Alteration of the Respiratory Microbiome in Hospitalized Patients with Asthma–COPD Overlap during and after an Exacerbation Article Swipe
Ahmad R. Alsayed
,
Anas Abed
,
Yazun Jarrar
,
Farhan Alshammari
,
Bushra Alshammari
,
Iman A. Basheti
,
Malek Zihlif
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/jcm12062118
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/jcm12062118
The immediate aim of this study was to comparatively examine the bacterial respiratory microbiome of patients in a stable state and during an exacerbation of asthma–COPD (chronic obstructive pulmonary disease) overlap (ACO). This prospective observational study took place in Jordan between 1 September 2021 and 30 April 2022. Sputum samples from patients with recognized ACO were acquired within 48 h of the exacerbation onset and again at 3 weeks following the exacerbation. The next-generation sequencing Illumina MiSeq was employed and uncovered significantly high bacterial diversity in the sputa. The results showed a significant decrease in the taxonomic richness in the sputum samples collected during the exacerbation episodes compared with those collected from patients in a stable state (p = 0.008), with an increase in the taxonomic evenness (p < 0.005). This change in the composition of the airway bacterial community suggests that the replacement of a significant portion of the airway microbiome with certain microorganisms may play a role in the decrease in microbial diversity observed during an ACO exacerbation. Greater knowledge of this link could allow for a more focused administration of antibiotics, especially during exacerbations, improving clinical efficacy and patient outcomes.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm12062118
- https://www.mdpi.com/2077-0383/12/6/2118/pdf?version=1678271939
- OA Status
- gold
- Cited By
- 15
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4323664696
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4323664696Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/jcm12062118Digital Object Identifier
- Title
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Alteration of the Respiratory Microbiome in Hospitalized Patients with Asthma–COPD Overlap during and after an ExacerbationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-03-08Full publication date if available
- Authors
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Ahmad R. Alsayed, Anas Abed, Yazun Jarrar, Farhan Alshammari, Bushra Alshammari, Iman A. Basheti, Malek ZihlifList of authors in order
- Landing page
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https://doi.org/10.3390/jcm12062118Publisher landing page
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https://www.mdpi.com/2077-0383/12/6/2118/pdf?version=1678271939Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2077-0383/12/6/2118/pdf?version=1678271939Direct OA link when available
- Concepts
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Medicine, Microbiome, Exacerbation, Asthma, COPD, Respiratory system, Asthma exacerbations, Copd exacerbation, Intensive care medicine, Internal medicine, Bioinformatics, Acute exacerbation of chronic obstructive pulmonary disease, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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15Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 4, 2023: 8Per-year citation counts (last 5 years)
- References (count)
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61Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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