Altered antibody profiles after receipt of third dose SARS-CoV-2 mRNA vaccines in solid organ transplant recipients Article Swipe
J. Lee
,
Janna R. Shapiro
,
John S. Lee
,
Ioannis Sitaris
,
Stephanie R. Peralta
,
Maggie Li
,
Camille Wouters
,
Andrew H. Karaba
,
Joel N. Blankson
,
Aaron A.R. Tobian
,
William A. Werbel
,
Andrew Pekosz
,
Sabra L. Klein
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.4049/jimmunol.210.supp.252.16
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.4049/jimmunol.210.supp.252.16
Immunosuppressed patients, including solid organ transplant recipients (SOTRs), developed significantly lower antibody responses and had more breakthrough infections after two doses of COVID-19 mRNA vaccines, as compared with immunocompetent individuals. The aim of this study was to characterize vaccine-induced antibody responses, including IgG binding antibodies and live virus neutralizing antibodies (NAb) against the vaccine strain and Omicron variants, BA.1 and BA.5, as well as the levels of the IgG subclasses, IgG1-4, in SOTRs. Serum samples from SOTRs were analyzed at pre-vaccination, 30-days, and 90-days following the third dose COVID-19 mRNA vaccines (D3). For several measures, antibody responses were compared with healthy controls (HC). A third dose vaccination increased anti-spike (S) IgG titers in response to the SARS-CoV-2 vaccine and Omicron variants from pre- to post-D3 in SOTRs. Anti-S IgG responses to Omicron variants, however, were significantly lower than to the vaccine strain. SOTRs also had low live virus NAb titers to the vaccine and Omicron BA.1 variant, with many individuals having no detectable NAb. The subclass-specific anti-S IgG antibodies against the SARS-CoV-2 vaccine strain predominantly consisted of IgG1, IgG3, and IgG4 in SOTRs, which resembled the subclass profiles in HC at post-D3. Together, our findings illustrate that while a booster dose of mRNA vaccine induces antibody responses, including IgG1 and IgG3, which are the dominant antiviral IgG subclasses, in SOTRs, these responses are still lower than immunocompetent individuals. Therefore, consideration should be given to different formulations and doses of COVID-19 vaccines in people with severely compromised immune systems.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4049/jimmunol.210.supp.252.16
- https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/252.16/1632488/252_16.pdf
- OA Status
- bronze
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4385685449
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4385685449Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.4049/jimmunol.210.supp.252.16Digital Object Identifier
- Title
-
Altered antibody profiles after receipt of third dose SARS-CoV-2 mRNA vaccines in solid organ transplant recipientsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-05-01Full publication date if available
- Authors
-
J. Lee, Janna R. Shapiro, John S. Lee, Ioannis Sitaris, Stephanie R. Peralta, Maggie Li, Camille Wouters, Andrew H. Karaba, Joel N. Blankson, Aaron A.R. Tobian, William A. Werbel, Andrew Pekosz, Sabra L. KleinList of authors in order
- Landing page
-
https://doi.org/10.4049/jimmunol.210.supp.252.16Publisher landing page
- PDF URL
-
https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/252.16/1632488/252_16.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/252.16/1632488/252_16.pdfDirect OA link when available
- Concepts
-
Antibody, Titer, Virology, Vaccination, Subclass, Neutralizing antibody, Virus, Immunology, Immune system, Antibody titer, Medicine, Immunoglobulin G, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4385685449 |
|---|---|
| doi | https://doi.org/10.4049/jimmunol.210.supp.252.16 |
| ids.doi | https://doi.org/10.4049/jimmunol.210.supp.252.16 |
| ids.openalex | https://openalex.org/W4385685449 |
| fwci | 0.0 |
| type | article |
| title | Altered antibody profiles after receipt of third dose SARS-CoV-2 mRNA vaccines in solid organ transplant recipients |
| biblio.issue | Supplement_1 |
| biblio.volume | 210 |
| biblio.last_page | 252.16 |
| biblio.first_page | 252.16 |
| topics[0].id | https://openalex.org/T10118 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2725 |
| topics[0].subfield.display_name | Infectious Diseases |
| topics[0].display_name | SARS-CoV-2 and COVID-19 Research |
| topics[1].id | https://openalex.org/T11016 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9976999759674072 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2741 |
| topics[1].subfield.display_name | Radiology, Nuclear Medicine and Imaging |
| topics[1].display_name | Monoclonal and Polyclonal Antibodies Research |
| topics[2].id | https://openalex.org/T11495 |
| topics[2].field.id | https://openalex.org/fields/11 |
| topics[2].field.display_name | Agricultural and Biological Sciences |
| topics[2].score | 0.9973999857902527 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1103 |
| topics[2].subfield.display_name | Animal Science and Zoology |
| topics[2].display_name | Animal Virus Infections Studies |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C159654299 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7095084190368652 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q79460 |
| concepts[0].display_name | Antibody |
| concepts[1].id | https://openalex.org/C32611913 |
| concepts[1].level | 3 |
| concepts[1].score | 0.672115683555603 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q2166189 |
| concepts[1].display_name | Titer |
| concepts[2].id | https://openalex.org/C159047783 |
| concepts[2].level | 1 |
| concepts[2].score | 0.6707357168197632 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7215 |
| concepts[2].display_name | Virology |
| concepts[3].id | https://openalex.org/C22070199 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6426022052764893 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q192995 |
| concepts[3].display_name | Vaccination |
| concepts[4].id | https://openalex.org/C2776194381 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5697869658470154 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q3965271 |
| concepts[4].display_name | Subclass |
| concepts[5].id | https://openalex.org/C2779261636 |
| concepts[5].level | 3 |
| concepts[5].score | 0.5302286744117737 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7003054 |
| concepts[5].display_name | Neutralizing antibody |
| concepts[6].id | https://openalex.org/C2522874641 |
| concepts[6].level | 2 |
| concepts[6].score | 0.5042461156845093 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q808 |
| concepts[6].display_name | Virus |
| concepts[7].id | https://openalex.org/C203014093 |
| concepts[7].level | 1 |
| concepts[7].score | 0.5002601146697998 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[7].display_name | Immunology |
| concepts[8].id | https://openalex.org/C8891405 |
| concepts[8].level | 2 |
| concepts[8].score | 0.4552608132362366 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[8].display_name | Immune system |
| concepts[9].id | https://openalex.org/C22889606 |
| concepts[9].level | 4 |
| concepts[9].score | 0.4505125880241394 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q2166189 |
| concepts[9].display_name | Antibody titer |
| concepts[10].id | https://openalex.org/C71924100 |
| concepts[10].level | 0 |
| concepts[10].score | 0.438468873500824 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[10].display_name | Medicine |
| concepts[11].id | https://openalex.org/C2780898057 |
| concepts[11].level | 3 |
| concepts[11].score | 0.42897728085517883 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q79448 |
| concepts[11].display_name | Immunoglobulin G |
| concepts[12].id | https://openalex.org/C86803240 |
| concepts[12].level | 0 |
| concepts[12].score | 0.3601859211921692 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[12].display_name | Biology |
| keywords[0].id | https://openalex.org/keywords/antibody |
| keywords[0].score | 0.7095084190368652 |
| keywords[0].display_name | Antibody |
| keywords[1].id | https://openalex.org/keywords/titer |
| keywords[1].score | 0.672115683555603 |
| keywords[1].display_name | Titer |
| keywords[2].id | https://openalex.org/keywords/virology |
| keywords[2].score | 0.6707357168197632 |
| keywords[2].display_name | Virology |
| keywords[3].id | https://openalex.org/keywords/vaccination |
| keywords[3].score | 0.6426022052764893 |
| keywords[3].display_name | Vaccination |
| keywords[4].id | https://openalex.org/keywords/subclass |
| keywords[4].score | 0.5697869658470154 |
| keywords[4].display_name | Subclass |
| keywords[5].id | https://openalex.org/keywords/neutralizing-antibody |
| keywords[5].score | 0.5302286744117737 |
| keywords[5].display_name | Neutralizing antibody |
| keywords[6].id | https://openalex.org/keywords/virus |
| keywords[6].score | 0.5042461156845093 |
| keywords[6].display_name | Virus |
| keywords[7].id | https://openalex.org/keywords/immunology |
| keywords[7].score | 0.5002601146697998 |
| keywords[7].display_name | Immunology |
