Allergic airway inflammation amplifies mast cell responses in isolated guinea pig intralobular bronchi Article Swipe

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Mu Nie , Jielu Liu , Yujiao Xiang , Yiu Tung Anthony Wong , Emma Hendriks , Gunnar Nilsson , Jesper Säfholm , Mikael Adner ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1152/ajplung.00422.2024

A protocol to avoid postmortem constriction in isolated intralobular bronchi from guinea pigs was established. A new model makes it possible to investigate bronchial responses in airways with asthmatic features. Increased responses in bronchi from the guinea pig asthma model suggest the importance of mast cells in asthma.

Related Topics

Transcutaneous Electrical Nerve Stimulation

Biochemistry

Platelet

Concepts

Bronchoconstriction Histamine Carbachol Leukotriene Guinea pig Prostaglandin D2 Leukotriene D4 Leukotriene C4 Immunology Eicosanoid Mast cell Thromboxane Medicine Thromboxane A2 House dust mite Prostaglandin Asthma Endocrinology Chemistry Allergy Arachidonic acid Allergen Stimulation Biochemistry Enzyme Platelet

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Type: article
Language: en
Landing Page: https://doi.org/10.1152/ajplung.00422.2024
OA Status: bronze
Cited By: 1
References: 46
Related Works: 10
OpenAlex ID: https://openalex.org/W4408566763

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OpenAlex ID: https://openalex.org/W4408566763

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DOI: https://doi.org/10.1152/ajplung.00422.2024

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Title: Allergic airway inflammation amplifies mast cell responses in isolated guinea pig intralobular bronchi

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Type: article

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Language: en

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Publication year: 2025

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Publication date: 2025-03-18

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Authors: Mu Nie, Jielu Liu, Yujiao Xiang, Yiu Tung Anthony Wong, Emma Hendriks, Gunnar Nilsson, Jesper Säfholm, Mikael Adner

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Landing page: https://doi.org/10.1152/ajplung.00422.2024

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Open access: Yes

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OA status: bronze

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OA URL: https://doi.org/10.1152/ajplung.00422.2024

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Concepts: Bronchoconstriction, Histamine, Carbachol, Leukotriene, Guinea pig, Prostaglandin D2, Leukotriene D4, Leukotriene C4, Immunology, Eicosanoid, Mast cell, Thromboxane, Medicine, Thromboxane A2, House dust mite, Prostaglandin, Asthma, Endocrinology, Chemistry, Allergy, Arachidonic acid, Allergen, Stimulation, Biochemistry, Enzyme, Platelet

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Cited by: 1

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Citations by year (recent): 2025: 1

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References (count): 46

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Related works (count): 10

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