Alteration in topological properties of brain functional network after 2‐year high altitude exposure: A panel study Article Swipe
Zhenlong Xin
,
Xiaoming Chen
,
Qian Zhang
,
Jiye Wang
,
Yi‐Bin Xi
,
Jian Liu
,
Baojuan Li
,
Xiaoru Dong
,
Yiwen Lin
,
Wenbin Zhang
,
Jingyuan Chen
,
Wenjing Luo
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1002/brb3.1656
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1002/brb3.1656
Introduction High altitude (HA) exposure leads to cognitive impairment while the underlying mechanism is still unclear. Brain functional network is crucial for advanced functions, and its alteration is implicated in cognitive decline in multiple diseases. The aim of current study was to investigate the topological changes in HA‐exposed brain functional network. Methods Based on Shaanxi‐Tibet immigrant cohort, neuropsychological tests and resting‐state functional MRI were applied to evaluate the participants' cognitive function and functional connection (FC) changes, respectively. GRETNA toolbox was used to construct the brain functional network. The gray matter was parcellated into 116 anatomically defined regions according to Automated Anatomical Labeling atlas. Subsequently, the mean time series for each of the 116 regions were extracted and computed for Pearson's correlation coefficients. The relation matrix was further processed and seen as brain functional network. Correlation between functional network changes and neuropsychological results was also examined. Results The cognitive performance was impaired by HA exposure as indicated by neuropsychological test. HA exposure led to alterations of degree centrality and nodal efficiency in multiple brain regions. Moreover, two subnetworks were extracted in which the FCs significantly decreased after exposure. In addition, the alterations in FCs within above two subnetworks were significantly correlated with changes of memory and reaction time. Conclusions Our results suggest that HA exposure modulates the topological property of functional network and FCs of some important regions, which may impair the attention, perception, memory, motion ignition, and modulation processes, finally decreasing cognitive performance in neuropsychological tests.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/brb3.1656
- OA Status
- gold
- Cited By
- 14
- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3085270896
All OpenAlex metadata
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https://openalex.org/W3085270896Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/brb3.1656Digital Object Identifier
- Title
-
Alteration in topological properties of brain functional network after 2‐year high altitude exposure: A panel studyWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-09-09Full publication date if available
- Authors
-
Zhenlong Xin, Xiaoming Chen, Qian Zhang, Jiye Wang, Yi‐Bin Xi, Jian Liu, Baojuan Li, Xiaoru Dong, Yiwen Lin, Wenbin Zhang, Jingyuan Chen, Wenjing LuoList of authors in order
- Landing page
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https://doi.org/10.1002/brb3.1656Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1002/brb3.1656Direct OA link when available
- Concepts
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Effects of high altitude on humans, Topology (electrical circuits), Functional connectivity, Computer science, Neuroscience, Biology, Physics, Mathematics, Meteorology, CombinatoricsTop concepts (fields/topics) attached by OpenAlex
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14Total citation count in OpenAlex
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2025: 2, 2024: 4, 2023: 3, 2022: 4, 2021: 1Per-year citation counts (last 5 years)
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39Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I9916479 |
| citation_normalized_percentile.value | 0.73158647 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |