Advances in Spatial Multi‐Omics: A Review of Multi‐Modal Mass Spectrometry Imaging and Laser Capture Microdissection‐LCMS Integration Article Swipe
Jessica Lukowski
,
Byoung‐Kyu Cho
,
Antonia Zamacona Calderon
,
Borna Dianati
,
Katherine A. Stumpo
,
Savannah R. Snyder
,
Young Ah Goo
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/pmic.202400378
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/pmic.202400378
Mass spectrometry has long been utilized to characterize a variety of biomolecules such as proteins, metabolites, and lipids. Most MS‐based omics studies rely on bulk analysis; however, bulk approaches often overlook low‐abundance molecules that may exert critical biological effects. Recently, multi‐omics analyses have been driving an explosion of knowledge about how biomolecules interact within biological systems. In particular, spatial multi‐omics has emerged as a groundbreaking approach for implementing multi‐omic and multi‐modal analyses. Broadly defined, spatial omics has the ability to analyze biomolecules within their native spatial contexts, offering transformative insights. This review focuses on mass spectrometry‐based spatial omics, specifically matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI‐MSI). We will explore how MALDI‐MSI, in combination with laser capture microdissection (LCM) and traditional liquid chromatography‐mass spectrometry (LC‐MS) workflow, is advancing spatially resolved multi‐omics research.
Related Topics
Concepts
Mass spectrometry
Omics
Mass spectrometry imaging
Proteomics
Laser capture microdissection
Biomolecule
Computational biology
Workflow
MALDI imaging
Chemistry
Computer science
Bioinformatics
Matrix-assisted laser desorption/ionization
Biology
Chromatography
Biochemistry
Desorption
Adsorption
Database
Gene expression
Gene
Organic chemistry
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1002/pmic.202400378
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pmic.202400378
- OA Status
- bronze
- Cited By
- 3
- References
- 79
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410309993
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4410309993Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/pmic.202400378Digital Object Identifier
- Title
-
Advances in Spatial Multi‐Omics: A Review of Multi‐Modal Mass Spectrometry Imaging and Laser Capture Microdissection‐LCMS IntegrationWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-05-12Full publication date if available
- Authors
-
Jessica Lukowski, Byoung‐Kyu Cho, Antonia Zamacona Calderon, Borna Dianati, Katherine A. Stumpo, Savannah R. Snyder, Young Ah GooList of authors in order
- Landing page
-
https://doi.org/10.1002/pmic.202400378Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pmic.202400378Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pmic.202400378Direct OA link when available
- Concepts
-
Mass spectrometry, Omics, Mass spectrometry imaging, Proteomics, Laser capture microdissection, Biomolecule, Computational biology, Workflow, MALDI imaging, Chemistry, Computer science, Bioinformatics, Matrix-assisted laser desorption/ionization, Biology, Chromatography, Biochemistry, Desorption, Adsorption, Database, Gene expression, Gene, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3Per-year citation counts (last 5 years)
- References (count)
-
79Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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