Age differences in spontaneous cerebrovascular reactivity at rest Article Swipe

PDF

Allison Engstrom , Shubir Dutt , John Paul M. Alitin , Arunima Kapoor , Trevor Lohman , Isabel J. Sible , Anisa Marshall , Fatemah Shenasa , Jillian L. Joyce , Aimée Gaubert , Farrah Ferrer , Amy Nguyen , Xingfeng Shao , Danny J.J. Wang , Daniel A. Nation ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1007/s11357-025-01935-9

Deficits in cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) may indicate vulnerability to vascular dysfunction and cognitive impairment. Prior findings on age-related change in CVR are mixed, and no studies to date have investigated age group differences in spontaneous CVR (sCVR) at rest. The present study compared whole brain and regional sCVR at rest between 24 healthy younger adults (ages 18–34) and 163 cognitively unimpaired older adults (ages 55–87). Relative to younger adults, older adults had deficits in both whole brain and regional sCVR at rest. Among the regions examined, medial temporal lobe areas showed the largest age differences in sCVR at rest. Age differences in sCVR and CBF variability were larger than age differences in mean CBF. Results show age-related deficits in sCVR are present even in cognitively unimpaired older adults, suggesting sCVR may be indicative of cerebrovascular aging. Further research should investigate sCVR as a means for early detection of age-related vascular dysfunction that may predate irreversible vascular brain injury.

Related Topics

Concepts

No concepts available.

Metadata

Type: article
Language: en
Landing Page: https://doi.org/10.1007/s11357-025-01935-9
PDF: https://link.springer.com/content/pdf/10.1007/s11357-025-01935-9.pdf
OA Status: hybrid
References: 44
OpenAlex ID: https://openalex.org/W4415693943

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4415693943

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1007/s11357-025-01935-9

Digital Object Identifier
Title: Age differences in spontaneous cerebrovascular reactivity at rest

Work title
Type: article

OpenAlex work type
Language: en

Primary language
Publication year: 2025

Year of publication
Publication date: 2025-10-30

Full publication date if available
Authors: Allison Engstrom, Shubir Dutt, John Paul M. Alitin, Arunima Kapoor, Trevor Lohman, Isabel J. Sible, Anisa Marshall, Fatemah Shenasa, Jillian L. Joyce, Aimée Gaubert, Farrah Ferrer, Amy Nguyen, Xingfeng Shao, Danny J.J. Wang, Daniel A. Nation

List of authors in order
Landing page: https://doi.org/10.1007/s11357-025-01935-9

Publisher landing page
PDF URL: https://link.springer.com/content/pdf/10.1007/s11357-025-01935-9.pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: hybrid

Open access status per OpenAlex
OA URL: https://link.springer.com/content/pdf/10.1007/s11357-025-01935-9.pdf

Direct OA link when available
Cited by: 0

Total citation count in OpenAlex
References (count): 44

Number of works referenced by this work

Full payload

id	https://openalex.org/W4415693943
doi	https://doi.org/10.1007/s11357-025-01935-9
ids.doi	https://doi.org/10.1007/s11357-025-01935-9
ids.pmid	https://pubmed.ncbi.nlm.nih.gov/41166037
ids.openalex	https://openalex.org/W4415693943
fwci	0.0
type	article
title	Age differences in spontaneous cerebrovascular reactivity at rest
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
is_xpac	False
apc_list.value	3090
apc_list.currency	EUR
apc_list.value_usd	3990
apc_paid.value	3090
apc_paid.currency	EUR
apc_paid.value_usd	3990
language	en
locations[0].id	doi:10.1007/s11357-025-01935-9
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S4210237251
locations[0].source.issn	2509-2715, 2509-2723
locations[0].source.type	journal
locations[0].source.is_oa	False
locations[0].source.issn_l	2509-2715
locations[0].source.is_core	True
locations[0].source.is_in_doaj	False
locations[0].source.display_name	GeroScience
locations[0].source.host_organization	https://openalex.org/P4310319972
locations[0].source.host_organization_name	Springer International Publishing
locations[0].source.host_organization_lineage	https://openalex.org/P4310319972
locations[0].license	cc-by
locations[0].pdf_url	https://link.springer.com/content/pdf/10.1007/s11357-025-01935-9.pdf
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	GeroScience
locations[0].landing_page_url	https://doi.org/10.1007/s11357-025-01935-9
locations[1].id	pmid:41166037
locations[1].is_oa	False
locations[1].source.id	https://openalex.org/S4306525036
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	PubMed
locations[1].source.host_organization	https://openalex.org/I1299303238
locations[1].source.host_organization_name	National Institutes of Health
locations[1].source.host_organization_lineage	https://openalex.org/I1299303238
locations[1].license
locations[1].pdf_url
locations[1].version	publishedVersion
locations[1].raw_type
locations[1].license_id
locations[1].is_accepted	True
locations[1].is_published	True
locations[1].raw_source_name	GeroScience
locations[1].landing_page_url	https://pubmed.ncbi.nlm.nih.gov/41166037
indexed_in	crossref, pubmed
authorships[0].author.id	https://openalex.org/A5102707058
authorships[0].author.orcid	https://orcid.org/0000-0002-9211-8115
authorships[0].author.display_name	Allison Engstrom
authorships[0].countries	US
authorships[0].affiliations[0].institution_ids	https://openalex.org/I204250578
authorships[0].affiliations[0].raw_affiliation_string	Department of Psychological Science, Social and Behavioral Sciences Gateway, University of California, Irvine, 4201, Irvine, CA, 92697-7085, USA
authorships[0].institutions[0].id	https://openalex.org/I204250578
authorships[0].institutions[0].ror	https://ror.org/04gyf1771
authorships[0].institutions[0].type	education
authorships[0].institutions[0].lineage	https://openalex.org/I204250578
authorships[0].institutions[0].country_code	US
authorships[0].institutions[0].display_name	University of California, Irvine
authorships[0].author_position	first
authorships[0].raw_author_name	Allison C. Engstrom
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	Department of Psychological Science, Social and Behavioral Sciences Gateway, University of California, Irvine, 4201, Irvine, CA, 92697-7085, USA
authorships[1].author.id	https://openalex.org/A5027759356
authorships[1].author.orcid	https://orcid.org/0000-0002-8408-2220
authorships[1].author.display_name	Shubir Dutt
authorships[1].countries	US
authorships[1].affiliations[0].institution_ids	https://openalex.org/I180670191, https://openalex.org/I4210105208
authorships[1].affiliations[0].raw_affiliation_string	Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, 1651 4Th St Suite 212, San Francisco, CA, 94158, USA
authorships[1].institutions[0].id	https://openalex.org/I4210105208
authorships[1].institutions[0].ror	https://ror.org/01dssfj41
authorships[1].institutions[0].type	education
authorships[1].institutions[0].lineage	https://openalex.org/I4210105208
authorships[1].institutions[0].country_code	US
authorships[1].institutions[0].display_name	University Memory and Aging Center
authorships[1].institutions[1].id	https://openalex.org/I180670191
authorships[1].institutions[1].ror	https://ror.org/043mz5j54
authorships[1].institutions[1].type	education
