Advanced biomimetic design strategies for porous structures promoting bone integration with additive-manufactured Ti6Al4V scaffolds Article Swipe
Yongyue Li
,
Qing Han
,
Hao Chen
,
Wenbo Yang
,
Yongjun Xu
,
Yongqi Zhang
,
Jiangbo Zhang
,
Li Liu
,
Weilong Zhang
,
Hao Liu
,
Bingpeng Chen
,
Jincheng Wang
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.jmrt.2024.08.040
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.jmrt.2024.08.040
The natural bone structure exhibits a radial gradient with dense cortical bone externally and porous cancellous bone internally. However, previous studies proposing scaffold designs have predominantly focused on homogeneous porous structures. Moreover, no consensus exists on the optimal structure for gradient porous scaffolds. Our scaffold closely imitated the natural bone structure by incorporating a gradient of pillar diameters. Additionally, we introduced a inverse gradient structure and three uniform diameter pillar structures (400 μm, 600 μm, and 1000 μm) for comparative analysis. Mechanical testing revealed that the compressive strength and elastic modulus of the Ti6Al4V porous scaffolds gradually increased with an increase in pillar diameter. In vitro experiments demonstrated that both the biomimetic gradient and inverse gradient scaffolds promoted osteogenic differentiation, with higher ALP activity (alkaline phosphatase) and osteogenesis-related gene expression compared to the uniform pillar structure scaffolds. The in vivo experiments confirmed these results, highlighting the superior ability of the biomimetic gradient Ti6Al4V porous scaffold to induce new bone formation. Based on our findings, we suggest that the optimal porous structure should have fine-diameter pillars (approximately 400 μm) internally to enhance cell penetration, while coarse-diameter pillars (approximately 800 μm) should be used externally to increase the cell attachment area and enhance mechanical strength. Overall, our study contributes to the field of bone tissue engineering by providing a biomimetic scaffold design that closely imitates the structure of natural bone and promotes osteogenic activity.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jmrt.2024.08.040
- OA Status
- gold
- Cited By
- 6
- References
- 74
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401486383
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4401486383Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.jmrt.2024.08.040Digital Object Identifier
- Title
-
Advanced biomimetic design strategies for porous structures promoting bone integration with additive-manufactured Ti6Al4V scaffoldsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-08-09Full publication date if available
- Authors
-
Yongyue Li, Qing Han, Hao Chen, Wenbo Yang, Yongjun Xu, Yongqi Zhang, Jiangbo Zhang, Li Liu, Weilong Zhang, Hao Liu, Bingpeng Chen, Jincheng WangList of authors in order
- Landing page
-
https://doi.org/10.1016/j.jmrt.2024.08.040Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1016/j.jmrt.2024.08.040Direct OA link when available
- Concepts
-
Materials science, Scaffold, Porosity, Cancellous bone, Compressive strength, Tissue engineering, Pillar, Elastic modulus, Biomedical engineering, Composite material, Nanotechnology, Structural engineering, Anatomy, Engineering, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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74Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.homogeneous | 28 |
| abstract_inverted_index.internally. | 17 |
| abstract_inverted_index.structures. | 30 |
| abstract_inverted_index.demonstrated | 107 |
| abstract_inverted_index.highlighting | 144 |
| abstract_inverted_index.penetration, | 182 |
| abstract_inverted_index.phosphatase) | 125 |
| abstract_inverted_index.Additionally, | 58 |
| abstract_inverted_index.fine-diameter | 173 |
| abstract_inverted_index.incorporating | 52 |
| abstract_inverted_index.predominantly | 25 |
| abstract_inverted_index.(approximately | 175, 186 |
| abstract_inverted_index.coarse-diameter | 184 |
| abstract_inverted_index.differentiation, | 119 |
| abstract_inverted_index.osteogenesis-related | 127 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5019204281 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I4210142484 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.41999998688697815 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.82016636 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |