Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol Article Swipe
Samuel Bru
,
Lydie Michaillat Mayer
,
Geun-Don Kim
,
Danye Qiu
,
Henning Jacob Jessen
,
Andreas Mayer
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7554/elife.108181.2
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7554/elife.108181.2
Cells experience strong variations in the consumption and availability of inorganic phosphate (Pi). Since Pi is an essential macronutrient but excess Pi has negative impacts on nucleotide hydrolysis and metabolism, its concentration must be maintained in a suitable range. Conserved storage organelles, acidocalcisomes, provide this buffering function. We used acidocalcisome-like yeast vacuoles to study how such organelles are set up to for this task. Our combined in vitro and in vivo analyses revealed that their ATP-driven polyphosphate polymerase VTC converts cytosolic Pi into inorganic polyphosphates (polyP), which it transfers into the vacuole lumen. Luminal polyphosphatases immediately hydrolyse this polyP to establish a growing reservoir of vacuolar Pi. Product inhibition by this Pi pool silences the polyphosphatases, caps Pi accumulation, and favours vacuolar polyP storage. Upon cytosolic Pi scarcity, the declining inositol pyrophosphate levels activate the vacuolar Pi exporter Pho91 to replenish cytosolic Pi. In this way, acidocalcisome-like vacuoles constitute a feedback-regulated buffering system for cytosolic Pi, which the cells can switch between Pi accumulation, Pi release, and high-capacity phosphate storage through polyP.
Related Topics
Concepts
Vacuole
Polyphosphate
Cytosol
Biochemistry
Pyrophosphate
Phosphate
Inositol
Organelle
Saccharomyces cerevisiae
Yeast
Pi
Adenosine triphosphate
Nucleotide
Cell biology
Biology
Lysosome
Chemistry
Inositol phosphate
In vitro
ATP hydrolysis
Hydrolysis
In vivo
Regulator
Enzyme
Metadata
- Type
- article
- Landing Page
- https://doi.org/10.7554/elife.108181.2
- OA Status
- gold
- References
- 101
- OpenAlex ID
- https://openalex.org/W7104609788
All OpenAlex metadata
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https://openalex.org/W7104609788Canonical identifier for this work in OpenAlex
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https://doi.org/10.7554/elife.108181.2Digital Object Identifier
- Title
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Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosolWork title
- Type
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articleOpenAlex work type
- Publication year
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2025Year of publication
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2025-11-11Full publication date if available
- Authors
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Samuel Bru, Lydie Michaillat Mayer, Geun-Don Kim, Danye Qiu, Henning Jacob Jessen, Andreas MayerList of authors in order
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https://doi.org/10.7554/elife.108181.2Publisher landing page
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://doi.org/10.7554/elife.108181.2Direct OA link when available
- Concepts
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Vacuole, Polyphosphate, Cytosol, Biochemistry, Pyrophosphate, Phosphate, Inositol, Organelle, Saccharomyces cerevisiae, Yeast, Pi, Adenosine triphosphate, Nucleotide, Cell biology, Biology, Lysosome, Chemistry, Inositol phosphate, In vitro, ATP hydrolysis, Hydrolysis, In vivo, Regulator, EnzymeTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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101Number of works referenced by this work
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