authorships[1].institutions[1].lineage	https://openalex.org/I180670191
authorships[1].institutions[1].country_code	US
authorships[1].institutions[1].display_name	University of California, San Francisco
authorships[1].author_position	middle
authorships[1].raw_author_name	Shubir Dutt
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, 1651 4Th St Suite 212, San Francisco, CA, 94158, USA
authorships[2].author.id	https://openalex.org/A5066170443
authorships[2].author.orcid	https://orcid.org/0009-0001-5494-9639
authorships[2].author.display_name	John Paul M. Alitin
authorships[2].countries	US
authorships[2].affiliations[0].institution_ids	https://openalex.org/I1174212
authorships[2].affiliations[0].raw_affiliation_string	Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA
authorships[2].institutions[0].id	https://openalex.org/I1174212
authorships[2].institutions[0].ror	https://ror.org/03taz7m60
authorships[2].institutions[0].type	education
authorships[2].institutions[0].lineage	https://openalex.org/I1174212
authorships[2].institutions[0].country_code	US
authorships[2].institutions[0].display_name	University of Southern California
authorships[2].author_position	middle
authorships[2].raw_author_name	John Paul M. Alitin
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA
authorships[3].author.id	https://openalex.org/A5084394843
authorships[3].author.orcid	https://orcid.org/0000-0003-4622-8951
authorships[3].author.display_name	Arunima Kapoor
authorships[3].countries	US
authorships[3].affiliations[0].institution_ids	https://openalex.org/I204250578
authorships[3].affiliations[0].raw_affiliation_string	Department of Psychological Science, Social and Behavioral Sciences Gateway, University of California, Irvine, 4201, Irvine, CA, 92697-7085, USA
authorships[3].institutions[0].id	https://openalex.org/I204250578
authorships[3].institutions[0].ror	https://ror.org/04gyf1771
authorships[3].institutions[0].type	education
authorships[3].institutions[0].lineage	https://openalex.org/I204250578
authorships[3].institutions[0].country_code	US
authorships[3].institutions[0].display_name	University of California, Irvine
authorships[3].author_position	middle
authorships[3].raw_author_name	Arunima Kapoor
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	Department of Psychological Science, Social and Behavioral Sciences Gateway, University of California, Irvine, 4201, Irvine, CA, 92697-7085, USA
authorships[4].author.id	https://openalex.org/A5059062734
authorships[4].author.orcid	https://orcid.org/0000-0002-9634-702X
authorships[4].author.display_name	Trevor Lohman
authorships[4].countries	US
authorships[4].affiliations[0].institution_ids	https://openalex.org/I180670191, https://openalex.org/I4210105208
authorships[4].affiliations[0].raw_affiliation_string	Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, 1651 4Th St Suite 212, San Francisco, CA, 94158, USA
authorships[4].institutions[0].id	https://openalex.org/I4210105208
authorships[4].institutions[0].ror	https://ror.org/01dssfj41
authorships[4].institutions[0].type	education
authorships[4].institutions[0].lineage	https://openalex.org/I4210105208
authorships[4].institutions[0].country_code	US
authorships[4].institutions[0].display_name	University Memory and Aging Center
authorships[4].institutions[1].id	https://openalex.org/I180670191
authorships[4].institutions[1].ror	https://ror.org/043mz5j54
authorships[4].institutions[1].type	education
authorships[4].institutions[1].lineage	https://openalex.org/I180670191
authorships[4].institutions[1].country_code	US
authorships[4].institutions[1].display_name	University of California, San Francisco
authorships[4].author_position	middle
authorships[4].raw_author_name	Trevor Lohman
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, 1651 4Th St Suite 212, San Francisco, CA, 94158, USA
authorships[5].author.id	https://openalex.org/A5084736757
authorships[5].author.orcid	https://orcid.org/0000-0003-3922-0628
authorships[5].author.display_name	Isabel J. Sible
authorships[5].countries	US
authorships[5].affiliations[0].institution_ids	https://openalex.org/I1174212
authorships[5].affiliations[0].raw_affiliation_string	Department of Psychology, G. Mudd Building, University of Southern California, 3620 McClintock Ave, Los Angeles, CA, 90089, USA
authorships[5].institutions[0].id	https://openalex.org/I1174212
authorships[5].institutions[0].ror	https://ror.org/03taz7m60
authorships[5].institutions[0].type	education
