Adherence to Direct Oral Anticoagulants in Patients With Non-Valvular Atrial Fibrillation: A Cross-National Comparison in Six European Countries (2008–2015) Article Swipe
Mònica Sabaté
,
Xavier Vidal
,
Elena Ballarín
,
Marietta Rottenkolber
,
Sven Schmiedl
,
Birgit Grave
,
Consuelo Huerta
,
Elisa Martín‐Merino
,
D. Montero
,
Luz M. León‐Muñoz
,
Christiane Gasse
,
Nicholas Moore
,
C. Droz‐Perroteau
,
R. Lassalle
,
Mia Aakjær
,
Morten Andersen
,
Marie L. De Bruin
,
Patrick C. Souverein
,
Olaf H. Klungel
,
Helga Gardarsdóttir
,
Luisa Ibáñez
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2021.682890
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2021.682890
Aims: To describe and compare the adherence to different direct oral anticoagulants (DOACs) in eight European databases representing six countries. Methods: Longitudinal drug utilization study of new users (≥18 years) of DOACs (dabigatran, rivaroxaban, apixaban) with a diagnosis of non-valvular atrial fibrillation (2008–2015). Adherence was examined by estimating persistence, switching, and discontinuation rates at 12 months. Primary non-adherence was estimated in BIFAP and SIDIAP databases. Results: The highest persistence rate was seen for apixaban in the CPRD database (81%) and the lowest for dabigatran in the Mondriaan database (22%). The switching rate for all DOACs ranged from 2.4 to 13.1% (Mondriaan and EGB databases, respectively). Dabigatran had the highest switching rate from 5.0 to 20.0% (Mondriaan and EGB databases, respectively). The discontinuation rate for all DOACs ranged from 16.0 to 63.9% (CPRD and Bavarian CD databases, respectively). Dabigatran had the highest rate of discontinuers, except in the Bavarian CD and AOK NORDWEST databases, ranging from 23.2 to 64.6% (CPRD and Mondriaan databases, respectively). Combined primary non-adherence for examined DOACs was 11.1% in BIFAP and 14.0% in SIDIAP. There were differences in population coverage and in the type of drug data source among the databases. Conclusion: Despite the differences in the characteristics of the databases and in demographic and baseline characteristics of the included population that could explain some of the observed discrepancies, we can observe a similar pattern throughout the databases. Apixaban was the DOAC with the highest persistence. Dabigatran had the highest proportion of discontinuers and switchers at 12 months in most databases (EMA/2015/27/PH).
Related Topics
Concepts
Dabigatran
Apixaban
Medicine
Rivaroxaban
Discontinuation
Atrial fibrillation
Population
Database
Internal medicine
Warfarin
Computer science
Environmental health
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fphar.2021.682890
- OA Status
- gold
- Cited By
- 13
- References
- 57
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3208942900
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3208942900Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fphar.2021.682890Digital Object Identifier
- Title
-
Adherence to Direct Oral Anticoagulants in Patients With Non-Valvular Atrial Fibrillation: A Cross-National Comparison in Six European Countries (2008–2015)Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-11-03Full publication date if available
- Authors
-
Mònica Sabaté, Xavier Vidal, Elena Ballarín, Marietta Rottenkolber, Sven Schmiedl, Birgit Grave, Consuelo Huerta, Elisa Martín‐Merino, D. Montero, Luz M. León‐Muñoz, Christiane Gasse, Nicholas Moore, C. Droz‐Perroteau, R. Lassalle, Mia Aakjær, Morten Andersen, Marie L. De Bruin, Patrick C. Souverein, Olaf H. Klungel, Helga Gardarsdóttir, Luisa IbáñezList of authors in order
- Landing page
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https://doi.org/10.3389/fphar.2021.682890Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://doi.org/10.3389/fphar.2021.682890Direct OA link when available
- Concepts
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Dabigatran, Apixaban, Medicine, Rivaroxaban, Discontinuation, Atrial fibrillation, Population, Database, Internal medicine, Warfarin, Computer science, Environmental healthTop concepts (fields/topics) attached by OpenAlex
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13Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 2, 2023: 6, 2022: 2Per-year citation counts (last 5 years)
- References (count)
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57Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.SIDIAP | 63 |
| abstract_inverted_index.atrial | 40 |
| abstract_inverted_index.direct | 9 |
| abstract_inverted_index.except | 144 |
| abstract_inverted_index.lowest | 81 |
| abstract_inverted_index.months | 250 |
| abstract_inverted_index.ranged | 95, 126 |
| abstract_inverted_index.source | 190 |
| abstract_inverted_index.years) | 29 |
| abstract_inverted_index.(DOACs) | 12 |
| abstract_inverted_index.Despite | 195 |
| abstract_inverted_index.Primary | 56 |
| abstract_inverted_index.SIDIAP. | 176 |
| abstract_inverted_index.compare | 4 |
| abstract_inverted_index.explain | 216 |
| abstract_inverted_index.highest | 67, 108, 140, 237, 242 |
| abstract_inverted_index.months. | 55 |
| abstract_inverted_index.observe | 224 |
| abstract_inverted_index.pattern | 227 |
| abstract_inverted_index.primary | 164 |
| abstract_inverted_index.ranging | 153 |
| abstract_inverted_index.similar | 226 |
| abstract_inverted_index.Apixaban | 231 |
| abstract_inverted_index.Bavarian | 133, 147 |
| abstract_inverted_index.Combined | 163 |
| abstract_inverted_index.European | 15 |
| abstract_inverted_index.Methods: | 20 |
| abstract_inverted_index.NORDWEST | 151 |
| abstract_inverted_index.Results: | 65 |
| abstract_inverted_index.apixaban | 73 |
| abstract_inverted_index.baseline | 208 |
| abstract_inverted_index.coverage | 182 |
| abstract_inverted_index.database | 77, 87 |
| abstract_inverted_index.describe | 2 |
| abstract_inverted_index.examined | 45, 167 |
| abstract_inverted_index.included | 212 |
| abstract_inverted_index.observed | 220 |
| abstract_inverted_index.Adherence | 43 |
| abstract_inverted_index.Mondriaan | 86, 160 |
| abstract_inverted_index.adherence | 6 |
| abstract_inverted_index.apixaban) | 34 |
| abstract_inverted_index.databases | 16, 203, 253 |
| abstract_inverted_index.diagnosis | 37 |
| abstract_inverted_index.different | 8 |
| abstract_inverted_index.estimated | 59 |
| abstract_inverted_index.switchers | 247 |
| abstract_inverted_index.switching | 90, 109 |
| abstract_inverted_index.(Mondriaan | 100, 115 |
| abstract_inverted_index.Dabigatran | 105, 137, 239 |
| abstract_inverted_index.countries. | 19 |
| abstract_inverted_index.dabigatran | 83 |
| abstract_inverted_index.databases, | 103, 118, 135, 152, 161 |
| abstract_inverted_index.databases. | 64, 193, 230 |
| abstract_inverted_index.estimating | 47 |
| abstract_inverted_index.population | 181, 213 |
| abstract_inverted_index.proportion | 243 |
| abstract_inverted_index.switching, | 49 |
| abstract_inverted_index.throughout | 228 |
| abstract_inverted_index.Conclusion: | 194 |
| abstract_inverted_index.demographic | 206 |
| abstract_inverted_index.differences | 179, 197 |
| abstract_inverted_index.persistence | 68 |
| abstract_inverted_index.utilization | 23 |
| abstract_inverted_index.(dabigatran, | 32 |
| abstract_inverted_index.Longitudinal | 21 |
| abstract_inverted_index.fibrillation | 41 |
| abstract_inverted_index.non-valvular | 39 |
| abstract_inverted_index.persistence, | 48 |
| abstract_inverted_index.persistence. | 238 |
| abstract_inverted_index.representing | 17 |
| abstract_inverted_index.rivaroxaban, | 33 |
| abstract_inverted_index.discontinuers | 245 |
| abstract_inverted_index.non-adherence | 57, 165 |
| abstract_inverted_index.(2008–2015). | 42 |
| abstract_inverted_index.anticoagulants | 11 |
| abstract_inverted_index.discontinuers, | 143 |
| abstract_inverted_index.discrepancies, | 221 |
| abstract_inverted_index.respectively). | 104, 119, 136, 162 |
| abstract_inverted_index.characteristics | 200, 209 |
| abstract_inverted_index.discontinuation | 51, 121 |
| abstract_inverted_index.(EMA/2015/27/PH). | 254 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 94 |
| countries_distinct_count | 6 |
| institutions_distinct_count | 21 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/17 |
| sustainable_development_goals[0].score | 0.5199999809265137 |
| sustainable_development_goals[0].display_name | Partnerships for the goals |
| citation_normalized_percentile.value | 0.85073442 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |