Aggressive Serous Carcinomas of the Female Reproductive Tract: Cancer-Prone Cell States and Genetic Drivers Article Swipe
Daryl J. Phuong
,
Matalin G. Pirtz
,
Coulter Q. Ralston
,
Benjamin D. Cosgrove
,
John C. Schimenti
,
Andrea Flesken‐Nikitin
,
Alexander Yu. Nikitin
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/cancers17040604
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/cancers17040604
In 2025, gynecological cancers are projected to account for approximately 10% of cancer-related deaths in women. High-grade serous ovarian carcinoma (HGSC) and serous endometrial carcinoma (SEC) are the most lethal gynecological cancer subtypes. Both malignancies commonly have TP53 mutations, alterations of the RB1 pathway, and numerous secondary mutations. Both carcinoma types consist of poorly differentiated and highly heterogeneous cell populations at the time of detection. Latent development and rapid progression of HGSC and SEC impede the identification of definitive cells of origin and genetic drivers. Here, we review our current knowledge about cancer-prone cell states and genetic drivers. We also discuss how emerging transcriptomic and genetic tools applied to contemporary model systems may facilitate the identification of novel targets for timely detection and therapeutic intervention.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers17040604
- OA Status
- gold
- Cited By
- 2
- References
- 109
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407410775
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4407410775Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/cancers17040604Digital Object Identifier
- Title
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Aggressive Serous Carcinomas of the Female Reproductive Tract: Cancer-Prone Cell States and Genetic DriversWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-02-11Full publication date if available
- Authors
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Daryl J. Phuong, Matalin G. Pirtz, Coulter Q. Ralston, Benjamin D. Cosgrove, John C. Schimenti, Andrea Flesken‐Nikitin, Alexander Yu. NikitinList of authors in order
- Landing page
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https://doi.org/10.3390/cancers17040604Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3390/cancers17040604Direct OA link when available
- Concepts
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Serous carcinoma, Serous fluid, Cancer, Ovarian cancer, Transcriptome, Endometrial cancer, Clear cell carcinoma, Biology, Medicine, Identification (biology), Carcinoma, Cancer research, Bioinformatics, Oncology, Gene, Pathology, Internal medicine, Genetics, Botany, Gene expressionTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2Per-year citation counts (last 5 years)
- References (count)
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109Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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