Acute effects of hypouricemia on endothelium, oxidative stress, and arterial stiffness: A randomized, double‐blind, crossover study Article Swipe
Benjamin De Becker
,
Emeline Hupkens
,
Laurence Dewachter
,
Catherine Coremans
,
Cédric Delporte
,
Pierre Van Antwerpen
,
Thierry Franck
,
Karim Zouaoui Boudjeltia
,
Pierre Cullus
,
P. van de Borne
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.14814/phy2.15018
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.14814/phy2.15018
We hypothesized acute moderate and drastic reductions in uric acid concentration exert different effects on arterial function in healthy normotensive and hypertensive adults. Thirty-six adults (aged 58 [55;63] years) with or without primary hypertension participated in a three-way, randomized, double-blind, crossover study in which [placebo] and [febuxostat] and [febuxostat and rasburicase] were administered. Febuxostat and rasburicase reduce the uric acid concentration by xanthine oxidoreductase inhibition and uric acid degradation into allantoin, respectively. Endothelial function was assessed in response to acetylcholine, sodium nitroprusside, heating (with and without nitric oxide synthase inhibition) using a laser Doppler imager. Arterial stiffness was determined by applanation tonometry, together with blood pressure, renin-angiotensin system activity, oxidative stress, and inflammation. Uric acid concentration was 5.1 [4.1;5.9], 1.9 [1.2;2.2] and 0.2 [0.2;0.3] mg/dL with [placebo], [febuxostat] and [febuxostat-rasburicase] treatments, respectively (p < 0.0001). Febuxostat improved endothelial response to heat particularly when nitric oxide synthase was inhibited (p < 0.05) and reduced diastolic and mean arterial pressure (p = 0.008 and 0.02, respectively). The augmentation index decreased with febuxostat (ANOVA p < 0.04). Myeloperoxidase activity profoundly decreased with febuxostat combined with rasburicase (p < 0.0001). When uric acid dropped, plasmatic antioxidant capacity markedly decreased, while superoxide dismutase activity increased (p < 0.0001). Other inflammatory and oxidant markers did not differ. Acute moderate hypouricemia encompasses minor improvements in endothelial function, blood pressure, and arterial stiffness. Clinical Trial Registration: NCT03395977, https://clinicaltrials.gov/ct2/show/NCT03395977.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.14814/phy2.15018
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.14814/phy2.15018
- OA Status
- gold
- Cited By
- 10
- References
- 51
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3193771550
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3193771550Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.14814/phy2.15018Digital Object Identifier
- Title
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Acute effects of hypouricemia on endothelium, oxidative stress, and arterial stiffness: A randomized, double‐blind, crossover studyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
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2021-08-26Full publication date if available
- Authors
-
Benjamin De Becker, Emeline Hupkens, Laurence Dewachter, Catherine Coremans, Cédric Delporte, Pierre Van Antwerpen, Thierry Franck, Karim Zouaoui Boudjeltia, Pierre Cullus, P. van de BorneList of authors in order
- Landing page
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https://doi.org/10.14814/phy2.15018Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.14814/phy2.15018Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.14814/phy2.15018Direct OA link when available
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Pharmacy, Medicine, Pharmacology, Library science, Chemistry, Family medicine, Computer scienceTop concepts (fields/topics) attached by OpenAlex
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10Total citation count in OpenAlex
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2025: 3, 2024: 3, 2023: 2, 2022: 1, 2021: 1Per-year citation counts (last 5 years)
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51Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2012422029, https://openalex.org/W1516957924, https://openalex.org/W2799377773, https://openalex.org/W2611746515, https://openalex.org/W2899846335, https://openalex.org/W2009268899, https://openalex.org/W2904881732, https://openalex.org/W2769738617, https://openalex.org/W2897467548, https://openalex.org/W2991138826, https://openalex.org/W2029905662, https://openalex.org/W2344146886, https://openalex.org/W1989469421, https://openalex.org/W2067474104, https://openalex.org/W2122774388, https://openalex.org/W1757751439, https://openalex.org/W2765598589, https://openalex.org/W2769236701, https://openalex.org/W1748602285, https://openalex.org/W1969320004, https://openalex.org/W2945300393, https://openalex.org/W2166126980, https://openalex.org/W2113219354, https://openalex.org/W2538848552, https://openalex.org/W2141653683, https://openalex.org/W1987105264, https://openalex.org/W2020033798, https://openalex.org/W1991590982, https://openalex.org/W2155965977, https://openalex.org/W2607499776, https://openalex.org/W2077885706, https://openalex.org/W2049216839, https://openalex.org/W1967768253, https://openalex.org/W2161841978, https://openalex.org/W2168072390, https://openalex.org/W2532946521, https://openalex.org/W2908125758, https://openalex.org/W2527290573, https://openalex.org/W1979293107, https://openalex.org/W1955399352, https://openalex.org/W2051544630, https://openalex.org/W1574547224, https://openalex.org/W1999869967, https://openalex.org/W1971013296, https://openalex.org/W2098902636, https://openalex.org/W2064080571, https://openalex.org/W2066911756, https://openalex.org/W2904028855, https://openalex.org/W1829757098, https://openalex.org/W2607031541, https://openalex.org/W3193771550 |
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