authorships[5].institutions[0].lineage	https://openalex.org/I1174212
authorships[5].institutions[0].country_code	US
authorships[5].institutions[0].display_name	University of Southern California
authorships[5].author_position	middle
authorships[5].raw_author_name	Isabel J. Sible
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	Department of Psychology, G. Mudd Building, University of Southern California, 3620 McClintock Ave, Los Angeles, CA, 90089, USA
authorships[6].author.id	https://openalex.org/A5102910346
authorships[6].author.orcid	https://orcid.org/0000-0001-5457-2520
authorships[6].author.display_name	Anisa Marshall
authorships[6].countries	US
authorships[6].affiliations[0].institution_ids	https://openalex.org/I1174212
authorships[6].affiliations[0].raw_affiliation_string	Department of Psychology, G. Mudd Building, University of Southern California, 3620 McClintock Ave, Los Angeles, CA, 90089, USA
authorships[6].institutions[0].id	https://openalex.org/I1174212
authorships[6].institutions[0].ror	https://ror.org/03taz7m60
authorships[6].institutions[0].type	education
authorships[6].institutions[0].lineage	https://openalex.org/I1174212
authorships[6].institutions[0].country_code	US
authorships[6].institutions[0].display_name	University of Southern California
authorships[6].author_position	middle
authorships[6].raw_author_name	Anisa J. Marshall
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	Department of Psychology, G. Mudd Building, University of Southern California, 3620 McClintock Ave, Los Angeles, CA, 90089, USA
authorships[7].author.id	https://openalex.org/A5024683717
authorships[7].author.orcid	https://orcid.org/0000-0001-9030-4857
authorships[7].author.display_name	Fatemah Shenasa
authorships[7].countries	US
authorships[7].affiliations[0].institution_ids	https://openalex.org/I204250578
authorships[7].affiliations[0].raw_affiliation_string	Department of Psychological Science, Social and Behavioral Sciences Gateway, University of California, Irvine, 4201, Irvine, CA, 92697-7085, USA
authorships[7].institutions[0].id	https://openalex.org/I204250578
authorships[7].institutions[0].ror	https://ror.org/04gyf1771
authorships[7].institutions[0].type	education
authorships[7].institutions[0].lineage	https://openalex.org/I204250578
authorships[7].institutions[0].country_code	US
authorships[7].institutions[0].display_name	University of California, Irvine
authorships[7].author_position	middle
authorships[7].raw_author_name	Fatemah Shenasa
authorships[7].is_corresponding	False
authorships[7].raw_affiliation_strings	Department of Psychological Science, Social and Behavioral Sciences Gateway, University of California, Irvine, 4201, Irvine, CA, 92697-7085, USA
authorships[8].author.id	https://openalex.org/A5043857179
authorships[8].author.orcid	https://orcid.org/0000-0001-5311-4798
authorships[8].author.display_name	Jillian L. Joyce
authorships[8].countries	US
authorships[8].affiliations[0].institution_ids	https://openalex.org/I1174212
authorships[8].affiliations[0].raw_affiliation_string	Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA
authorships[8].institutions[0].id	https://openalex.org/I1174212
authorships[8].institutions[0].ror	https://ror.org/03taz7m60
authorships[8].institutions[0].type	education
authorships[8].institutions[0].lineage	https://openalex.org/I1174212
authorships[8].institutions[0].country_code	US
authorships[8].institutions[0].display_name	University of Southern California
authorships[8].author_position	middle
authorships[8].raw_author_name	Jillian L. Joyce
authorships[8].is_corresponding	False
authorships[8].raw_affiliation_strings	Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA
authorships[9].author.id	https://openalex.org/A5085349073
authorships[9].author.orcid	https://orcid.org/0000-0001-6812-522X
authorships[9].author.display_name	Aimée Gaubert
authorships[9].countries	US
authorships[9].affiliations[0].institution_ids	https://openalex.org/I1174212
authorships[9].affiliations[0].raw_affiliation_string	Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA
authorships[9].institutions[0].id	https://openalex.org/I1174212
authorships[9].institutions[0].ror	https://ror.org/03taz7m60
authorships[9].institutions[0].type	education
authorships[9].institutions[0].lineage	https://openalex.org/I1174212
authorships[9].institutions[0].country_code	US
authorships[9].institutions[0].display_name	University of Southern California
authorships[9].author_position	middle
