Aging Cell • Vol 22 • No 4
Age‐related changes to adipose tissue and peripheral neuropathy in genetically diverse <scp>HET3</scp> mice differ by sex and are not mitigated by rapamycin longevity treatment
February 2023 • Jake W. Willows, Morganne Robinson, Zahra Alshahal, Samantha K. Morrison, Gargi Mishra, Harrison Cyr, Magdalena Blaszkiewicz, Gilian Gunsch, Sabrina …
Abstract Neural communication between the brain and adipose tissues regulates energy expenditure and metabolism through modulation of adipose tissue functions. We have recently demonstrated that under pathophysiological conditions (obesity, diabetes, and aging), total subcutaneous white adipose tissue (scWAT) innervation is decreased (‘adipose neuropathy’). With advanced age in the C57BL/6J mouse, small fiber peripheral nerve endings in adipose tissue die back, resulting in reduced contact with adipose‐resident bl…