| keywords[8].id | https://openalex.org/keywords/immune-system |
| keywords[8].score | 0.4552608132362366 |
| keywords[8].display_name | Immune system |
| keywords[9].id | https://openalex.org/keywords/antibody-titer |
| keywords[9].score | 0.4505125880241394 |
| keywords[9].display_name | Antibody titer |
| keywords[10].id | https://openalex.org/keywords/medicine |
| keywords[10].score | 0.438468873500824 |
| keywords[10].display_name | Medicine |
| keywords[11].id | https://openalex.org/keywords/immunoglobulin-g |
| keywords[11].score | 0.42897728085517883 |
| keywords[11].display_name | Immunoglobulin G |
| keywords[12].id | https://openalex.org/keywords/biology |
| keywords[12].score | 0.3601859211921692 |
| keywords[12].display_name | Biology |
| language | en |
| locations[0].id | doi:10.4049/jimmunol.210.supp.252.16 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S38008053 |
| locations[0].source.issn | 0022-1767, 1550-6606 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0022-1767 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | The Journal of Immunology |
| locations[0].source.host_organization | https://openalex.org/P4320800377 |
| locations[0].source.host_organization_name | American Association of Immunologists |
| locations[0].source.host_organization_lineage | https://openalex.org/P4320800377 |
| locations[0].source.host_organization_lineage_names | American Association of Immunologists |
| locations[0].license | |
| locations[0].pdf_url | https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/252.16/1632488/252_16.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | The Journal of Immunology |
| locations[0].landing_page_url | https://doi.org/10.4049/jimmunol.210.supp.252.16 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5071431476 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | J. Lee |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I1299907687 |
| authorships[0].affiliations[0].raw_affiliation_string | 1Johns Hopkins Bloomberg Sch. of Public Hlth. |
| authorships[0].institutions[0].id | https://openalex.org/I1299907687 |
| authorships[0].institutions[0].ror | https://ror.org/02rdpzb15 |
| authorships[0].institutions[0].type | company |
| authorships[0].institutions[0].lineage | https://openalex.org/I1299907687 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Bloomberg (United States) |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Jenny MinChen Lee |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | 1Johns Hopkins Bloomberg Sch. of Public Hlth. |
| authorships[1].author.id | https://openalex.org/A5091080570 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-8088-2506 |
| authorships[1].author.display_name | Janna R. Shapiro |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I1299907687 |
| authorships[1].affiliations[0].raw_affiliation_string | 1Johns Hopkins Bloomberg Sch. of Public Hlth. |
| authorships[1].institutions[0].id | https://openalex.org/I1299907687 |
| authorships[1].institutions[0].ror | https://ror.org/02rdpzb15 |
| authorships[1].institutions[0].type | company |
| authorships[1].institutions[0].lineage | https://openalex.org/I1299907687 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Bloomberg (United States) |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Janna R. Shapiro |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | 1Johns Hopkins Bloomberg Sch. of Public Hlth. |
| authorships[2].author.id | https://openalex.org/A5101515019 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-7605-1814 |
| authorships[2].author.display_name | John S. Lee |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1299907687 |
| authorships[2].affiliations[0].raw_affiliation_string | 1Johns Hopkins Bloomberg Sch. of Public Hlth. |
| authorships[2].institutions[0].id | https://openalex.org/I1299907687 |
| authorships[2].institutions[0].ror | https://ror.org/02rdpzb15 |
| authorships[2].institutions[0].type | company |
| authorships[2].institutions[0].lineage | https://openalex.org/I1299907687 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Bloomberg (United States) |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | John S. Lee |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | 1Johns Hopkins Bloomberg Sch. of Public Hlth. |
| authorships[3].author.id | https://openalex.org/A5001107142 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Ioannis Sitaris |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I1299907687 |
| authorships[3].affiliations[0].raw_affiliation_string | 1Johns Hopkins Bloomberg Sch. of Public Hlth. |
