Acute oral toxicity study of ethanol extract of Oroxylum indicum leaf in mice Article Swipe
Mohd Farhan Hanif Reduan
,
Fathin Faahimaah Abdul Hamid
,
Muhammad Luqman Nordin
,
Rumaizi Shaari
,
Ruhil Hayati Hamdan
,
Eric Lim Teik Chung
,
Tan Li Peng
,
Intan Noor Aina Kamaruzaman
,
Noramalina Noralidin
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.56808/2985-1130.3064
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.56808/2985-1130.3064
The Oroxylum indicumplant is aherbal plant commonly eaten by the locals in Malaysia while the application of herbal remedies from the plant has been inherited and passed down through generations. However, there is a lack of toxicity profiling of the plant, hence this research aimed toinvestigate acute oral toxicity ofethanol extract of O. indicumin C57BL/6 male mice at different concentrations, to determine the LD50of the plant extract. A total of twenty-five mice were randomly assigned into five experimental groups comprising the control (normal saline), vehicle (5% DMSO), low dose (1000 mg/kg bw), medium dose (2000 mg/kg bw) and high dose (5000 mg/kg bw). The extracts were administered in a single oral dose on day 1 and the mice were observed daily for mortality, physiological andbehavioural changes throughout the 14 day study period. At the end of the study, vital organs and blood samples were collected to determine the effects of the extract on the relative organ weight, tissue changes and blood profile alterations.No mortalitynor behavioural changes were recorded for 2 weeks. Results of the body weight, relative organ weight, haematological and serum biochemistry assessments showed no significant (p>0.05) changes. Nevertheless, there were significant differences in the mean corpuscular volume (MCV), urea and alanine transaminase (ALT) values but the levels were still within the normal range. Histopathological analysis of the liver and kidney tissues also revealed no striking lesions. In summary, this study indicates that O. indicumleaf ethanolic extract up to 5000 mg/kg bw did not cause any toxicological effects in the mice model and is safe to be used for therapeutic purposes.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.56808/2985-1130.3064
- https://digital.car.chula.ac.th/cgi/viewcontent.cgi?article=3064&context=tjvm
- OA Status
- bronze
- Cited By
- 6
- References
- 25
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386109949
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386109949Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.56808/2985-1130.3064Digital Object Identifier
- Title
-
Acute oral toxicity study of ethanol extract of Oroxylum indicum leaf in miceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-12-01Full publication date if available
- Authors
-
Mohd Farhan Hanif Reduan, Fathin Faahimaah Abdul Hamid, Muhammad Luqman Nordin, Rumaizi Shaari, Ruhil Hayati Hamdan, Eric Lim Teik Chung, Tan Li Peng, Intan Noor Aina Kamaruzaman, Noramalina NoralidinList of authors in order
- Landing page
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https://doi.org/10.56808/2985-1130.3064Publisher landing page
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https://digital.car.chula.ac.th/cgi/viewcontent.cgi?article=3064&context=tjvmDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
- OA URL
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https://digital.car.chula.ac.th/cgi/viewcontent.cgi?article=3064&context=tjvmDirect OA link when available
- Concepts
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Toxicity, Acute toxicity, Mean corpuscular volume, Saline, Body weight, Alanine transaminase, Oral administration, Median lethal dose, Biology, Urea, Kidney, Physiology, Pharmacology, Traditional medicine, Toxicology, Animal science, Medicine, Internal medicine, Endocrinology, Biochemistry, HemoglobinTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1, 2022: 3, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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25Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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