Algorithmic robustness to preferred orientations in single particle analysis by CryoEM Article Swipe
Carlos Óscar S. Sorzano
,
Dmitry A. Semchonok
,
Su‐Chang Lin
,
Yi‐Ching Lo
,
José Luis Vilas
,
Amaya Jiménez-Moreno
,
Marcos Gragera
,
Santiago Vacca
,
David Maluenda
,
Marta Martínez
,
Erney Ramírez-Aportela
,
R. Melero
,
Ana Cuervo
,
José Javier Conesa
,
Pablo Conesa
,
Patricia Losana
,
Laura del Caño
,
J. Jiménez de la Morena
,
Yunior C. Fonseca
,
Rubén Sánchez-García
,
David Střelák
,
E. Fernández-Giménez
,
F. de Isidro
,
David Herreros
,
Panagiotis L. Kastritis
,
R. Marabini
,
Barry D. Bruce
,
J.M. Carazo
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1016/j.jsb.2020.107695
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1016/j.jsb.2020.107695
The presence of preferred orientations in single particle analysis (SPA) by cryo-Electron Microscopy (cryoEM) is currently one of the hurdles preventing many structural analyses from yielding high-resolution structures. Although the existence of preferred orientations is mostly related to the grid preparation, in this technical note, we show that some image processing algorithms used for angular assignment and three-dimensional (3D) reconstruction are more robust than others to these detrimental conditions. We exemplify this argument with three different data sets in which the presence of preferred orientations hindered achieving a 3D reconstruction without artifacts or, even worse, a 3D reconstruction could never be achieved.
Related Topics
Concepts
Robustness (evolution)
3D reconstruction
Single particle analysis
Grid
Computer science
3d model
Cryo-electron microscopy
Particle (ecology)
Algorithm
Artificial intelligence
Computer vision
Mathematics
Geometry
Physics
Chemistry
Biology
Nuclear magnetic resonance
Aerosol
Biochemistry
Meteorology
Ecology
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jsb.2020.107695
- https://www.sciencedirect.com/science/article/pii/S1047847720302689?via%3Dihub
- OA Status
- hybrid
- Cited By
- 35
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3119556445
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3119556445Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.jsb.2020.107695Digital Object Identifier
- Title
-
Algorithmic robustness to preferred orientations in single particle analysis by CryoEMWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-01-09Full publication date if available
- Authors
-
Carlos Óscar S. Sorzano, Dmitry A. Semchonok, Su‐Chang Lin, Yi‐Ching Lo, José Luis Vilas, Amaya Jiménez-Moreno, Marcos Gragera, Santiago Vacca, David Maluenda, Marta Martínez, Erney Ramírez-Aportela, R. Melero, Ana Cuervo, José Javier Conesa, Pablo Conesa, Patricia Losana, Laura del Caño, J. Jiménez de la Morena, Yunior C. Fonseca, Rubén Sánchez-García, David Střelák, E. Fernández-Giménez, F. de Isidro, David Herreros, Panagiotis L. Kastritis, R. Marabini, Barry D. Bruce, J.M. CarazoList of authors in order
- Landing page
-
https://doi.org/10.1016/j.jsb.2020.107695Publisher landing page
- PDF URL
-
https://www.sciencedirect.com/science/article/pii/S1047847720302689?via%3DihubDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://www.sciencedirect.com/science/article/pii/S1047847720302689?via%3DihubDirect OA link when available
- Concepts
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Robustness (evolution), 3D reconstruction, Single particle analysis, Grid, Computer science, 3d model, Cryo-electron microscopy, Particle (ecology), Algorithm, Artificial intelligence, Computer vision, Mathematics, Geometry, Physics, Chemistry, Biology, Nuclear magnetic resonance, Aerosol, Biochemistry, Meteorology, Ecology, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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35Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 8, 2023: 9, 2022: 7, 2021: 6Per-year citation counts (last 5 years)
- References (count)
-
31Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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