| authorships[3].institutions[0].id | https://openalex.org/I1299907687 |
| authorships[3].institutions[0].ror | https://ror.org/02rdpzb15 |
| authorships[3].institutions[0].type | company |
| authorships[3].institutions[0].lineage | https://openalex.org/I1299907687 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Bloomberg (United States) |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Ioannis Sitaris |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | 1Johns Hopkins Bloomberg Sch. of Public Hlth. |
| authorships[4].author.id | https://openalex.org/A5113031068 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Stephanie R. Peralta |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I1299907687 |
| authorships[4].affiliations[0].raw_affiliation_string | 1Johns Hopkins Bloomberg Sch. of Public Hlth. |
| authorships[4].institutions[0].id | https://openalex.org/I1299907687 |
| authorships[4].institutions[0].ror | https://ror.org/02rdpzb15 |
| authorships[4].institutions[0].type | company |
| authorships[4].institutions[0].lineage | https://openalex.org/I1299907687 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Bloomberg (United States) |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Stephanie R. Peralta |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | 1Johns Hopkins Bloomberg Sch. of Public Hlth. |
| authorships[5].author.id | https://openalex.org/A5033734741 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Maggie Li |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I1299907687 |
| authorships[5].affiliations[0].raw_affiliation_string | 1Johns Hopkins Bloomberg Sch. of Public Hlth. |
| authorships[5].institutions[0].id | https://openalex.org/I1299907687 |
| authorships[5].institutions[0].ror | https://ror.org/02rdpzb15 |
| authorships[5].institutions[0].type | company |
| authorships[5].institutions[0].lineage | https://openalex.org/I1299907687 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Bloomberg (United States) |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Maggie Li |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | 1Johns Hopkins Bloomberg Sch. of Public Hlth. |
| authorships[6].author.id | https://openalex.org/A5055348418 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Camille Wouters |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I1299907687 |
| authorships[6].affiliations[0].raw_affiliation_string | 1Johns Hopkins Bloomberg Sch. of Public Hlth. |
| authorships[6].institutions[0].id | https://openalex.org/I1299907687 |
| authorships[6].institutions[0].ror | https://ror.org/02rdpzb15 |
| authorships[6].institutions[0].type | company |
| authorships[6].institutions[0].lineage | https://openalex.org/I1299907687 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Bloomberg (United States) |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Camille Wouters |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | 1Johns Hopkins Bloomberg Sch. of Public Hlth. |
| authorships[7].author.id | https://openalex.org/A5069380959 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-2785-317X |
| authorships[7].author.display_name | Andrew H. Karaba |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I145311948, https://openalex.org/I6059380 |
| authorships[7].affiliations[0].raw_affiliation_string | 2Johns Hopkins Univ. Sch. of Med. |
| authorships[7].institutions[0].id | https://openalex.org/I145311948 |
| authorships[7].institutions[0].ror | https://ror.org/00za53h95 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I145311948 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | Johns Hopkins University |
| authorships[7].institutions[1].id | https://openalex.org/I6059380 |
| authorships[7].institutions[1].ror | https://ror.org/024gw2733 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I6059380 |
| authorships[7].institutions[1].country_code | US |
| authorships[7].institutions[1].display_name | University of Baltimore |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Andrew H. Karaba |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | 2Johns Hopkins Univ. Sch. of Med. |
| authorships[8].author.id | https://openalex.org/A5018624004 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-9683-8021 |
| authorships[8].author.display_name | Joel N. Blankson |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I145311948, https://openalex.org/I6059380 |
| authorships[8].affiliations[0].raw_affiliation_string | 2Johns Hopkins Univ. Sch. of Med. |