authorships[9].raw_author_name	Aimée Gaubert
authorships[9].is_corresponding	False
authorships[9].raw_affiliation_strings	Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA
authorships[10].author.id	https://openalex.org/A5091021055
authorships[10].author.orcid	https://orcid.org/0009-0003-7301-0680
authorships[10].author.display_name	Farrah Ferrer
authorships[10].countries	US
authorships[10].affiliations[0].institution_ids	https://openalex.org/I1174212
authorships[10].affiliations[0].raw_affiliation_string	Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA
authorships[10].institutions[0].id	https://openalex.org/I1174212
authorships[10].institutions[0].ror	https://ror.org/03taz7m60
authorships[10].institutions[0].type	education
authorships[10].institutions[0].lineage	https://openalex.org/I1174212
authorships[10].institutions[0].country_code	US
authorships[10].institutions[0].display_name	University of Southern California
authorships[10].author_position	middle
authorships[10].raw_author_name	Farrah Ferrer
authorships[10].is_corresponding	False
authorships[10].raw_affiliation_strings	Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA
authorships[11].author.id	https://openalex.org/A5081517451
authorships[11].author.orcid	https://orcid.org/0000-0002-5939-9306
authorships[11].author.display_name	Amy Nguyen
authorships[11].countries	US
authorships[11].affiliations[0].institution_ids	https://openalex.org/I1174212
authorships[11].affiliations[0].raw_affiliation_string	Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA
authorships[11].institutions[0].id	https://openalex.org/I1174212
authorships[11].institutions[0].ror	https://ror.org/03taz7m60
authorships[11].institutions[0].type	education
authorships[11].institutions[0].lineage	https://openalex.org/I1174212
authorships[11].institutions[0].country_code	US
authorships[11].institutions[0].display_name	University of Southern California
authorships[11].author_position	middle
authorships[11].raw_author_name	Amy Nguyen
authorships[11].is_corresponding	False
authorships[11].raw_affiliation_strings	Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA
authorships[12].author.id	https://openalex.org/A5040892686
authorships[12].author.orcid	https://orcid.org/0000-0002-4130-6204
authorships[12].author.display_name	Xingfeng Shao
authorships[12].countries	US
authorships[12].affiliations[0].institution_ids	https://openalex.org/I1174212
authorships[12].affiliations[0].raw_affiliation_string	Stevens Neuroimaging and Informatics Institute, University of Southern California, 2025 Zonal Ave, Los Angeles, CA, 90033, USA
authorships[12].institutions[0].id	https://openalex.org/I1174212
authorships[12].institutions[0].ror	https://ror.org/03taz7m60
authorships[12].institutions[0].type	education
authorships[12].institutions[0].lineage	https://openalex.org/I1174212
authorships[12].institutions[0].country_code	US
authorships[12].institutions[0].display_name	University of Southern California
authorships[12].author_position	middle
authorships[12].raw_author_name	Xingfeng Shao
authorships[12].is_corresponding	False
authorships[12].raw_affiliation_strings	Stevens Neuroimaging and Informatics Institute, University of Southern California, 2025 Zonal Ave, Los Angeles, CA, 90033, USA
authorships[13].author.id	https://openalex.org/A5066687350
authorships[13].author.orcid	https://orcid.org/0000-0002-0840-7062
authorships[13].author.display_name	Danny J.J. Wang
authorships[13].countries	US
authorships[13].affiliations[0].institution_ids	https://openalex.org/I1174212
authorships[13].affiliations[0].raw_affiliation_string	Stevens Neuroimaging and Informatics Institute, University of Southern California, 2025 Zonal Ave, Los Angeles, CA, 90033, USA
authorships[13].institutions[0].id	https://openalex.org/I1174212
authorships[13].institutions[0].ror	https://ror.org/03taz7m60
authorships[13].institutions[0].type	education
authorships[13].institutions[0].lineage	https://openalex.org/I1174212
authorships[13].institutions[0].country_code	US
authorships[13].institutions[0].display_name	University of Southern California
authorships[13].author_position	middle
authorships[13].raw_author_name	Danny J. J. Wang
authorships[13].is_corresponding	False
authorships[13].raw_affiliation_strings	Stevens Neuroimaging and Informatics Institute, University of Southern California, 2025 Zonal Ave, Los Angeles, CA, 90033, USA
authorships[14].author.id	https://openalex.org/A5020498061
