Alcaloides medicinais extraídos de três espécies de Uncarias: genes candidatos envolvidos em sua biossíntese e variabilidade fitoquímica entre as espécies Article Swipe

View

Vanessa Soares de Araújo , Mariana Pires de Campos Telles , Kárita Fernanda de Oliveira Rodrigues Bravo , Ionara Rodrigues Siqueira , Ana Clara Lima Machado , Nathália Cristine Alves do Nascimento , Andressa Morgado Parreira , Bárbara Izarias Barbosa ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.55905/rdelosv18.n71-118

Este estudo aborda a variabilidade fitoquímica e a biossíntese de alcaloides medicinais em três espécies de "unha de gato": Uncaria rhynchophylla, U. tomentosa e U. guianensis. O problema central reside na variação da composição de alcaloides nessas plantas, influenciada por fatores ambientais e genéticos, o que impacta sua padronização para uso farmacêutico. Diante disso, o objetivo foi identificar genes e vias metabólicas envolvidos na biossíntese de alcaloides, além de apontar os fatores externos que afetam essa produção. Para alcançar os objetivos, foi realizada uma revisão sistemática da literatura, seguindo o protocolo PRISMA. A pesquisa foi conduzida nas bases de dados PubMed e Portal de Periódicos da CAPES, utilizando palavras-chave e operadores booleanos. Os critérios de inclusão e exclusão foram aplicados rigorosamente, resultando na seleção de 28 artigos originais para análise qualitativa. Os resultados revelaram que a U. rhynchophylla se destaca pela produção de alcaloides indólicos terpênicos, enquanto U. tomentosa e U. guianensis são ricas em alcaloides oxindólicos. A pesquisa também demonstrou que a produção desses compostos é sensível a fatores como estresse hídrico e luminosidade, e que a regulação molecular envolve genes e fatores de transcrição como UrPIF3 e WRKY. A principal conclusão é que, embora haja avanços, existem lacunas significativas, como a falta de dados genéticos sobre as espécies neotropicais e a escassez de estudos que correlacionem a variabilidade fitoquímica com as propriedades medicinais, destacando a necessidade de futuras pesquisas para otimizar a produção de alcaloides de interesse farmacêutico.

Related Topics

Truth And Reconciliation Commission Of Canada

Reich Ministry Of Public Enlightenment And Propaganda

Concepts

No concepts available.

Metadata

Type: article
Language: pt
Landing Page: https://doi.org/10.55905/rdelosv18.n71-118
OA Status: diamond
OpenAlex ID: https://openalex.org/W4414363238

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4414363238

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.55905/rdelosv18.n71-118

Digital Object Identifier
Title: Alcaloides medicinais extraídos de três espécies de Uncarias: genes candidatos envolvidos em sua biossíntese e variabilidade fitoquímica entre as espécies

Work title
Type: article

OpenAlex work type
Language: pt

Primary language
Publication year: 2025

Year of publication
Publication date: 2025-09-19

Full publication date if available
Authors: Vanessa Soares de Araújo, Mariana Pires de Campos Telles, Kárita Fernanda de Oliveira Rodrigues Bravo, Ionara Rodrigues Siqueira, Ana Clara Lima Machado, Nathália Cristine Alves do Nascimento, Andressa Morgado Parreira, Bárbara Izarias Barbosa

List of authors in order
Landing page: https://doi.org/10.55905/rdelosv18.n71-118

Publisher landing page
Open access: Yes

Whether a free full text is available
OA status: diamond

Open access status per OpenAlex
OA URL: https://doi.org/10.55905/rdelosv18.n71-118

Direct OA link when available
Cited by: 0

Total citation count in OpenAlex

Full payload

id	https://openalex.org/W4414363238
doi	https://doi.org/10.55905/rdelosv18.n71-118
ids.doi	https://doi.org/10.55905/rdelosv18.n71-118
ids.openalex	https://openalex.org/W4414363238
fwci	0.0
type	article
title	Alcaloides medicinais extraídos de três espécies de Uncarias: genes candidatos envolvidos em sua biossíntese e variabilidade fitoquímica entre as espécies
biblio.issue	71
biblio.volume	18
biblio.last_page	e6685
biblio.first_page	e6685
topics[0].id	https://openalex.org/T12649
topics[0].field.id	https://openalex.org/fields/30
topics[0].field.display_name	Pharmacology, Toxicology and Pharmaceutics
topics[0].score	0.996399998664856
topics[0].domain.id	https://openalex.org/domains/1
topics[0].domain.display_name	Life Sciences
topics[0].subfield.id	https://openalex.org/subfields/3004
topics[0].subfield.display_name	Pharmacology
topics[0].display_name	Alkaloids: synthesis and pharmacology
topics[1].id	https://openalex.org/T13124
topics[1].field.id	https://openalex.org/fields/16
topics[1].field.display_name	Chemistry
topics[1].score	0.9092000126838684
topics[1].domain.id	https://openalex.org/domains/3
topics[1].domain.display_name	Physical Sciences
topics[1].subfield.id	https://openalex.org/subfields/1605
topics[1].subfield.display_name	Organic Chemistry
topics[1].display_name	Chemical synthesis and alkaloids
is_xpac	False
apc_list
apc_paid
language	pt
locations[0].id	doi:10.55905/rdelosv18.n71-118
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S2737315313
locations[0].source.issn	1988-5245
locations[0].source.type	journal
locations[0].source.is_oa	True
locations[0].source.issn_l	1988-5245
locations[0].source.is_core	False
locations[0].source.is_in_doaj	False
locations[0].source.display_name	DELOS Desarrollo Local Sostenible
locations[0].source.host_organization	https://openalex.org/P4310321194
locations[0].source.host_organization_name	Servicios Academicos Intercontinentales
locations[0].source.host_organization_lineage	https://openalex.org/P4310321194
locations[0].license
locations[0].pdf_url
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	REVISTA DELOS
locations[0].landing_page_url	https://doi.org/10.55905/rdelosv18.n71-118
indexed_in	crossref
authorships[0].author.id	https://openalex.org/A5108841493
authorships[0].author.orcid
authorships[0].author.display_name	Vanessa Soares de Araújo
authorships[0].author_position	first
authorships[0].raw_author_name	Vanessa Soares de Araújo
authorships[0].is_corresponding	False
authorships[1].author.id	https://openalex.org/A5002069646
authorships[1].author.orcid	https://orcid.org/0000-0002-9023-0007
authorships[1].author.display_name	Mariana Pires de Campos Telles
authorships[1].author_position	middle
authorships[1].raw_author_name	Mariana Pires de Campos Telles
authorships[1].is_corresponding	False
authorships[2].author.id	https://openalex.org/A5033101421
authorships[2].author.orcid
authorships[2].author.display_name	Kárita Fernanda de Oliveira Rodrigues Bravo
authorships[2].author_position	middle
authorships[2].raw_author_name	Kárita Fernanda de Oliveira Rodrigues Bravo
authorships[2].is_corresponding	False
authorships[3].author.id	https://openalex.org/A5077938053
authorships[3].author.orcid	https://orcid.org/0000-0002-4460-0978
authorships[3].author.display_name	Ionara Rodrigues Siqueira
authorships[3].author_position	middle
authorships[3].raw_author_name	Izadora Sant’ana Barrozo de Siqueira
authorships[3].is_corresponding	False
authorships[4].author.id	https://openalex.org/A5032844652
authorships[4].author.orcid	https://orcid.org/0000-0002-0354-3719
authorships[4].author.display_name	Ana Clara Lima Machado
authorships[4].author_position	middle
authorships[4].raw_author_name	Ana Clara Lima Machado
authorships[4].is_corresponding	False
authorships[5].author.id	https://openalex.org/A5068297818
authorships[5].author.orcid	https://orcid.org/0000-0002-9531-1631
authorships[5].author.display_name	Nathália Cristine Alves do Nascimento
authorships[5].author_position	middle
authorships[5].raw_author_name	Nathalia Cristine Alves do Nascimento
authorships[5].is_corresponding	False
authorships[6].author.id	https://openalex.org/A5040990210
authorships[6].author.orcid
authorships[6].author.display_name	Andressa Morgado Parreira
authorships[6].author_position	middle
authorships[6].raw_author_name	Andressa Morgado Parreira
authorships[6].is_corresponding	False
authorships[7].author.id	https://openalex.org/A5030168410