| authorships[8].institutions[0].id | https://openalex.org/I145311948 |
| authorships[8].institutions[0].ror | https://ror.org/00za53h95 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I145311948 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | Johns Hopkins University |
| authorships[8].institutions[1].id | https://openalex.org/I6059380 |
| authorships[8].institutions[1].ror | https://ror.org/024gw2733 |
| authorships[8].institutions[1].type | education |
| authorships[8].institutions[1].lineage | https://openalex.org/I6059380 |
| authorships[8].institutions[1].country_code | US |
| authorships[8].institutions[1].display_name | University of Baltimore |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Joel N. Blankson |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | 2Johns Hopkins Univ. Sch. of Med. |
| authorships[9].author.id | https://openalex.org/A5066564090 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-0517-3766 |
| authorships[9].author.display_name | Aaron A.R. Tobian |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I145311948, https://openalex.org/I6059380 |
| authorships[9].affiliations[0].raw_affiliation_string | 2Johns Hopkins Univ. Sch. of Med. |
| authorships[9].institutions[0].id | https://openalex.org/I145311948 |
| authorships[9].institutions[0].ror | https://ror.org/00za53h95 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I145311948 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | Johns Hopkins University |
| authorships[9].institutions[1].id | https://openalex.org/I6059380 |
| authorships[9].institutions[1].ror | https://ror.org/024gw2733 |
| authorships[9].institutions[1].type | education |
| authorships[9].institutions[1].lineage | https://openalex.org/I6059380 |
| authorships[9].institutions[1].country_code | US |
| authorships[9].institutions[1].display_name | University of Baltimore |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Aaron A.R. Tobian |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | 2Johns Hopkins Univ. Sch. of Med. |
| authorships[10].author.id | https://openalex.org/A5043750897 |
| authorships[10].author.orcid | https://orcid.org/0000-0003-2943-5895 |
| authorships[10].author.display_name | William A. Werbel |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I145311948, https://openalex.org/I6059380 |
| authorships[10].affiliations[0].raw_affiliation_string | 2Johns Hopkins Univ. Sch. of Med. |
| authorships[10].institutions[0].id | https://openalex.org/I145311948 |
| authorships[10].institutions[0].ror | https://ror.org/00za53h95 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I145311948 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | Johns Hopkins University |
| authorships[10].institutions[1].id | https://openalex.org/I6059380 |
| authorships[10].institutions[1].ror | https://ror.org/024gw2733 |
| authorships[10].institutions[1].type | education |
| authorships[10].institutions[1].lineage | https://openalex.org/I6059380 |
| authorships[10].institutions[1].country_code | US |
| authorships[10].institutions[1].display_name | University of Baltimore |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | William A. Werbel |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | 2Johns Hopkins Univ. Sch. of Med. |
| authorships[11].author.id | https://openalex.org/A5066093013 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-3248-1761 |
| authorships[11].author.display_name | Andrew Pekosz |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I145311948, https://openalex.org/I6059380 |
| authorships[11].affiliations[0].raw_affiliation_string | 2Johns Hopkins Univ. Sch. of Med. |
| authorships[11].affiliations[1].institution_ids | https://openalex.org/I1299907687 |
| authorships[11].affiliations[1].raw_affiliation_string | 1Johns Hopkins Bloomberg Sch. of Public Hlth. |
| authorships[11].institutions[0].id | https://openalex.org/I1299907687 |
| authorships[11].institutions[0].ror | https://ror.org/02rdpzb15 |
| authorships[11].institutions[0].type | company |
| authorships[11].institutions[0].lineage | https://openalex.org/I1299907687 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | Bloomberg (United States) |
| authorships[11].institutions[1].id | https://openalex.org/I145311948 |
| authorships[11].institutions[1].ror | https://ror.org/00za53h95 |
| authorships[11].institutions[1].type | education |
| authorships[11].institutions[1].lineage | https://openalex.org/I145311948 |
| authorships[11].institutions[1].country_code | US |
| authorships[11].institutions[1].display_name | Johns Hopkins University |