authorships[14].author.orcid	https://orcid.org/0000-0002-9123-0658
authorships[14].author.display_name	Daniel A. Nation
authorships[14].countries	US
authorships[14].affiliations[0].institution_ids	https://openalex.org/I1174212
authorships[14].affiliations[0].raw_affiliation_string	Keck School of Medicine, University of Southern California, 1975 Zonal Ave., Los Angeles, CA, 90033, USA
authorships[14].institutions[0].id	https://openalex.org/I1174212
authorships[14].institutions[0].ror	https://ror.org/03taz7m60
authorships[14].institutions[0].type	education
authorships[14].institutions[0].lineage	https://openalex.org/I1174212
authorships[14].institutions[0].country_code	US
authorships[14].institutions[0].display_name	University of Southern California
authorships[14].author_position	last
authorships[14].raw_author_name	Daniel A. Nation
authorships[14].is_corresponding	True
authorships[14].raw_affiliation_strings	Keck School of Medicine, University of Southern California, 1975 Zonal Ave., Los Angeles, CA, 90033, USA
has_content.pdf	True
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://link.springer.com/content/pdf/10.1007/s11357-025-01935-9.pdf
open_access.oa_status	hybrid
open_access.any_repository_has_fulltext	False
created_date	2025-10-30T00:00:00
display_name	Age differences in spontaneous cerebrovascular reactivity at rest
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic
cited_by_count	0
locations_count	2
best_oa_location.id	doi:10.1007/s11357-025-01935-9
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S4210237251
best_oa_location.source.issn	2509-2715, 2509-2723
best_oa_location.source.type	journal
best_oa_location.source.is_oa	False
best_oa_location.source.issn_l	2509-2715
best_oa_location.source.is_core	True
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	GeroScience
best_oa_location.source.host_organization	https://openalex.org/P4310319972
best_oa_location.source.host_organization_name	Springer International Publishing
best_oa_location.source.host_organization_lineage	https://openalex.org/P4310319972
best_oa_location.license	cc-by
best_oa_location.pdf_url	https://link.springer.com/content/pdf/10.1007/s11357-025-01935-9.pdf
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	GeroScience
best_oa_location.landing_page_url	https://doi.org/10.1007/s11357-025-01935-9
primary_location.id	doi:10.1007/s11357-025-01935-9
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S4210237251
primary_location.source.issn	2509-2715, 2509-2723
primary_location.source.type	journal
primary_location.source.is_oa	False
primary_location.source.issn_l	2509-2715
primary_location.source.is_core	True
primary_location.source.is_in_doaj	False
primary_location.source.display_name	GeroScience
primary_location.source.host_organization	https://openalex.org/P4310319972
primary_location.source.host_organization_name	Springer International Publishing
primary_location.source.host_organization_lineage	https://openalex.org/P4310319972
primary_location.license	cc-by
primary_location.pdf_url	https://link.springer.com/content/pdf/10.1007/s11357-025-01935-9.pdf
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	GeroScience
primary_location.landing_page_url	https://doi.org/10.1007/s11357-025-01935-9
publication_date	2025-10-30
publication_year	2025
referenced_works	https://openalex.org/W2427948242, https://openalex.org/W3135999362, https://openalex.org/W2911147760, https://openalex.org/W3041164494, https://openalex.org/W2910508414, https://openalex.org/W2623854426, https://openalex.org/W3091838285, https://openalex.org/W4404474412, https://openalex.org/W2789964425, https://openalex.org/W4406202685, https://openalex.org/W2764295685, https://openalex.org/W2793407983, https://openalex.org/W2944301239, https://openalex.org/W2058709849, https://openalex.org/W3134338907, https://openalex.org/W2949139184, https://openalex.org/W3125549778, https://openalex.org/W2027085222, https://openalex.org/W2060618901, https://openalex.org/W2821792225, https://openalex.org/W2980826976, https://openalex.org/W2945272841, https://openalex.org/W4213200130, https://openalex.org/W2747107819, https://openalex.org/W4294300834, https://openalex.org/W2913346996, https://openalex.org/W1526060982, https://openalex.org/W2007543006, https://openalex.org/W2007734075, https://openalex.org/W1808254979, https://openalex.org/W3014928527, https://openalex.org/W2809090838, https://openalex.org/W1972685664, https://openalex.org/W2050096761, https://openalex.org/W4308620305, https://openalex.org/W2557712647, https://openalex.org/W2973007151, https://openalex.org/W2111464173, https://openalex.org/W1589310095, https://openalex.org/W2051159072, https://openalex.org/W2951144892, https://openalex.org/W4391845341, https://openalex.org/W2161244114, https://openalex.org/W4399518886
referenced_works_count	44
abstract_inverted_index.a	148
abstract_inverted_index.24	57
abstract_inverted_index.as	147
abstract_inverted_index.at	43, 54, 86, 103
abstract_inverted_index.be	137
abstract_inverted_index.in	2, 25, 39, 79, 101, 107, 117, 124, 129
abstract_inverted_index.no	30
abstract_inverted_index.of	139, 153
abstract_inverted_index.on	22
abstract_inverted_index.to	14, 32, 72
abstract_inverted_index.163	64
abstract_inverted_index.Age	105
abstract_inverted_index.CBF	110
abstract_inverted_index.CVR	26, 41
abstract_inverted_index.The	45
abstract_inverted_index.age	36, 99, 115
abstract_inverted_index.and	7, 17, 29, 51, 63, 83, 109
abstract_inverted_index.are	27, 126
abstract_inverted_index.for	150
abstract_inverted_index.had	77
abstract_inverted_index.may	11, 136, 158
abstract_inverted_index.the	89, 97
abstract_inverted_index.CBF.	119
abstract_inverted_index.both	80
abstract_inverted_index.date	33
abstract_inverted_index.even	128
abstract_inverted_index.flow	5
abstract_inverted_index.have	34
abstract_inverted_index.lobe	94
abstract_inverted_index.mean	118
abstract_inverted_index.rest	55
abstract_inverted_index.sCVR	53, 85, 102, 108, 125, 135, 146
abstract_inverted_index.show	121
abstract_inverted_index.than	114
abstract_inverted_index.that	157
abstract_inverted_index.were	112
abstract_inverted_index.(CBF)	6
abstract_inverted_index.(CVR)	10
abstract_inverted_index.(ages	61, 69
abstract_inverted_index.Among	88
abstract_inverted_index.Prior	20
abstract_inverted_index.areas	95
abstract_inverted_index.blood	4
abstract_inverted_index.brain	50, 82, 162
abstract_inverted_index.early	151
abstract_inverted_index.group	37
abstract_inverted_index.means	149
abstract_inverted_index.older	67, 75, 132
abstract_inverted_index.rest.	44, 87, 104
abstract_inverted_index.study	47
abstract_inverted_index.whole	49, 81
abstract_inverted_index.(sCVR)	42
abstract_inverted_index.adults	60, 68, 76
abstract_inverted_index.aging.	141
abstract_inverted_index.change	24
abstract_inverted_index.larger	113
abstract_inverted_index.medial	92
abstract_inverted_index.mixed,	28
abstract_inverted_index.should	144
abstract_inverted_index.showed	96
abstract_inverted_index.Further	142
abstract_inverted_index.Results	120
abstract_inverted_index.adults,	74, 133
abstract_inverted_index.between	56
abstract_inverted_index.healthy	58
abstract_inverted_index.injury.	163
abstract_inverted_index.largest	98
abstract_inverted_index.predate	159
abstract_inverted_index.present	46, 127
abstract_inverted_index.regions	90
abstract_inverted_index.studies	31
abstract_inverted_index.younger	59, 73
abstract_inverted_index.18–34)	62
abstract_inverted_index.Abstract	0
abstract_inverted_index.Deficits	1
abstract_inverted_index.Relative	71
abstract_inverted_index.cerebral	3
abstract_inverted_index.compared	48
abstract_inverted_index.deficits	78, 123
abstract_inverted_index.findings	21
abstract_inverted_index.indicate	12
abstract_inverted_index.regional	52, 84
abstract_inverted_index.research	143
abstract_inverted_index.temporal	93
abstract_inverted_index.vascular	15, 155, 161
abstract_inverted_index.55–87).	70
abstract_inverted_index.cognitive	18
abstract_inverted_index.detection	152
abstract_inverted_index.examined,	91
abstract_inverted_index.indicative	138
abstract_inverted_index.reactivity	9
abstract_inverted_index.suggesting	134
abstract_inverted_index.unimpaired	66, 131
abstract_inverted_index.age-related	23, 122, 154
abstract_inverted_index.cognitively	65, 130
abstract_inverted_index.differences	38, 100, 106, 116
abstract_inverted_index.dysfunction	16, 156
abstract_inverted_index.impairment.	19
abstract_inverted_index.investigate	145
abstract_inverted_index.spontaneous	40
abstract_inverted_index.variability	111
abstract_inverted_index.investigated	35
abstract_inverted_index.irreversible	160
abstract_inverted_index.vulnerability	13
abstract_inverted_index.cerebrovascular	8, 140
cited_by_percentile_year
corresponding_author_ids	https://openalex.org/A5020498061
countries_distinct_count	1
institutions_distinct_count	15
corresponding_institution_ids	https://openalex.org/I1174212
citation_normalized_percentile