Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells Article Swipe
Ramesh Chittajallu
,
Kurt Auville
,
Vivek Mahadevan
,
Massimo Lai
,
Steven Hunt
,
Daniela Calvigioni
,
Kenneth A. Pelkey
,
Kareem A. Zaghloul
,
Chris J. McBain
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.03.24.004465
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.03.24.004465
The ability to modulate the efficacy of synaptic communication between neurons constitutes an essential property critical for normal brain function. Animal models have proved invaluable in revealing a wealth of diverse cellular mechanisms underlying varied plasticity modes. However, to what extent these processes are mirrored in humans is largely uncharted thus questioning their relevance to human circuit function. In this study, we focus on neurogliaform cells, a specialized form of neuron that possess physiological features enabling them to impart a widespread inhibitory influence on neural activity. We demonstrate that this prominent neuronal subtype, embedded in both mouse and human neural circuits, undergo remarkably similar activity-dependent modulation manifesting as epochs of enhanced intrinsic excitability. In principle, these evolutionary conserved plasticity routes likely tune the extent of neurogliaform cell mediated inhibition thus constituting canonical circuit mechanisms relevant for human cognitive processing and behavior.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2020.03.24.004465
- https://www.biorxiv.org/content/biorxiv/early/2020/05/22/2020.03.24.004465.full.pdf
- OA Status
- green
- Cited By
- 7
- References
- 96
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3013495451
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3013495451Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2020.03.24.004465Digital Object Identifier
- Title
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Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cellsWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
-
2020-03-25Full publication date if available
- Authors
-
Ramesh Chittajallu, Kurt Auville, Vivek Mahadevan, Massimo Lai, Steven Hunt, Daniela Calvigioni, Kenneth A. Pelkey, Kareem A. Zaghloul, Chris J. McBainList of authors in order
- Landing page
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https://doi.org/10.1101/2020.03.24.004465Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2020/05/22/2020.03.24.004465.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2020/05/22/2020.03.24.004465.full.pdfDirect OA link when available
- Concepts
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Neuroscience, Biological neural network, Inhibitory postsynaptic potential, Synaptic plasticity, Biology, Neuron, Neuroplasticity, Function (biology), Cognition, Property (philosophy), Neuronal circuits, Psychology, Cell biology, Receptor, Epistemology, Biochemistry, PhilosophyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
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2025: 1, 2024: 1, 2023: 1, 2021: 3, 2020: 1Per-year citation counts (last 5 years)
- References (count)
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96Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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