Activated HLA-DR+CD38+ Effector Th1/17 Cells Distinguish Crohn’s Disease-associated Perianal Fistulas from Cryptoglandular Fistulas Article Swipe
Laura F. Ouboter
,
Ciska Lindelauf
,
Qinyue Jiang
,
Mette Schreurs
,
Tamim Abdelaal
,
Sietse J. Luk
,
Marieke C. Barnhoorn
,
Willem E. Hueting
,
Ingrid J. M. Han‐Geurts
,
Koen Peeters
,
Fabian A. Holman
,
Frits Koning
,
Andrea E. van der Meulen‐de Jong
,
María Fernanda Pascutti
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/ibd/izae103
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/ibd/izae103
Background Perianal fistulas are a debilitating complication of Crohn’s disease (CD). Due to unknown reasons, CD-associated fistulas are in general more difficult to treat than cryptoglandular fistulas (non-CD-associated). Understanding the immune cell landscape is a first step towards the development of more effective therapies for CD-associated fistulas. In this work, we characterized the composition and spatial localization of disease-associated immune cells in both types of perianal fistulas by high-dimensional analyses. Methods We applied single-cell mass cytometry (scMC), spectral flow cytometry (SFC), and imaging mass cytometry (IMC) to profile the immune compartment in CD-associated perianal fistulas and cryptoglandular fistulas. An exploratory cohort (CD fistula, n = 10; non-CD fistula, n = 5) was analyzed by scMC to unravel disease-associated immune cell types. SFC was performed on a second fistula cohort (CD, n = 10; non-CD, n = 11) to comprehensively phenotype disease-associated T helper (Th) cells. IMC was used on a third cohort (CD, n = 5) to investigate the spatial distribution/interaction of relevant immune cell subsets. Results Our analyses revealed that activated HLA-DR+CD38+ effector CD4+ T cells with a Th1/17 phenotype were significantly enriched in CD-associated compared with cryptoglandular fistulas. These cells, displaying features of proliferation, regulation, and differentiation, were also present in blood, and colocalized with other CD4+ T cells, CCR6+ B cells, and macrophages in the fistula tracts. Conclusions Overall, proliferating activated HLA-DR+CD38+ effector Th1/17 cells distinguish CD-associated from cryptoglandular perianal fistulas and are a promising biomarker in blood to discriminate between these 2 fistula types. Targeting HLA-DR and CD38-expressing CD4+ T cells may offer a potential new therapeutic strategy for CD-related fistulas.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/ibd/izae103
- https://academic.oup.com/ibdjournal/advance-article-pdf/doi/10.1093/ibd/izae103/57830021/izae103.pdf
- OA Status
- hybrid
- Cited By
- 3
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4398194866
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4398194866Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/ibd/izae103Digital Object Identifier
- Title
-
Activated HLA-DR+CD38+ Effector Th1/17 Cells Distinguish Crohn’s Disease-associated Perianal Fistulas from Cryptoglandular FistulasWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-22Full publication date if available
- Authors
-
Laura F. Ouboter, Ciska Lindelauf, Qinyue Jiang, Mette Schreurs, Tamim Abdelaal, Sietse J. Luk, Marieke C. Barnhoorn, Willem E. Hueting, Ingrid J. M. Han‐Geurts, Koen Peeters, Fabian A. Holman, Frits Koning, Andrea E. van der Meulen‐de Jong, María Fernanda PascuttiList of authors in order
- Landing page
-
https://doi.org/10.1093/ibd/izae103Publisher landing page
- PDF URL
-
https://academic.oup.com/ibdjournal/advance-article-pdf/doi/10.1093/ibd/izae103/57830021/izae103.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/ibdjournal/advance-article-pdf/doi/10.1093/ibd/izae103/57830021/izae103.pdfDirect OA link when available
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Immune system, Flow cytometry, Medicine, Immunology, Effector, T cell, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
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2025: 3Per-year citation counts (last 5 years)
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42Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| primary_location.landing_page_url | https://doi.org/10.1093/ibd/izae103 |
| publication_date | 2024-05-22 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2119331847, https://openalex.org/W2935762014, https://openalex.org/W2032533938, https://openalex.org/W1991158789, https://openalex.org/W2935880168, https://openalex.org/W2037730752, https://openalex.org/W2091024308, https://openalex.org/W6679635932, https://openalex.org/W3214197792, https://openalex.org/W2587958735, https://openalex.org/W2325342792, https://openalex.org/W3116015173, https://openalex.org/W2026116536, https://openalex.org/W1991810959, https://openalex.org/W4313646546, https://openalex.org/W2521546619, https://openalex.org/W2469858118, https://openalex.org/W2387281789, https://openalex.org/W2038536063, https://openalex.org/W2982547352, https://openalex.org/W2107665951, https://openalex.org/W2464824038, https://openalex.org/W2768365920, https://openalex.org/W3175913303, https://openalex.org/W2975634117, https://openalex.org/W2107554012, https://openalex.org/W2964691289, https://openalex.org/W4220780302, https://openalex.org/W4214558579, https://openalex.org/W3024444185, https://openalex.org/W2970463661, https://openalex.org/W2045311357, https://openalex.org/W2896246287, https://openalex.org/W2122939321, https://openalex.org/W2152390002, https://openalex.org/W2151566115, https://openalex.org/W4200596403, https://openalex.org/W2585122285, https://openalex.org/W2084338775, https://openalex.org/W2143363581, https://openalex.org/W2131225457, https://openalex.org/W2467197661 |
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