Age-related changes in layer II immature neurons of the murine piriform cortex Article Swipe
Marco Ghibaudi
,
Nicole Marchetti
,
Elena Vergnano
,
Chiara La Rosa
,
Bruno Benedetti
,
Sébastien Couillard‐Després
,
Stefano Farioli‐Vecchioli
,
Luca Bonfanti
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fncel.2023.1205173
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fncel.2023.1205173
The recent identification of a population of non-newly born, prenatally generated “immature” neurons in the layer II of the piriform cortex (cortical immature neurons, cINs), raises questions concerning their maintenance or depletion through the lifespan. Most forms of brain structural plasticity progressively decline with age, a feature that is particularly prominent in adult neurogenesis, due to stem cell depletion. By contrast, the entire population of the cINs is produced during embryogenesis. Then these cells simply retain immaturity in postnatal and adult stages, until they “awake” to complete their maturation and ultimately integrate into neural circuits. Hence, the question remains open whether the cINs, which are not dependent on stem cell division, might follow a similar pattern of age-related reduction, or in alternative, might leave a reservoir of young, undifferentiated cells in the adult and aging brain. Here, the number and features of cINs were analyzed in the mouse piriform cortex from postnatal to advanced ages, by using immunocytochemistry for the cytoskeletal marker doublecortin. The abundance and stage of maturation of cINs, along with the expression of other markers of maturity/immaturity were investigated. Despite a marked decrease in this neuronal population during juvenile stages, reminiscent of that observed in hippocampal neurogenesis, a small amount of highly immature cINs persisted up to advanced ages. Overall, albeit reducing in number with increasing age, we report that the cINs are present through the entire animal lifespan.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fncel.2023.1205173
- https://www.frontiersin.org/articles/10.3389/fncel.2023.1205173/pdf
- OA Status
- gold
- Cited By
- 12
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4385342824
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4385342824Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fncel.2023.1205173Digital Object Identifier
- Title
-
Age-related changes in layer II immature neurons of the murine piriform cortexWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-07-28Full publication date if available
- Authors
-
Marco Ghibaudi, Nicole Marchetti, Elena Vergnano, Chiara La Rosa, Bruno Benedetti, Sébastien Couillard‐Després, Stefano Farioli‐Vecchioli, Luca BonfantiList of authors in order
- Landing page
-
https://doi.org/10.3389/fncel.2023.1205173Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fncel.2023.1205173/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/articles/10.3389/fncel.2023.1205173/pdfDirect OA link when available
- Concepts
-
Piriform cortex, Neurogenesis, Doublecortin, Biology, Hippocampal formation, Neuroscience, Population, Immunocytochemistry, Neural stem cell, Cortex (anatomy), Neuroplasticity, Stem cell, Hippocampus, Cell biology, Endocrinology, Dentate gyrus, Medicine, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
12Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 4, 2023: 3Per-year citation counts (last 5 years)
- References (count)
-
61Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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