Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations Article Swipe
YOU?
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· 2024
· Open Access
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· DOI: https://doi.org/10.1017/s003329172400076x
Background Although the link between alcohol involvement and behavioral phenotypes (e.g. impulsivity, negative affect, executive function [EF]) is well-established, the directionality of these associations, specificity to stages of alcohol involvement, and extent of shared genetic liability remain unclear. We estimate longitudinal associations between transitions among alcohol milestones, behavioral phenotypes, and indices of genetic risk. Methods Data came from the Collaborative Study on the Genetics of Alcoholism ( n = 3681; ages 11–36). Alcohol transitions (first: drink, intoxication, alcohol use disorder [AUD] symptom, AUD diagnosis), internalizing, and externalizing phenotypes came from the Semi-Structured Assessment for the Genetics of Alcoholism. EF was measured with the Tower of London and Visual Span Tasks. Polygenic scores (PGS) were computed for alcohol-related and behavioral phenotypes. Cox models estimated associations among PGS, behavior, and alcohol milestones. Results Externalizing phenotypes (e.g. conduct disorder symptoms) were associated with future initiation and drinking problems (hazard ratio (HR)⩾1.16). Internalizing (e.g. social anxiety) was associated with hazards for progression from first drink to severe AUD (HR⩾1.55). Initiation and AUD were associated with increased hazards for later depressive symptoms and suicidal ideation (HR⩾1.38), and initiation was associated with increased hazards for future conduct symptoms (HR = 1.60). EF was not associated with alcohol transitions. Drinks per week PGS was linked with increased hazards for alcohol transitions (HR⩾1.06). Problematic alcohol use PGS increased hazards for suicidal ideation (HR = 1.20). Conclusions Behavioral markers of addiction vulnerability precede and follow alcohol transitions, highlighting dynamic, bidirectional relationships between behavior and emerging addiction.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1017/s003329172400076x
- https://www.cambridge.org/core/services/aop-cambridge-core/content/view/A096F9B3DE909B3B6B11625EC88F7B58/S003329172400076Xa.pdf/div-class-title-alcohol-milestones-and-internalizing-externalizing-and-executive-function-longitudinal-and-polygenic-score-associations-div.pdf
- OA Status
- hybrid
- Cited By
- 4
- References
- 122
- Related Works
- 10
- OpenAlex ID
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4396761863Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1017/s003329172400076xDigital Object Identifier
- Title
-
Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associationsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-09Full publication date if available
- Authors
-
Sarah E. Paul, David A. A. Baranger, Emma C. Johnson, Joshua J. Jackson, Aaron J. Gorelik, Alex P. Miller, Alexander S. Hatoum, Wesley K. Thompson, Michael Strube, Danielle M. Dick, Chella Kamarajan, John R. Kramer, Martin H. Plawecki, Grace Chan, Andrey P. Anokhin, David B. Chorlian, Sivan Kinreich, Jacquelyn L. Meyers, Bernice Porjesz, Howard J. Edenberg, Arpana Agrawal, Kathleen K. Bucholz, Ryan BogdanList of authors in order
- Landing page
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https://doi.org/10.1017/s003329172400076xPublisher landing page
- PDF URL
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https://www.cambridge.org/core/services/aop-cambridge-core/content/view/A096F9B3DE909B3B6B11625EC88F7B58/S003329172400076Xa.pdf/div-class-title-alcohol-milestones-and-internalizing-externalizing-and-executive-function-longitudinal-and-polygenic-score-associations-div.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
- OA URL
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https://www.cambridge.org/core/services/aop-cambridge-core/content/view/A096F9B3DE909B3B6B11625EC88F7B58/S003329172400076Xa.pdf/div-class-title-alcohol-milestones-and-internalizing-externalizing-and-executive-function-longitudinal-and-polygenic-score-associations-div.pdfDirect OA link when available
- Concepts
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Psychology, Polygenic risk score, Developmental psychology, Clinical psychology, Executive functions, Psychiatry, Cognition, Biology, Genetics, Single-nucleotide polymorphism, Genotype, GeneTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 4Per-year citation counts (last 5 years)
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122Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.addiction. | 247 |
| abstract_inverted_index.associated | 139, 154, 170, 185, 199 |
| abstract_inverted_index.behavioral | 9, 48, 119 |
| abstract_inverted_index.depressive | 176 |
| abstract_inverted_index.initiation | 142, 183 |
| abstract_inverted_index.phenotypes | 10, 88, 133 |
| abstract_inverted_index.Alcoholism. | 98 |
| abstract_inverted_index.Conclusions | 228 |
| abstract_inverted_index.Problematic | 216 |
| abstract_inverted_index.diagnosis), | 84 |
| abstract_inverted_index.involvement | 7 |
| abstract_inverted_index.milestones, | 47 |
| abstract_inverted_index.milestones. | 130 |
| abstract_inverted_index.phenotypes, | 49 |
| abstract_inverted_index.phenotypes. | 120 |
| abstract_inverted_index.progression | 158 |
| abstract_inverted_index.specificity | 25 |
| abstract_inverted_index.transitions | 44, 74, 214 |
| abstract_inverted_index.(HR⩾1.06). | 215 |
| abstract_inverted_index.(HR⩾1.38), | 181 |
| abstract_inverted_index.(HR⩾1.55). | 165 |
| abstract_inverted_index.associations | 42, 124 |
| abstract_inverted_index.highlighting | 239 |
| abstract_inverted_index.impulsivity, | 12 |
| abstract_inverted_index.involvement, | 30 |
| abstract_inverted_index.longitudinal | 41 |
| abstract_inverted_index.transitions, | 238 |
| abstract_inverted_index.transitions. | 202 |
| abstract_inverted_index.(HR)⩾1.16). | 148 |
| abstract_inverted_index.Collaborative | 60 |
| abstract_inverted_index.Externalizing | 132 |
| abstract_inverted_index.Internalizing | 149 |
| abstract_inverted_index.associations, | 24 |
| abstract_inverted_index.bidirectional | 241 |
| abstract_inverted_index.externalizing | 87 |
| abstract_inverted_index.intoxication, | 77 |
| abstract_inverted_index.relationships | 242 |
| abstract_inverted_index.vulnerability | 233 |
| abstract_inverted_index.directionality | 21 |
| abstract_inverted_index.internalizing, | 85 |
| abstract_inverted_index.Semi-Structured | 92 |
| abstract_inverted_index.alcohol-related | 117 |
| abstract_inverted_index.well-established, | 19 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 97 |
| corresponding_author_ids | https://openalex.org/A5047634574 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 23 |
| corresponding_institution_ids | https://openalex.org/I204465549 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8299999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.89394505 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |