Activation of beta-adrenergic receptors upregulates the signal-to-noise ratio of auditory input in the medial prefrontal cortex and mediates auditory fear conditioning Article Swipe
Haiting Xie
,
Yueqin Tian
,
Zhongli Li
,
Kaitao Wang
,
Runtong Li
,
Yi Shang
,
Aimin Chen
,
Jian Chen
,
Jun Liu
,
Xuhong Wei
,
Xiaoya Gao
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-2532453/v1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-2532453/v1
Background: Norepinephrine (NE) is involved in auditory fear conditioning (AFC) in posttraumatic stress disorder (PTSD). However, it is still unclear how it acts on neurons. Objective: We aimed to investigate whether the activation of the β-adrenergic receptor (β-AR) improves AFC by sensitization of the prelimbic (PL) cortex at the animal, cellular and molecular levels. Methods: In vivo single-cell electrophysiological recording was used to characterize the changes in neurons in the PL cortex after AFC. Then, PL neurons were measured under inhibition with the optogenetic method and local administration of the β-AR agonist isoprenaline (ISO) or the GABAaR agonist muscimol. Western blotting and immunohistochemistry were finally used to assess molecular changes. Results: Noise and low-frequency tones induced similar AFC. The expression of β-ARs was upregulated in the PL cortex after fear conditioning. Microinjection of muscimol into the PL cortex blocked the conformation of AFC, whereas ISO injection facilitated AFC. Moreover, PL neurons can be distinguished into two types, with type I but not type II neurons responding to conditioned sound and being regulated by β-ARs. Conclusion: Our results showed that β-ARs in the PL cortex regulate conditional fear learning by activating type I PL neurons.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-2532453/v1
- https://www.researchsquare.com/article/rs-2532453/latest.pdf
- OA Status
- green
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4319300266
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Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4319300266Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-2532453/v1Digital Object Identifier
- Title
-
Activation of beta-adrenergic receptors upregulates the signal-to-noise ratio of auditory input in the medial prefrontal cortex and mediates auditory fear conditioningWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-02-07Full publication date if available
- Authors
-
Haiting Xie, Yueqin Tian, Zhongli Li, Kaitao Wang, Runtong Li, Yi Shang, Aimin Chen, Jian Chen, Jun Liu, Xuhong Wei, Xiaoya GaoList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-2532453/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-2532453/latest.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-2532453/latest.pdfDirect OA link when available
- Concepts
-
Prefrontal cortex, Neuroscience, Adrenergic receptor, Auditory cortex, Psychology, BETA (programming language), Noise (video), Receptor, Medicine, Computer science, Internal medicine, Cognition, Image (mathematics), Artificial intelligence, Programming languageTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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52Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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