Adherence to Gender Affirming Hormone Therapy in Transgender Adolescents and Adults: A Retrospective Cohort Study Article Swipe
YOU?
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· 2023
· Open Access
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· DOI: https://doi.org/10.1210/clinem/dgad306
Context Transgender and gender diverse (TGD) individuals often seek gender-affirming hormone therapy (GAHT). While receipt of GAHT has been associated with improved well-being, the risk of GAHT discontinuation and its reasons are not well known. Objective There were two main objectives: (1) To investigate the proportion of TGD individuals who discontinue therapy after an average of 4 years (maximum 19 years) since GAHT initiation; and (2) to explore reasons for GAHT discontinuation. This was a retrospective cohort study at academic centers providing care to TGD adolescents and adults. TGD individuals prescribed estradiol or testosterone between January 1, 2000, and January 1, 2019, were included. GAHT continuation was ascertained using a 2-phase process. In phase 1, Kaplan–Meier survival analyses were used to examine likelihood of GAHT discontinuation and compare discontinuation rates by age and sex assigned at birth. In phase 2, reasons for stopping GAHT were investigated by reviewing records and by contacting study participants who discontinued therapy. The main outcome measures were incidence and determinants of GAHT discontinuation. Results Among 385 eligible participants, 231 (60%) were assigned male at birth and 154 (40%) were assigned female at birth. Less than one-third of participants (n = 121) initiated GAHT prior to their 18th birthday, constituting the pediatric cohort (mean age 15 years), and the remaining 264 were included in the adult cohort (mean age 32 years). In phase 1, 6 participants (1.6%) discontinued GAHT during follow-up, and of those only 2 discontinued GAHT permanently (phase 2). Conclusion GAHT discontinuation is uncommon when therapy follows Endocrine Society guidelines. Future research should include prospective studies with long-term follow-up of individuals receiving GAHT.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1210/clinem/dgad306
- OA Status
- green
- Cited By
- 26
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4378640336
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4378640336Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1210/clinem/dgad306Digital Object Identifier
- Title
-
Adherence to Gender Affirming Hormone Therapy in Transgender Adolescents and Adults: A Retrospective Cohort StudyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-05-29Full publication date if available
- Authors
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Pranav Gupta, Briana C. Patterson, Lena Chu, Sarah Gold, Seth Amos, Howa Yeung, Michael Goodman, Vin TangprichaList of authors in order
- Landing page
-
https://doi.org/10.1210/clinem/dgad306Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/10583985Direct OA link when available
- Concepts
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Discontinuation, Medicine, Retrospective cohort study, Cohort, Transgender, Hormone therapy, Cohort study, Pediatrics, Demography, Internal medicine, Psychology, Cancer, Breast cancer, Psychoanalysis, SociologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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26Total citation count in OpenAlex
- Citations by year (recent)
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2025: 19, 2024: 5, 2023: 2Per-year citation counts (last 5 years)
- References (count)
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35Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.2000, | 98 |
| abstract_inverted_index.2019, | 102 |
| abstract_inverted_index.Among | 170 |
| abstract_inverted_index.GAHT. | 269 |
| abstract_inverted_index.There | 37 |
| abstract_inverted_index.While | 14 |
| abstract_inverted_index.adult | 220 |
| abstract_inverted_index.after | 53 |
| abstract_inverted_index.birth | 180 |
| abstract_inverted_index.often | 8 |
| abstract_inverted_index.phase | 114, 139, 227 |
| abstract_inverted_index.prior | 199 |
| abstract_inverted_index.rates | 130 |
| abstract_inverted_index.since | 62 |
| abstract_inverted_index.study | 78, 153 |
| abstract_inverted_index.their | 201 |
| abstract_inverted_index.those | 238 |
| abstract_inverted_index.using | 109 |
| abstract_inverted_index.years | 58 |
| abstract_inverted_index.(1.6%) | 231 |
| abstract_inverted_index.(phase | 244 |
| abstract_inverted_index.Future | 257 |
| abstract_inverted_index.birth. | 137, 188 |
| abstract_inverted_index.cohort | 77, 207, 221 |
| abstract_inverted_index.during | 234 |
| abstract_inverted_index.female | 186 |
| abstract_inverted_index.gender | 4 |
| abstract_inverted_index.known. | 35 |
| abstract_inverted_index.should | 259 |
| abstract_inverted_index.years) | 61 |
| abstract_inverted_index.(GAHT). | 13 |
| abstract_inverted_index.2-phase | 111 |
| abstract_inverted_index.Context | 1 |
| abstract_inverted_index.January | 96, 100 |
| abstract_inverted_index.Results | 169 |
| abstract_inverted_index.Society | 255 |
| abstract_inverted_index.adults. | 88 |
| abstract_inverted_index.average | 55 |
| abstract_inverted_index.between | 95 |
| abstract_inverted_index.centers | 81 |
| abstract_inverted_index.compare | 128 |
| abstract_inverted_index.diverse | 5 |
| abstract_inverted_index.examine | 122 |
| abstract_inverted_index.explore | 68 |
| abstract_inverted_index.follows | 253 |
| abstract_inverted_index.hormone | 11 |
| abstract_inverted_index.include | 260 |
| abstract_inverted_index.outcome | 160 |
| abstract_inverted_index.reasons | 31, 69, 141 |
| abstract_inverted_index.receipt | 15 |
| abstract_inverted_index.records | 149 |
| abstract_inverted_index.studies | 262 |
| abstract_inverted_index.therapy | 12, 52, 252 |
| abstract_inverted_index.years), | 211 |
| abstract_inverted_index.years). | 225 |
| abstract_inverted_index.(maximum | 59 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.academic | 80 |
| abstract_inverted_index.analyses | 118 |
| abstract_inverted_index.assigned | 135, 177, 185 |
| abstract_inverted_index.eligible | 172 |
| abstract_inverted_index.improved | 22 |
| abstract_inverted_index.included | 217 |
| abstract_inverted_index.measures | 161 |
| abstract_inverted_index.process. | 112 |
| abstract_inverted_index.research | 258 |
| abstract_inverted_index.stopping | 143 |
| abstract_inverted_index.survival | 117 |
| abstract_inverted_index.therapy. | 157 |
| abstract_inverted_index.uncommon | 250 |
| abstract_inverted_index.Endocrine | 254 |
| abstract_inverted_index.Objective | 36 |
| abstract_inverted_index.birthday, | 203 |
| abstract_inverted_index.estradiol | 92 |
| abstract_inverted_index.follow-up | 265 |
| abstract_inverted_index.incidence | 163 |
| abstract_inverted_index.included. | 104 |
| abstract_inverted_index.initiated | 197 |
| abstract_inverted_index.long-term | 264 |
| abstract_inverted_index.one-third | 191 |
| abstract_inverted_index.pediatric | 206 |
| abstract_inverted_index.providing | 82 |
| abstract_inverted_index.receiving | 268 |
| abstract_inverted_index.remaining | 214 |
| abstract_inverted_index.reviewing | 148 |
| abstract_inverted_index.Conclusion | 246 |
| abstract_inverted_index.associated | 20 |
| abstract_inverted_index.contacting | 152 |
| abstract_inverted_index.follow-up, | 235 |
| abstract_inverted_index.likelihood | 123 |
| abstract_inverted_index.prescribed | 91 |
| abstract_inverted_index.proportion | 46 |
| abstract_inverted_index.Transgender | 2 |
| abstract_inverted_index.adolescents | 86 |
| abstract_inverted_index.ascertained | 108 |
| abstract_inverted_index.discontinue | 51 |
| abstract_inverted_index.guidelines. | 256 |
| abstract_inverted_index.individuals | 7, 49, 90, 267 |
| abstract_inverted_index.initiation; | 64 |
| abstract_inverted_index.investigate | 44 |
| abstract_inverted_index.objectives: | 41 |
| abstract_inverted_index.permanently | 243 |
| abstract_inverted_index.prospective | 261 |
| abstract_inverted_index.well-being, | 23 |
| abstract_inverted_index.constituting | 204 |
| abstract_inverted_index.continuation | 106 |
| abstract_inverted_index.determinants | 165 |
| abstract_inverted_index.discontinued | 156, 232, 241 |
| abstract_inverted_index.investigated | 146 |
| abstract_inverted_index.participants | 154, 193, 230 |
| abstract_inverted_index.testosterone | 94 |
| abstract_inverted_index.participants, | 173 |
| abstract_inverted_index.retrospective | 76 |
| abstract_inverted_index.Kaplan–Meier | 116 |
| abstract_inverted_index.discontinuation | 28, 126, 129, 248 |
| abstract_inverted_index.discontinuation. | 72, 168 |
| abstract_inverted_index.gender-affirming | 10 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5058543746 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I150468666, https://openalex.org/I4210152539 |
| citation_normalized_percentile.value | 0.98608423 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |