Advances and Recent Developments in Asthma in 2020 Article Swipe
Lacin Cevhertas
,
İsmail Öğülür
,
Debbie J. Maurer
,
Daniel Burla
,
Mei Ding
,
Kirstin Jansen
,
Jana Koch
,
Chengyao Liu
,
Siyuan Ma
,
Yasutaka Mitamura
,
Yaqi Peng
,
Urszula Radzikowska
,
Arturo Rinaldi
,
Pattraporn Satitsuksanoa
,
Anna Głobińska
,
Willem van de Veen
,
Milena Sokołowska
,
Katja Baerenfaller
,
Ya dong Gao
,
Ioana Agache
,
Mübeccel Akdiş
,
Cezmi A. Akdiş
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.22541/au.159837746.68999857
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.22541/au.159837746.68999857
In this review, we discuss recent publications on asthma and review the studies that have reported on the different aspects of the prevalence, risk factors and prevention, mechanisms, diagnosis and treatment of asthma. Many risk and protective factors and molecular mechanisms are involved in the development of asthma. Emerging concepts and challenges in implementing the exposome paradigm and its application in allergic diseases and asthma are reviewed, including genetic and epigenetic factors, microbial dysbiosis and environmental exposure, particularly to indoor and outdoor substances. The most relevant experimental studies further advancing the understanding of molecular and immune mechanisms with potential new targets for the development of therapeutics are discussed. A reliable diagnosis of asthma, disease endotyping and monitoring its severity are of great importance in the management of asthma. Correct evaluation and management of asthma comorbidity/multimorbidity, including interaction with asthma phenotypes and its value for the precision medicine approach and validation of predictive biomarkers are further detailed. Novel approaches and strategies in asthma treatment linked to mechanisms and endotypes of asthma, particularly biologicals, are critically appraised. Finally, due to the recent pandemics and its impact on patient management, we discuss the challenges, relationships, and molecular mechanisms between asthma, allergies, SARS-CoV-2 and Covid-19.
Related Topics
Concepts
Asthma
Medicine
Intensive care medicine
Exposome
Pandemic
Disease
Allergy
Comorbidity
Precision medicine
Asthma management
Immunology
Coronavirus disease 2019 (COVID-19)
Environmental health
Psychiatry
Infectious disease (medical specialty)
Pathology
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.22541/au.159837746.68999857
- https://journal.sketchingscience.org/doi/pdf/10.22541/au.159837746.68999857
- OA Status
- gold
- Cited By
- 2
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3080986586
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3080986586Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.22541/au.159837746.68999857Digital Object Identifier
- Title
-
Advances and Recent Developments in Asthma in 2020Work title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-08-25Full publication date if available
- Authors
-
Lacin Cevhertas, İsmail Öğülür, Debbie J. Maurer, Daniel Burla, Mei Ding, Kirstin Jansen, Jana Koch, Chengyao Liu, Siyuan Ma, Yasutaka Mitamura, Yaqi Peng, Urszula Radzikowska, Arturo Rinaldi, Pattraporn Satitsuksanoa, Anna Głobińska, Willem van de Veen, Milena Sokołowska, Katja Baerenfaller, Ya dong Gao, Ioana Agache, Mübeccel Akdiş, Cezmi A. AkdişList of authors in order
- Landing page
-
https://doi.org/10.22541/au.159837746.68999857Publisher landing page
- PDF URL
-
https://journal.sketchingscience.org/doi/pdf/10.22541/au.159837746.68999857Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journal.sketchingscience.org/doi/pdf/10.22541/au.159837746.68999857Direct OA link when available
- Concepts
-
Asthma, Medicine, Intensive care medicine, Exposome, Pandemic, Disease, Allergy, Comorbidity, Precision medicine, Asthma management, Immunology, Coronavirus disease 2019 (COVID-19), Environmental health, Psychiatry, Infectious disease (medical specialty), PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2021: 2Per-year citation counts (last 5 years)
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.diseases | 62 |
| abstract_inverted_index.exposome | 55 |
| abstract_inverted_index.factors, | 71 |
| abstract_inverted_index.involved | 42 |
| abstract_inverted_index.medicine | 146 |
| abstract_inverted_index.paradigm | 56 |
| abstract_inverted_index.relevant | 85 |
| abstract_inverted_index.reliable | 109 |
| abstract_inverted_index.reported | 15 |
| abstract_inverted_index.severity | 118 |
| abstract_inverted_index.Covid-19. | 200 |
| abstract_inverted_index.advancing | 89 |
| abstract_inverted_index.detailed. | 155 |
| abstract_inverted_index.diagnosis | 28, 110 |
| abstract_inverted_index.different | 18 |
| abstract_inverted_index.dysbiosis | 73 |
| abstract_inverted_index.endotypes | 167 |
| abstract_inverted_index.exposure, | 76 |
| abstract_inverted_index.including | 67, 135 |
| abstract_inverted_index.microbial | 72 |
| abstract_inverted_index.molecular | 39, 93, 193 |
| abstract_inverted_index.pandemics | 180 |
| abstract_inverted_index.potential | 98 |
| abstract_inverted_index.precision | 145 |
| abstract_inverted_index.reviewed, | 66 |
| abstract_inverted_index.treatment | 30, 162 |
| abstract_inverted_index.SARS-CoV-2 | 198 |
| abstract_inverted_index.allergies, | 197 |
| abstract_inverted_index.appraised. | 174 |
| abstract_inverted_index.approaches | 157 |
| abstract_inverted_index.biomarkers | 152 |
| abstract_inverted_index.challenges | 51 |
| abstract_inverted_index.critically | 173 |
| abstract_inverted_index.discussed. | 107 |
| abstract_inverted_index.endotyping | 114 |
| abstract_inverted_index.epigenetic | 70 |
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| abstract_inverted_index.importance | 122 |
| abstract_inverted_index.management | 125, 131 |
| abstract_inverted_index.mechanisms | 40, 96, 165, 194 |
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| abstract_inverted_index.phenotypes | 139 |
| abstract_inverted_index.predictive | 151 |
| abstract_inverted_index.protective | 36 |
| abstract_inverted_index.strategies | 159 |
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| abstract_inverted_index.application | 59 |
| abstract_inverted_index.challenges, | 190 |
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| abstract_inverted_index.management, | 186 |
| abstract_inverted_index.mechanisms, | 27 |
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| abstract_inverted_index.prevention, | 26 |
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| abstract_inverted_index.relationships, | 191 |
| abstract_inverted_index.comorbidity/multimorbidity, | 134 |
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| cited_by_percentile_year.min | 93 |
| countries_distinct_count | 5 |
| institutions_distinct_count | 22 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7900000214576721 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.56391742 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |