Airway stenosis: classification, pathogenesis, and clinical management Article Swipe
YOU?
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· 2025
· Open Access
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· DOI: https://doi.org/10.1002/mco2.70076
Airway stenosis (AS) is a fibroinflammatory disease characterized by abnormal activation of fibroblasts and excessive synthesis of extracellular matrix, which has puzzled many doctors despite its relatively low prevalence. Traditional treatment such as endoscopic surgery, open surgery, and adjuvant therapy have many disadvantages and are limited in the treatment of patients with recurrent AS. Therefore, it is urgent to reveal the pathogenesis of AS and accelerate its clinical transformation. Based on the discovered pathogenesis, including fibrosis, inflammation, epithelial–mesenchymal transition, metabolic reprogramming, microbiome, genetic susceptibility, and other mechanisms, researchers have developed a series of treatments, such as drug therapy, gene therapy, stem cell therapy, growth factor therapy, protein therapy, and photodynamic therapy. This review introduces the classification of AS, explores the existing pathogenesis and preclinical treatments developed based on the pathogenesis, and finally summarizes the current clinical management. In addition, the prospect of exploring the interaction between different types of cells and between microorganisms and cells to identify the intersection of multiple mechanisms based on single‐cell RNA sequencing, 16S rRNA gene sequencing and shotgun metagenomic sequencing is worth looking forward to.
Related Topics
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1002/mco2.70076
- OA Status
- gold
- Cited By
- 3
- References
- 253
- Related Works
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- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W4406829744Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/mco2.70076Digital Object Identifier
- Title
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Airway stenosis: classification, pathogenesis, and clinical managementWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-01-26Full publication date if available
- Authors
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Pengwei Zhao, Zheng Jiang, Xuexin Li, Mailudan Ainiwaer, Leyu Li, Dejuan Wang, Lixiao Fan, Fei Chen, Jun LiuList of authors in order
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https://doi.org/10.1002/mco2.70076Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1002/mco2.70076Direct OA link when available
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Pathogenesis, Reprogramming, Medicine, Bioinformatics, Disease, Targeted therapy, Genetic enhancement, Microbiome, Computational biology, Cell, Biology, Gene, Immunology, Pathology, Cancer, Genetics, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
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2025: 3Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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