Alfaxalone does not have long‐term effects on goldfish pyramidal neuron action potential properties or GABA A receptor currents
Article Swipe
Domenic Di Stefano
,
Haushe Suganthan
,
Leslie T. Buck
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/2211-5463.13777
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/2211-5463.13777
Anesthetics have varying physiological effects, but most notably alter ion channel kinetics. Alfaxalone is a rapid induction and washout neuroactive anesthetic, which potentiates γ‐aminobutyric acid (GABA)‐activated GABA A receptor (GABA A ‐R) currents. This study aims to identify any long‐term effects of alfaxalone sedation on pyramidal neuron action potential and GABA A ‐R properties, to determine if its impact on neuronal function can be reversed in a sufficiently short timeframe to allow for same‐day electrophysiological studies in goldfish brain. The goldfish ( Carassius auratus ) is an anoxia‐tolerant vertebrate and is a useful model to study anoxia tolerance mechanisms. The results show that alfaxalone sedation did not significantly impact action potential properties. Additionally, the acute application of alfaxalone onto naive brain slices caused the potentiation of whole‐cell GABA A ‐R current decay time and area under the curve. Following whole‐animal sedation with alfaxalone, a 3‐h wash of brain slices in alfaxalone‐free saline, with saline exchanged every 30 min, was required to remove any potentiating impact of alfaxalone on GABA A ‐R whole‐cell currents. These results demonstrate that alfaxalone is an effective anesthetic for same‐day electrophysiological experiments with goldfish brain slices.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/2211-5463.13777
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/2211-5463.13777
- OA Status
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- References
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- OpenAlex ID
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- DOI
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https://doi.org/10.1002/2211-5463.13777Digital Object Identifier
- Title
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Alfaxalone does not have long‐term effects on goldfish pyramidal neuron action potential properties or
GABA A receptor currentsWork title - Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-02-11Full publication date if available
- Authors
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Domenic Di Stefano, Haushe Suganthan, Leslie T. BuckList of authors in order
- Landing page
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https://doi.org/10.1002/2211-5463.13777Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/2211-5463.13777Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/2211-5463.13777Direct OA link when available
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Electrophysiology, Anesthetic, Long-term potentiation, Washout, Sedation, Pharmacology, Chemistry, Anesthesia, Neuroscience, Receptor, Biology, Medicine, Internal medicine, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| referenced_works_count | 92 |
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| corresponding_author_ids | https://openalex.org/A5101712823, https://openalex.org/A5013454860 |
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