorships[14].institutions[0].display_name | Canadian Institute for Advanced Research |
| authorships[14].institutions[1].id | https://openalex.org/I111979921 |
| authorships[14].institutions[1].ror | https://ror.org/000e0be47 |
| authorships[14].institutions[1].type | education |
| authorships[14].institutions[1].lineage | https://openalex.org/I111979921 |
| authorships[14].institutions[1].country_code | US |
| authorships[14].institutions[1].display_name | Northwestern University |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Thomas W McDade |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Department of Anthropology, Northwestern University, Evanston, IL, USA., Program in Child and Brain Development, Canadian Institute for Advanced Research, Toronto, Canada. |
| authorships[15].author.id | https://openalex.org/A5017820742 |
| authorships[15].author.orcid | https://orcid.org/0000-0002-0649-8677 |
| authorships[15].author.display_name | Christopher W. Kuzawa |
| authorships[15].countries | US |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I111979921 |
| authorships[15].affiliations[0].raw_affiliation_string | Department of Anthropology and Institute for Policy Research, Northwestern University, Evanston, IL, USA. |
| authorships[15].institutions[0].id | https://openalex.org/I111979921 |
| authorships[15].institutions[0].ror | https://ror.org/000e0be47 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I111979921 |
| authorships[15].institutions[0].country_code | US |
| authorships[15].institutions[0].display_name | Northwestern University |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Christopher W Kuzawa |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Department of Anthropology and Institute for Policy Research, Northwestern University, Evanston, IL, USA. |
| authorships[16].author.id | https://openalex.org/A5061496543 |
| authorships[16].author.orcid | https://orcid.org/0000-0003-4708-4734 |
| authorships[16].author.display_name | Kim M. Huffman |
| authorships[16].countries | US |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I170897317 |
| authorships[16].affiliations[0].raw_affiliation_string | Duke University School of Medicine, Durham, NC, USA. |
| authorships[16].institutions[0].id | https://openalex.org/I170897317 |
| authorships[16].institutions[0].ror | https://ror.org/00py81415 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I170897317 |
| authorships[16].institutions[0].country_code | US |
| authorships[16].institutions[0].display_name | Duke University |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Kim M Huffman |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Duke University School of Medicine, Durham, NC, USA. |
| authorships[17].author.id | https://openalex.org/A5048442961 |
| authorships[17].author.orcid | https://orcid.org/0000-0001-5463-2212 |
| authorships[17].author.display_name | Daniel W. Belsky |
| authorships[17].countries | US |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I78577930 |
| authorships[17].affiliations[0].raw_affiliation_string | Robert N. Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA. |
| authorships[17].affiliations[1].institution_ids | https://openalex.org/I78577930 |
| authorships[17].affiliations[1].raw_affiliation_string | Department of Epidemiology, Columbia UniversityMailman School of Public Health, New York, NY, USA. |
| authorships[17].institutions[0].id | https://openalex.org/I78577930 |
| authorships[17].institutions[0].ror | https://ror.org/00hj8s172 |
| authorships[17].institutions[0].type | education |
| authorships[17].institutions[0].lineage | https://openalex.org/I78577930 |
| authorships[17].institutions[0].country_code | US |
| authorships[17].institutions[0].display_name | Columbia University |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Daniel W Belsky |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Department of Epidemiology, Columbia UniversityMailman School of Public Health, New York, NY, USA., Robert N. Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA. |
| authorships[18].author.id | https://openalex.org/A5017312170 |
| authorships[18].author.orcid | https://orcid.org/0000-0001-7088-6618 |
| authorships[18].author.display_name | Elisabeth B. Binder |
| authorships[18].countries | DE |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I4210145969 |
| authorships[18].affiliations[0].raw_affiliation_string | Department Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany. |
| authorships[18].institutions[0].id | https://openalex.org/I4210145969 |
| authorships[18].institutions[0].ror | https://ror.org/04dq56617 |
| authorships[18].institutions[0].type | facility |
| authorships[18].institutions[0].lineage | https://openalex.org/I149899117, https://openalex.org/I4210145969 |
| authorships[18].institutions[0].country_code | DE |
| authorships[18].institutions[0].display_name | Max Planck Institute of Psychiatry |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Elisabeth B Binder |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Department Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany. |
| authorships[19].author.id | https://openalex.org/A5024004426 |
| authorships[19].author.orcid | https://orcid.org/0000-0001-7381-904X |
| authorships[19].author.display_name | Darina Czamara |
| authorships[19].countries | DE |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I4210145969 |
| authorships[19].affiliations[0].raw_affiliation_string | Department Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany. |
| authorships[19].institutions[0].id | https://openalex.org/I4210145969 |
| authorships[19].institutions[0].ror | https://ror.org/04dq56617 |
| authorships[19].institutions[0].type | facility |
| authorships[19].institutions[0].lineage | https://openalex.org/I149899117, https://openalex.org/I4210145969 |
| authorships[19].institutions[0].country_code | DE |
| authorships[19].institutions[0].display_name | Max Planck Institute of Psychiatry |
| authorships[19].author_position | middle |
| authorships[19].raw_author_name | Darina Czamara |
| authorships[19].is_corresponding | False |
| authorships[19].raw_affiliation_strings | Department Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany. |
| authorships[20].author.id | https://openalex.org/A5005690333 |
| authorships[20].author.orcid | https://orcid.org/0000-0002-4565-1654 |
| authorships[20].author.display_name | Keegan Korthauer |
| authorships[20].countries | CA |
| authorships[20].affiliations[0].institution_ids | https://openalex.org/I4210153200 |
| authorships[20].affiliations[0].raw_affiliation_string | British Columbia Children's Hospital Research Institute, Vancouver, Canada. |
| authorships[20].affiliations[1].institution_ids | https://openalex.org/I141945490 |
| authorships[20].affiliations[1].raw_affiliation_string | Department of Statistics, Faculty of Science, University of British Columbia, Vancouver, Canada. |
| authorships[20].institutions[0].id | https://openalex.org/I4210153200 |
| authorships[20].institutions[0].ror | https://ror.org/04n901w50 |
| authorships[20].institutions[0].type | healthcare |
| authorships[20].institutions[0].lineage | https://openalex.org/I4210153200 |
| authorships[20].institutions[0].country_code | CA |
| authorships[20].institutions[0].display_name | BC Children's Hospital |
| authorships[20].institutions[1].id | https://openalex.org/I141945490 |
| authorships[20].institutions[1].ror | https://ror.org/03rmrcq20 |
| authorships[20].institutions[1].type | education |
| authorships[20].institutions[1].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[20].institutions[1].country_code | CA |
| authorships[20].institutions[1].display_name | University of British Columbia |
| authorships[20].author_position | middle |
| authorships[20].raw_author_name | Keegan Korthauer |
| authorships[20].is_corresponding | False |
| authorships[20].raw_affiliation_strings | British Columbia Children's Hospital Research Institute, Vancouver, Canada., Department of Statistics, Faculty of Science, University of British Columbia, Vancouver, Canada. |
| authorships[21].author.id | https://openalex.org/A5082761941 |
| authorships[21].author.orcid | https://orcid.org/0000-0003-4140-1743 |
| authorships[21].author.display_name | Michael S. Kobor |
| authorships[21].countries | CA |
| authorships[21].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[21].affiliations[0].raw_affiliation_string | Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada [email protected]. |
| authorships[21].affiliations[1].institution_ids | https://openalex.org/I109736498 |
| authorships[21].affiliations[1].raw_affiliation_string | Program in Child and Brain Development, Canadian Institute for Advanced Research, Toronto, Canada. |
| authorships[21].affiliations[2].institution_ids | https://openalex.org/I4210153200 |
| authorships[21].affiliations[2].raw_affiliation_string | British Columbia Children's Hospital Research Institute, Vancouver, Canada. |
| authorships[21].affiliations[3].institution_ids | https://openalex.org/I141945490 |
| authorships[21].affiliations[3].raw_affiliation_string | Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, Canada. |
| authorships[21].institutions[0].id | https://openalex.org/I4210153200 |
| authorships[21].institutions[0].ror | https://ror.org/04n901w50 |
