Alpha-linolenic acid rich Allium porrum methanolic extract potentially inhibits HT-115 human colon cancer cells proliferation via mitochondria mediated apoptotic mechanism Article Swipe
Ghedeir M. Alshammari
,
Aristatile Balakrishnan
,
Pandurangan Subash‐Babu
,
Abdulrahman S. Al‐Khalifa
,
Ali A. Alshatwi
,
Abu ElGasim A. Yagoub
,
Laila Naif Al‐Harbi
,
Ghaliah Hamed Alshamlan
,
Norah A. Albekairi
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1016/j.jksus.2021.101736
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1016/j.jksus.2021.101736
Colon cancer is the third most devastating cancer type in morbidity and mortality associated with severe comorbidities in developing and developed countries. Dietary supplementation of alpha-linolenic acid has a beneficial effect on intestinal dysfunction. In the present study, we processed Allium porrum (Leek) for extraction and identified the bioactive metabolites with the potential of antiproliferative effect in HT-115 (human colon carcinoma) cells. We preliminarily analyzed the cytotoxic effects of methanol, chloroform, and hexane extracts of leek on HT-115 cells. In vitro cytotoxicity assay revealed that leek methanol extract (LME) significantly prohibited cell proliferation in a dose-as well as time-dependent manner, compared with hexane and chloroform extracts of leek. We found that LME at 0.4 and 0.2 μg/mL inhibited HT-115 cell proliferation by 50% at both 24 and 48 h. Cell morphological analysis and nuclear staining indicated that 22% of cells became apoptotic and ∼4% were necrotic after treatment with 0.4 μg/mL of LME. RT-PCR and western blot analysis showed that mRNA and protein expression levels of apoptotic markers such as p53, Bax, caspase-9, and caspase-3 were up-regulated, whereas Bcl-2 was down-regulated in cells exposed with 0.4 μg/mL LME, compared with the levels in untreated control cells. Lipid peroxidation marker (LPO) was significantly elevated in LME-treated cell lysates. The activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were significantly decreased in LME-treated cell lysates when compared with control HT-115 cells. In conclusion, the observed results demonstrate that LME significantly inhibits colon cancer cell growth via the mitochondria mediated caspase-dependent apoptosis mechanism.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jksus.2021.101736
- OA Status
- gold
- Cited By
- 4
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3216777394
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3216777394Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.jksus.2021.101736Digital Object Identifier
- Title
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Alpha-linolenic acid rich Allium porrum methanolic extract potentially inhibits HT-115 human colon cancer cells proliferation via mitochondria mediated apoptotic mechanismWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-11-27Full publication date if available
- Authors
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Ghedeir M. Alshammari, Aristatile Balakrishnan, Pandurangan Subash‐Babu, Abdulrahman S. Al‐Khalifa, Ali A. Alshatwi, Abu ElGasim A. Yagoub, Laila Naif Al‐Harbi, Ghaliah Hamed Alshamlan, Norah A. AlbekairiList of authors in order
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https://doi.org/10.1016/j.jksus.2021.101736Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.jksus.2021.101736Direct OA link when available
- Concepts
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Apoptosis, Superoxide dismutase, Molecular biology, Biology, Cytotoxicity, Lipid peroxidation, Cell growth, Biochemistry, Chemistry, Oxidative stress, In vitroTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2024: 3, 2023: 1Per-year citation counts (last 5 years)
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41Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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