authorships[7].author.orcid
authorships[7].author.display_name	Bárbara Izarias Barbosa
authorships[7].author_position	last
authorships[7].raw_author_name	Bárbara Izarias Barbosa
authorships[7].is_corresponding	False
has_content.pdf	False
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://doi.org/10.55905/rdelosv18.n71-118
open_access.oa_status	diamond
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Alcaloides medicinais extraídos de três espécies de Uncarias: genes candidatos envolvidos em sua biossíntese e variabilidade fitoquímica entre as espécies
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T12649
primary_topic.field.id	https://openalex.org/fields/30
primary_topic.field.display_name	Pharmacology, Toxicology and Pharmaceutics
primary_topic.score	0.996399998664856
primary_topic.domain.id	https://openalex.org/domains/1
primary_topic.domain.display_name	Life Sciences
primary_topic.subfield.id	https://openalex.org/subfields/3004
primary_topic.subfield.display_name	Pharmacology
primary_topic.display_name	Alkaloids: synthesis and pharmacology
cited_by_count	0
locations_count	1
best_oa_location.id	doi:10.55905/rdelosv18.n71-118
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S2737315313
best_oa_location.source.issn	1988-5245
best_oa_location.source.type	journal
best_oa_location.source.is_oa	True
best_oa_location.source.issn_l	1988-5245
best_oa_location.source.is_core	False
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	DELOS Desarrollo Local Sostenible
best_oa_location.source.host_organization	https://openalex.org/P4310321194
best_oa_location.source.host_organization_name	Servicios Academicos Intercontinentales
best_oa_location.source.host_organization_lineage	https://openalex.org/P4310321194
best_oa_location.license
best_oa_location.pdf_url
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	REVISTA DELOS
best_oa_location.landing_page_url	https://doi.org/10.55905/rdelosv18.n71-118
primary_location.id	doi:10.55905/rdelosv18.n71-118
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S2737315313
primary_location.source.issn	1988-5245
primary_location.source.type	journal
primary_location.source.is_oa	True
primary_location.source.issn_l	1988-5245
primary_location.source.is_core	False
primary_location.source.is_in_doaj	False
primary_location.source.display_name	DELOS Desarrollo Local Sostenible
primary_location.source.host_organization	https://openalex.org/P4310321194
primary_location.source.host_organization_name	Servicios Academicos Intercontinentales
primary_location.source.host_organization_lineage	https://openalex.org/P4310321194
primary_location.license
primary_location.pdf_url
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	REVISTA DELOS
primary_location.landing_page_url	https://doi.org/10.55905/rdelosv18.n71-118
publication_date	2025-09-19
publication_year	2025
referenced_works_count	0
abstract_inverted_index.A	92, 157, 190
abstract_inverted_index.O	26
abstract_inverted_index.a	3, 7, 135, 162, 168, 177, 202, 212, 218, 226, 233
abstract_inverted_index.e	6, 23, 42, 59, 101, 109, 116, 149, 173, 175, 182, 188, 211
abstract_inverted_index.o	44, 54, 89
abstract_inverted_index.28	125
abstract_inverted_index.Os	112, 131
abstract_inverted_index.U.	21, 24, 136, 147, 150
abstract_inverted_index.as	208, 222
abstract_inverted_index.da	32, 86, 105
abstract_inverted_index.de	9, 15, 17, 34, 65, 68, 98, 103, 114, 124, 142, 184, 204, 214, 228, 235, 237
abstract_inverted_index.em	12, 154
abstract_inverted_index.na	30, 63, 122
abstract_inverted_index.os	70, 79
abstract_inverted_index.se	138
abstract_inverted_index.é	166, 193
abstract_inverted_index.com	221
abstract_inverted_index.foi	56, 81, 94
abstract_inverted_index.nas	96
abstract_inverted_index.por	39
abstract_inverted_index.que	45, 73, 134, 161, 176, 216
abstract_inverted_index.sua	47
abstract_inverted_index.uma	83
abstract_inverted_index.uso	50
abstract_inverted_index.Este	0
abstract_inverted_index.Para	77
abstract_inverted_index.como	170, 186, 201
abstract_inverted_index.essa	75
abstract_inverted_index.haja	196
abstract_inverted_index.para	49, 128, 231
abstract_inverted_index.pela	140
abstract_inverted_index.que,	194
abstract_inverted_index.são	152
abstract_inverted_index.vias	60
abstract_inverted_index."unha	16
abstract_inverted_index.WRKY.	189
abstract_inverted_index.além	67
abstract_inverted_index.bases	97
abstract_inverted_index.dados	99, 205
abstract_inverted_index.falta	203
abstract_inverted_index.foram	118
abstract_inverted_index.genes	58, 181
abstract_inverted_index.ricas	153
abstract_inverted_index.sobre	207
abstract_inverted_index.três	13
abstract_inverted_index.CAPES,	106
abstract_inverted_index.Diante	52
abstract_inverted_index.Portal	102
abstract_inverted_index.PubMed	100
abstract_inverted_index.UrPIF3	187
abstract_inverted_index.aborda	2
abstract_inverted_index.afetam	74
abstract_inverted_index.desses	164
abstract_inverted_index.disso,	53
abstract_inverted_index.embora	195
abstract_inverted_index.estudo	1
abstract_inverted_index.gato":	18
abstract_inverted_index.nessas	36
abstract_inverted_index.reside	29
abstract_inverted_index.PRISMA.	91
abstract_inverted_index.Uncaria	19
abstract_inverted_index.apontar	69
abstract_inverted_index.artigos	126
abstract_inverted_index.central	28
abstract_inverted_index.destaca	139
abstract_inverted_index.envolve	180
abstract_inverted_index.estudos	215
abstract_inverted_index.existem	198
abstract_inverted_index.fatores	40, 71, 169, 183
abstract_inverted_index.futuras	229
abstract_inverted_index.impacta	46
abstract_inverted_index.lacunas	199
abstract_inverted_index.também	159
abstract_inverted_index.análise	129
abstract_inverted_index.enquanto	146
abstract_inverted_index.escassez	213
abstract_inverted_index.estresse	171
abstract_inverted_index.externos	72
abstract_inverted_index.hídrico	172
abstract_inverted_index.objetivo	55
abstract_inverted_index.otimizar	232
abstract_inverted_index.pesquisa	93, 158
abstract_inverted_index.plantas,	37
abstract_inverted_index.problema	27
abstract_inverted_index.revisão	84
abstract_inverted_index.seguindo	88
abstract_inverted_index.alcançar	78
abstract_inverted_index.aplicados	119
abstract_inverted_index.avanços,	197
abstract_inverted_index.compostos	165
abstract_inverted_index.conduzida	95
abstract_inverted_index.espécies	14, 209
abstract_inverted_index.exclusão	117
abstract_inverted_index.inclusão	115
abstract_inverted_index.interesse	238
abstract_inverted_index.molecular	179
abstract_inverted_index.originais	127
abstract_inverted_index.pesquisas	230
abstract_inverted_index.principal	191
abstract_inverted_index.protocolo	90
abstract_inverted_index.realizada	82
abstract_inverted_index.revelaram	133
abstract_inverted_index.seleção	123
abstract_inverted_index.sensível	167
abstract_inverted_index.tomentosa	22, 148
abstract_inverted_index.alcaloides	10, 35, 143, 155, 236
abstract_inverted_index.ambientais	41
abstract_inverted_index.booleanos.	111
abstract_inverted_index.conclusão	192
abstract_inverted_index.critérios	113
abstract_inverted_index.demonstrou	160
abstract_inverted_index.destacando	225
abstract_inverted_index.envolvidos	62
abstract_inverted_index.genéticos	206
abstract_inverted_index.guianensis	151
abstract_inverted_index.indólicos	144
abstract_inverted_index.medicinais	11
abstract_inverted_index.objetivos,	80
abstract_inverted_index.operadores	110
abstract_inverted_index.produção	141, 163, 234
abstract_inverted_index.resultados	132
abstract_inverted_index.resultando	121
abstract_inverted_index.utilizando	107
abstract_inverted_index.variação	31
abstract_inverted_index.Periódicos	104
abstract_inverted_index.alcaloides,	66
abstract_inverted_index.genéticos,	43
abstract_inverted_index.guianensis.	25
abstract_inverted_index.identificar	57
abstract_inverted_index.literatura,	87
abstract_inverted_index.medicinais,	224
abstract_inverted_index.necessidade	227
abstract_inverted_index.produção.	76
abstract_inverted_index.regulação	178
abstract_inverted_index.biossíntese	8, 64
abstract_inverted_index.composição	33
abstract_inverted_index.fitoquímica	5, 220
abstract_inverted_index.influenciada	38
abstract_inverted_index.metabólicas	61
abstract_inverted_index.neotropicais	210
abstract_inverted_index.propriedades	223
abstract_inverted_index.qualitativa.	130
abstract_inverted_index.sistemática	85
abstract_inverted_index.terpênicos,	145
abstract_inverted_index.correlacionem	217
abstract_inverted_index.luminosidade,	174
abstract_inverted_index.oxindólicos.	156
abstract_inverted_index.rhynchophylla	137
abstract_inverted_index.transcrição	185
abstract_inverted_index.variabilidade	4, 219
abstract_inverted_index.farmacêutico.	51, 239
abstract_inverted_index.padronização	48
abstract_inverted_index.palavras-chave	108
abstract_inverted_index.rhynchophylla,	20
abstract_inverted_index.rigorosamente,	120
abstract_inverted_index.significativas,	200
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	8
citation_normalized_percentile.value	0.52763586
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False