| authorships[21].institutions[0].type | healthcare |
| authorships[21].institutions[0].lineage | https://openalex.org/I4210153200 |
| authorships[21].institutions[0].country_code | CA |
| authorships[21].institutions[0].display_name | BC Children's Hospital |
| authorships[21].institutions[1].id | https://openalex.org/I109736498 |
| authorships[21].institutions[1].ror | https://ror.org/01sdtdd95 |
| authorships[21].institutions[1].type | facility |
| authorships[21].institutions[1].lineage | https://openalex.org/I109736498 |
| authorships[21].institutions[1].country_code | CA |
| authorships[21].institutions[1].display_name | Canadian Institute for Advanced Research |
| authorships[21].institutions[2].id | https://openalex.org/I141945490 |
| authorships[21].institutions[2].ror | https://ror.org/03rmrcq20 |
| authorships[21].institutions[2].type | education |
| authorships[21].institutions[2].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[21].institutions[2].country_code | CA |
| authorships[21].institutions[2].display_name | University of British Columbia |
| authorships[21].author_position | last |
| authorships[21].raw_author_name | Michael S Kobor |
| authorships[21].is_corresponding | False |
| authorships[21].raw_affiliation_strings | British Columbia Children's Hospital Research Institute, Vancouver, Canada., Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, Canada., Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada [email protected]., Program in Child and Brain Development, Canadian Institute for Advanced Research, Toronto, Canada. |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.26508/lsa.202403155 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Accounting for differences between Infinium MethylationEPIC v2 and v1 in DNA methylation–based tools |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10269 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9373000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Epigenetics and DNA Methylation |
| related_works | https://openalex.org/W4391375266, https://openalex.org/W1979814181, https://openalex.org/W3092304831, https://openalex.org/W2341463531, https://openalex.org/W1944020248, https://openalex.org/W2011988545, https://openalex.org/W3096105463, https://openalex.org/W3021103902, https://openalex.org/W2944665627, https://openalex.org/W2104651942 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| locations_count | 3 |
| best_oa_location.id | doi:10.26508/lsa.202403155 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210202458 |
| best_oa_location.source.issn | 2575-1077 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2575-1077 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Life Science Alliance |
| best_oa_location.source.host_organization | |
| best_oa_location.source.host_organization_name | |
| best_oa_location.source.host_organization_lineage | |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Life Science Alliance |
| best_oa_location.landing_page_url | https://doi.org/10.26508/lsa.202403155 |
| primary_location.id | doi:10.26508/lsa.202403155 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210202458 |
| primary_location.source.issn | 2575-1077 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2575-1077 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Life Science Alliance |
| primary_location.source.host_organization | |
| primary_location.source.host_organization_name | |
| primary_location.source.host_organization_lineage | |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Life Science Alliance |
| primary_location.landing_page_url | https://doi.org/10.26508/lsa.202403155 |
| publication_date | 2025-07-08 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2127431419, https://openalex.org/W2081182312, https://openalex.org/W4225396384, https://openalex.org/W2529317472, https://openalex.org/W4393573272, https://openalex.org/W2591748084, https://openalex.org/W3038310877 |
| referenced_works_count | 7 |
| abstract_inverted_index.A | 82 |
| abstract_inverted_index.a | 99 |
| abstract_inverted_index.To | 42 |
| abstract_inverted_index.at | 68, 75 |
| abstract_inverted_index.in | 18, 33, 113, 156, 160 |
| abstract_inverted_index.it | 96 |
| abstract_inverted_index.of | 9, 15, 23, 85, 122, 134, 150 |
| abstract_inverted_index.on | 49 |
| abstract_inverted_index.or | 132 |
| abstract_inverted_index.to | 61, 89, 98 |
| abstract_inverted_index.DNA | 34, 45, 90, 114 |
| abstract_inverted_index.The | 0, 26 |
| abstract_inverted_index.and | 106, 162 |
| abstract_inverted_index.but | 72, 110 |
| abstract_inverted_index.for | 129, 137, 152 |
| abstract_inverted_index.has | 37 |
| abstract_inverted_index.not | 38 |
| abstract_inverted_index.the | 16, 29, 69, 76, 86, 123, 148 |
| abstract_inverted_index.two | 30 |
| abstract_inverted_index.was | 47, 80, 93, 97 |
| abstract_inverted_index.yet | 39 |
| abstract_inverted_index.EPIC | 31, 87, 130, 153 |
| abstract_inverted_index.High | 64 |
| abstract_inverted_index.This | 145 |
| abstract_inverted_index.been | 40 |
| abstract_inverted_index.both | 50 |
| abstract_inverted_index.data | 124, 167 |
| abstract_inverted_index.each | 138 |
| abstract_inverted_index.four | 57 |
| abstract_inverted_index.late | 62 |
| abstract_inverted_index.most | 14 |
| abstract_inverted_index.that | 165 |
| abstract_inverted_index.v1.0 | 11 |
| abstract_inverted_index.v2.0 | 6 |
| abstract_inverted_index.were | 119 |
| abstract_inverted_index.with | 103 |
| abstract_inverted_index.work | 146 |
| abstract_inverted_index.array | 70 |
| abstract_inverted_index.blood | 54 |
| abstract_inverted_index.early | 60 |
| abstract_inverted_index.level | 71, 79 |
| abstract_inverted_index.probe | 78 |
| abstract_inverted_index.these | 142 |
| abstract_inverted_index.this, | 44 |
| abstract_inverted_index.tools | 36 |
| abstract_inverted_index.used. | 127 |
| abstract_inverted_index.using | 52 |
| abstract_inverted_index.while | 20 |
| abstract_inverted_index.Modest | 109 |
| abstract_inverted_index.across | 56, 169 |
| abstract_inverted_index.extent | 101 |
| abstract_inverted_index.method | 126 |
| abstract_inverted_index.noted. | 81 |
| abstract_inverted_index.probes | 17 |
| abstract_inverted_index.sample | 104 |
| abstract_inverted_index.though | 95 |
| abstract_inverted_index.EPICv1, | 19 |
| abstract_inverted_index.address | 43 |
| abstract_inverted_index.between | 28, 66, 117 |
| abstract_inverted_index.cohorts | 58 |
| abstract_inverted_index.largely | 140 |
| abstract_inverted_index.matched | 53 |
| abstract_inverted_index.require | 166 |
| abstract_inverted_index.retains | 13 |
| abstract_inverted_index.samples | 55 |
| abstract_inverted_index.smaller | 100 |
| abstract_inverted_index.studies | 164 |
| abstract_inverted_index.version | 88, 131, 139, 154 |
| abstract_inverted_index.Illumina | 3 |
| abstract_inverted_index.Infinium | 4 |
| abstract_inverted_index.compared | 102 |
| abstract_inverted_index.coverage | 22 |
| abstract_inverted_index.launched | 2 |
| abstract_inverted_index.profiled | 48 |
| abstract_inverted_index.recently | 1 |
| abstract_inverted_index.research | 157 |
| abstract_inverted_index.spanning | 59 |
| abstract_inverted_index.variable | 73 |
| abstract_inverted_index.versions | 32, 51, 67, 118 |
| abstract_inverted_index.(EPICv1), | 12 |
| abstract_inverted_index.(EPICv2), | 7 |
| abstract_inverted_index.agreement | 74 |
| abstract_inverted_index.cell-type | 107 |
| abstract_inverted_index.elements. | 25 |
| abstract_inverted_index.estimates | 116, 135 |
| abstract_inverted_index.expanding | 21 |
| abstract_inverted_index.mitigated | 141 |
| abstract_inverted_index.observed, | 94, 120 |
| abstract_inverted_index.successor | 8 |
| abstract_inverted_index.variation | 92 |
| abstract_inverted_index.versions. | 170 |
| abstract_inverted_index.accounting | 151 |
| abstract_inverted_index.adulthood. | 63 |
| abstract_inverted_index.emphasizes | 147 |
| abstract_inverted_index.especially | 159 |
| abstract_inverted_index.importance | 149 |
| abstract_inverted_index.individual | 77 |
| abstract_inverted_index.regulatory | 24 |
| abstract_inverted_index.scenarios, | 158 |
| abstract_inverted_index.separately | 136 |
| abstract_inverted_index.Adjustments | 128 |
| abstract_inverted_index.calculation | 133 |
| abstract_inverted_index.concordance | 27, 65 |
| abstract_inverted_index.differences | 112, 155 |
| abstract_inverted_index.methylation | 46, 91 |
| abstract_inverted_index.relatedness | 105 |
| abstract_inverted_index.significant | 83, 111 |
| abstract_inverted_index.composition. | 108 |
| abstract_inverted_index.contribution | 84 |
| abstract_inverted_index.irrespective | 121 |
| abstract_inverted_index.longitudinal | 163 |
| abstract_inverted_index.discordances. | 144 |
| abstract_inverted_index.harmonization | 168 |
| abstract_inverted_index.investigated. | 41 |
| abstract_inverted_index.meta-analyses | 161 |
| abstract_inverted_index.preprocessing | 125 |
| abstract_inverted_index.MethylationEPIC | 5, 10 |
| abstract_inverted_index.version-specific | 143 |
| abstract_inverted_index.methylation–based | 35, 115 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| countries_distinct_count | 5 |
| institutions_distinct_count | 22 |
| citation_normalized_percentile.value | 0.92196536 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |