Alteration in Urease-producing Bacteria in the Gut Microbiomes of Patients with Inflammatory Bowel Diseases Article Swipe
Ron Ryvchin
,
Vadim Dubinsky
,
Keren M. Rabinowitz
,
Nir Wasserberg
,
Iris Dotan
,
Uri Gophna
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1093/ecco-jcc/jjab101
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1093/ecco-jcc/jjab101
Background and Aims Bacterial urease is a major virulence factor of human pathogens, and murine models have shown that it can contribute to the pathogenesis of inflammatory bowel diseases [IBD]. Methods The distribution of urease-producing bacteria in IBD was assessed using public faecal metagenomic data from various cohorts, including non-IBD controls [n = 55], patients with Crohn’s disease [n = 291] or ulcerative colitis [n = 214], and patients with a pouch [n = 53]. The ureA gene and the taxonomic markers gyrA, rpoB, and recA were used to estimate the percentage of urease producers in each sample. Results Levels of urease producers in patients with IBD and non-IBD controls were comparable. In non-IBD controls and most IBD patients, urease producers were primarily acetate-producing genera such as Blautia and Ruminococcus. A shift in the type of the dominant urease producers towards Proteobacteria and Bacilli was observed in a subset of all IBD subtypes, which correlated with faecal calprotectin levels in one cohort. Some patients with IBD had no detectable urease producers. In patients with a pouch, the probiotic-associated species Streptococcus thermophilus was more common as a main urease producer than in other IBD phenotypes, and it generally did not co-occur with other Bacilli or with Proteobacteria. Conclusions Unlike all non-IBD controls, patients with IBD often showed a shift towards Bacilli or Proteobacteria or a complete loss of urease production. Probiotics containing the species S. thermophilus may have a protective effect against colonisation by undesirable urease-producing bacteria in a subset of patients with a pouch.
Related Topics
Concepts
Microbiology
Inflammatory bowel disease
Urease
Aztreonam
Biology
Dysbiosis
Pouchitis
Fusobacteria
Medicine
Bacteria
Immunology
Proteobacteria
Internal medicine
Antibiotics
Gut flora
Disease
Antibiotic resistance
Urea
Genetics
Imipenem
16S ribosomal RNA
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/ecco-jcc/jjab101
- https://academic.oup.com/ecco-jcc/article-pdf/15/12/2066/41818833/jjab101.pdf
- OA Status
- bronze
- Cited By
- 24
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3166691437
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3166691437Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/ecco-jcc/jjab101Digital Object Identifier
- Title
-
Alteration in Urease-producing Bacteria in the Gut Microbiomes of Patients with Inflammatory Bowel DiseasesWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-06-08Full publication date if available
- Authors
-
Ron Ryvchin, Vadim Dubinsky, Keren M. Rabinowitz, Nir Wasserberg, Iris Dotan, Uri GophnaList of authors in order
- Landing page
-
https://doi.org/10.1093/ecco-jcc/jjab101Publisher landing page
- PDF URL
-
https://academic.oup.com/ecco-jcc/article-pdf/15/12/2066/41818833/jjab101.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/ecco-jcc/article-pdf/15/12/2066/41818833/jjab101.pdfDirect OA link when available
- Concepts
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Microbiology, Inflammatory bowel disease, Urease, Aztreonam, Biology, Dysbiosis, Pouchitis, Fusobacteria, Medicine, Bacteria, Immunology, Proteobacteria, Internal medicine, Antibiotics, Gut flora, Disease, Antibiotic resistance, Urea, Genetics, Imipenem, 16S ribosomal RNA, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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24Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 10, 2024: 3, 2023: 8, 2022: 3Per-year citation counts (last 5 years)
- References (count)
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58Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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