Advances in the research of comorbid insomnia and depression: mechanisms, impacts, and interventions Article Swipe
Tao Gao
,
Han Xiang
,
Qian Wu
,
Ning Li
,
Wan Juan Pei
,
Weijie Fu
,
Tommy Chou
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fpsyt.2025.1468212
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fpsyt.2025.1468212
Insomnia and depression, both significantly impacting public health, are common psychosomatic illnesses that frequently co-occur in the same individual. Not only do these two conditions commonly co-occur, but they also exhibit a bidirectional link, where the existence of one may heighten the risk for the other. Latest research offers compelling evidence of significant overlap in biological, psychological, and sociological aspects in the comorbidity of insomnia and depression. Building on this, we aim to examine the pathophysiology of insomnia and depression, along with their comorbid mechanisms, encompassing biological routes (like genetics, HPA axis, immune-inflammatory activation, neuroendocrine regulation, microbiome alterations, and neural circuits integrating sleep and emotion regulation), as well as psychosocial routes. Consequently, proposing a self-perpetuating and mutually reinforcing “snowball effect” model of comorbid insomnia and depression, and examining corresponding preventative intervention strategies to rectify associated imbalances. Finally, this article encapsulates the challenges in this field of study and the directions for future research. Finally, the paper points out the limitations of current research (cross-sectional data being dominant, and the mechanism of multi-omics dynamics being unknown) and the future direction (longitudinal cohort combined with computational modeling to resolve temporal interactions), which will provide a theoretical basis for precision interventions.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fpsyt.2025.1468212
- https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1468212/pdf
- OA Status
- gold
- Cited By
- 5
- References
- 111
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408888266
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4408888266Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fpsyt.2025.1468212Digital Object Identifier
- Title
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Advances in the research of comorbid insomnia and depression: mechanisms, impacts, and interventionsWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-03-26Full publication date if available
- Authors
-
Tao Gao, Han Xiang, Qian Wu, Ning Li, Wan Juan Pei, Weijie Fu, Tommy ChouList of authors in order
- Landing page
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https://doi.org/10.3389/fpsyt.2025.1468212Publisher landing page
- PDF URL
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https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1468212/pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1468212/pdfDirect OA link when available
- Concepts
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Psychosocial, Psychological intervention, Insomnia, Psychology, Depression (economics), Comorbidity, Mechanism (biology), Intervention (counseling), Psychiatry, Clinical psychology, Medicine, Economics, Macroeconomics, Philosophy, EpistemologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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5Total citation count in OpenAlex
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2025: 5Per-year citation counts (last 5 years)
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111Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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