Advancements in Research and Treatment Applications of Patient-Derived Tumor Organoids in Colorectal Cancer Article Swipe
Denise van der Graaff
,
Sofie Seghers
,
Pieterjan Vanclooster
,
Christophe Deben
,
Timon Vandamme
,
Hans Prenen
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/cancers16152671
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/cancers16152671
Colorectal cancer (CRC) remains a significant health burden globally, being the second leading cause of cancer-related mortality. Despite significant therapeutic advancements, resistance to systemic antineoplastic agents remains an important obstacle, highlighting the need for innovative screening tools to tailor patient-specific treatment. This review explores the application of patient-derived tumor organoids (PDTOs), three-dimensional, self-organizing models derived from patient tumor samples, as screening tools for drug resistance in CRC. PDTOs offer unique advantages over traditional models by recapitulating the tumor architecture, cellular heterogeneity, and genomic landscape and are a valuable ex vivo predictive drug screening tool. This review provides an overview of the current literature surrounding the use of PDTOs as an instrument for predicting therapy responses in CRC. We also explore more complex models, such as co-cultures with important stromal cells, such as cancer-associated fibroblasts, and organ-on-a-chip models. Furthermore, we discuss the use of PDTOs for drug repurposing, offering a new approach to identify the existing drugs effective against drug-resistant CRC. Additionally, we explore how PDTOs serve as models to gain insights into drug resistance mechanisms, using newer techniques, such as single-cell RNA sequencing and CRISPR-Cas9 genome editing. Through this review, we aim to highlight the potential of PDTOs in advancing our understanding of predicting therapy responses, drug resistance, and biomarker identification in CRC management.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers16152671
- OA Status
- gold
- Cited By
- 1
- References
- 105
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401014901Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/cancers16152671Digital Object Identifier
- Title
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Advancements in Research and Treatment Applications of Patient-Derived Tumor Organoids in Colorectal CancerWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-07-26Full publication date if available
- Authors
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Denise van der Graaff, Sofie Seghers, Pieterjan Vanclooster, Christophe Deben, Timon Vandamme, Hans PrenenList of authors in order
- Landing page
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https://doi.org/10.3390/cancers16152671Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3390/cancers16152671Direct OA link when available
- Concepts
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Colorectal cancer, Medicine, Repurposing, Drug repositioning, Precision medicine, CRISPR, Drug resistance, Personalized medicine, Cancer, Computational biology, Biomarker, Genome editing, Bioinformatics, Drug, Biology, Internal medicine, Pathology, Pharmacology, Ecology, Gene, Biochemistry, MicrobiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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