Affinity‐Controlled Partitioning of Biomolecules at Aqueous Interfaces and Their Bioanalytic Applications Article Swipe
Yang Cao
,
Youchuang Chao
,
Ho Cheung Shum
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/adma.202409362
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/adma.202409362
All‐aqueous phase separation systems play essential roles in bioanalytical and biochemical applications. Compared to conventional oil and organic solvent‐based systems, these systems are characterized by their rich bulk and interfacial properties, offering superior biocompatibility. In particular, phase separation in all‐aqueous systems facilitates the creation of compartments with specific physicochemical properties, and therefore largely enhances the accessibility of the systems. In addition, the all‐aqueous compartments have diverse affinities, with an important property known as partitioning, which can concentrate (bio)molecules toward distinct immiscible phases. This partitioning affinity imparts all‐aqueous interfaces with selective permeability, enabling the controlled enrichment of target (bio)molecules. This review introduces the basic principles and applications of partitioning‐induced interfacial phenomena in a typical all‐aqueous system, namely aqueous two‐phase systems (ATPSs); these applications include interfacial chemical reactions, bioprinting, and assembly, as well as bio‐sensing and detection. The primary challenges associated with designing all‐aqueous phase separation systems and several future directions are also discussed, such as the stabilization of aqueous interfaces, the handling of low‐volume samples, and exploration of suitable ATPSs compositions with the efficient protocol.
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Metadata
- Type
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- Language
- en
- Landing Page
- https://doi.org/10.1002/adma.202409362
- OA Status
- hybrid
- Cited By
- 11
- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4401747013Canonical identifier for this work in OpenAlex
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https://doi.org/10.1002/adma.202409362Digital Object Identifier
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Affinity‐Controlled Partitioning of Biomolecules at Aqueous Interfaces and Their Bioanalytic ApplicationsWork title
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reviewOpenAlex work type
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enPrimary language
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2024Year of publication
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2024-08-22Full publication date if available
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Yang Cao, Youchuang Chao, Ho Cheung ShumList of authors in order
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https://doi.org/10.1002/adma.202409362Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1002/adma.202409362Direct OA link when available
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Aqueous solution, Biomolecule, Materials science, Nanotechnology, Aqueous two-phase system, Molecule, Phase (matter), Biocompatibility, Chemical engineering, Chemistry, Organic chemistry, Metallurgy, EngineeringTop concepts (fields/topics) attached by OpenAlex
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11Total citation count in OpenAlex
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2025: 10, 2024: 1Per-year citation counts (last 5 years)
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160Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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