| authorships[11].institutions[2].id | https://openalex.org/I6059380 |
| authorships[11].institutions[2].ror | https://ror.org/024gw2733 |
| authorships[11].institutions[2].type | education |
| authorships[11].institutions[2].lineage | https://openalex.org/I6059380 |
| authorships[11].institutions[2].country_code | US |
| authorships[11].institutions[2].display_name | University of Baltimore |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Andrew Pekosz |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | 1Johns Hopkins Bloomberg Sch. of Public Hlth., 2Johns Hopkins Univ. Sch. of Med. |
| authorships[12].author.id | https://openalex.org/A5034561869 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-0730-5224 |
| authorships[12].author.display_name | Sabra L. Klein |
| authorships[12].countries | US |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I1299907687 |
| authorships[12].affiliations[0].raw_affiliation_string | 1Johns Hopkins Bloomberg Sch. of Public Hlth. |
| authorships[12].affiliations[1].institution_ids | https://openalex.org/I145311948, https://openalex.org/I6059380 |
| authorships[12].affiliations[1].raw_affiliation_string | 2Johns Hopkins Univ. Sch. of Med. |
| authorships[12].institutions[0].id | https://openalex.org/I1299907687 |
| authorships[12].institutions[0].ror | https://ror.org/02rdpzb15 |
| authorships[12].institutions[0].type | company |
| authorships[12].institutions[0].lineage | https://openalex.org/I1299907687 |
| authorships[12].institutions[0].country_code | US |
| authorships[12].institutions[0].display_name | Bloomberg (United States) |
| authorships[12].institutions[1].id | https://openalex.org/I145311948 |
| authorships[12].institutions[1].ror | https://ror.org/00za53h95 |
| authorships[12].institutions[1].type | education |
| authorships[12].institutions[1].lineage | https://openalex.org/I145311948 |
| authorships[12].institutions[1].country_code | US |
| authorships[12].institutions[1].display_name | Johns Hopkins University |
| authorships[12].institutions[2].id | https://openalex.org/I6059380 |
| authorships[12].institutions[2].ror | https://ror.org/024gw2733 |
| authorships[12].institutions[2].type | education |
| authorships[12].institutions[2].lineage | https://openalex.org/I6059380 |
| authorships[12].institutions[2].country_code | US |
| authorships[12].institutions[2].display_name | University of Baltimore |
| authorships[12].author_position | last |
| authorships[12].raw_author_name | Sabra L. Klein |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | 1Johns Hopkins Bloomberg Sch. of Public Hlth., 2Johns Hopkins Univ. Sch. of Med. |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/252.16/1632488/252_16.pdf |
| open_access.oa_status | bronze |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Altered antibody profiles after receipt of third dose SARS-CoV-2 mRNA vaccines in solid organ transplant recipients |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10118 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2725 |
| primary_topic.subfield.display_name | Infectious Diseases |
| primary_topic.display_name | SARS-CoV-2 and COVID-19 Research |
| related_works | https://openalex.org/W2052465442, https://openalex.org/W4200167841, https://openalex.org/W2374971639, https://openalex.org/W1991270129, https://openalex.org/W3204629868, https://openalex.org/W2381991529, https://openalex.org/W4223505415, https://openalex.org/W3164204458, https://openalex.org/W2118520178, https://openalex.org/W3185521317 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.4049/jimmunol.210.supp.252.16 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S38008053 |
| best_oa_location.source.issn | 0022-1767, 1550-6606 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0022-1767 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | The Journal of Immunology |
| best_oa_location.source.host_organization | https://openalex.org/P4320800377 |
| best_oa_location.source.host_organization_name | American Association of Immunologists |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4320800377 |
| best_oa_location.source.host_organization_lineage_names | American Association of Immunologists |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/252.16/1632488/252_16.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | The Journal of Immunology |
| best_oa_location.landing_page_url | https://doi.org/10.4049/jimmunol.210.supp.252.16 |
| primary_location.id | doi:10.4049/jimmunol.210.supp.252.16 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S38008053 |
| primary_location.source.issn | 0022-1767, 1550-6606 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0022-1767 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | The Journal of Immunology |
| primary_location.source.host_organization | https://openalex.org/P4320800377 |
| primary_location.source.host_organization_name | American Association of Immunologists |
| primary_location.source.host_organization_lineage | https://openalex.org/P4320800377 |
| primary_location.source.host_organization_lineage_names | American Association of Immunologists |
| primary_location.license | |
| primary_location.pdf_url | https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/252.16/1632488/252_16.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | The Journal of Immunology |
| primary_location.landing_page_url | https://doi.org/10.4049/jimmunol.210.supp.252.16 |
| publication_date | 2023-05-01 |
| publication_year | 2023 |
| referenced_works_count | 0 |
| abstract_inverted_index.A | 104 |
| abstract_inverted_index.a | 199 |
| abstract_inverted_index.HC | 190 |
| abstract_inverted_index.as | 26, 62, 64 |
| abstract_inverted_index.at | 80, 191 |
| abstract_inverted_index.be | 232 |
| abstract_inverted_index.in | 72, 113, 126, 182, 189, 219, 242 |
| abstract_inverted_index.no | 162 |
| abstract_inverted_index.of | 22, 33, 67, 177, 202, 239 |
| abstract_inverted_index.to | 37, 115, 124, 131, 139, 151, 234 |
| abstract_inverted_index.(S) | 110 |
| abstract_inverted_index.For | 93 |
| abstract_inverted_index.IgG | 43, 69, 111, 129, 168, 217 |
| abstract_inverted_index.NAb | 149 |
| abstract_inverted_index.The | 31, 165 |
| abstract_inverted_index.aim | 32 |
| abstract_inverted_index.and | 14, 46, 56, 60, 83, 119, 154, 180, 210, 237 |
| abstract_inverted_index.are | 213, 223 |
| abstract_inverted_index.had | 15, 145 |
| abstract_inverted_index.low | 146 |
| abstract_inverted_index.our | 194 |
| abstract_inverted_index.the | 53, 65, 68, 86, 116, 140, 152, 171, 186, 214 |
| abstract_inverted_index.two | 20 |
| abstract_inverted_index.was | 36 |
| abstract_inverted_index.BA.1 | 59, 156 |
| abstract_inverted_index.IgG1 | 209 |
| abstract_inverted_index.IgG4 | 181 |
| abstract_inverted_index.NAb. | 164 |
| abstract_inverted_index.also | 144 |
| abstract_inverted_index.dose | 88, 106, 201 |
| abstract_inverted_index.from | 76, 122 |
| abstract_inverted_index.live | 47, 147 |
| abstract_inverted_index.mRNA | 24, 90, 203 |
| abstract_inverted_index.many | 159 |
| abstract_inverted_index.more | 16 |
| abstract_inverted_index.pre- | 123 |
| abstract_inverted_index.than | 138, 226 |
| abstract_inverted_index.that | 197 |
| abstract_inverted_index.this | 34 |
| abstract_inverted_index.well | 63 |
| abstract_inverted_index.were | 78, 98, 135 |
| abstract_inverted_index.with | 28, 100, 158, 244 |
| abstract_inverted_index.(D3). | 92 |
| abstract_inverted_index.(HC). | 103 |
| abstract_inverted_index.(NAb) | 51 |
| abstract_inverted_index.BA.5, | 61 |
| abstract_inverted_index.IgG1, | 178 |
| abstract_inverted_index.IgG3, | 179, 211 |
| abstract_inverted_index.SOTRs | 77, 143 |
| abstract_inverted_index.Serum | 74 |
| abstract_inverted_index.after | 19 |
| abstract_inverted_index.doses | 21, 238 |
| abstract_inverted_index.given | 233 |
| abstract_inverted_index.lower | 11, 137, 225 |
| abstract_inverted_index.organ | 5 |
| abstract_inverted_index.solid | 4 |
| abstract_inverted_index.still | 224 |
| abstract_inverted_index.study | 35 |
| abstract_inverted_index.these | 221 |
| abstract_inverted_index.third | 87, 105 |
| abstract_inverted_index.virus | 48, 148 |
| abstract_inverted_index.which | 184, 212 |
| abstract_inverted_index.while | 198 |
| abstract_inverted_index.Anti-S | 128 |
| abstract_inverted_index.SOTRs, | 183, 220 |
| abstract_inverted_index.SOTRs. | 73, 127 |
| abstract_inverted_index.anti-S | 167 |
| abstract_inverted_index.having | 161 |
| abstract_inverted_index.immune | 247 |
| abstract_inverted_index.levels | 66 |
| abstract_inverted_index.people | 243 |
| abstract_inverted_index.should | 231 |
| abstract_inverted_index.strain | 55, 174 |
| abstract_inverted_index.titers | 112, 150 |
| abstract_inverted_index.90-days | 84 |
| abstract_inverted_index.IgG1-4, | 71 |
| abstract_inverted_index.Omicron | 57, 120, 132, 155 |
| abstract_inverted_index.against | 52, 170 |
| abstract_inverted_index.binding | 44 |
| abstract_inverted_index.booster | 200 |
| abstract_inverted_index.healthy | 101 |
| abstract_inverted_index.induces | 205 |
| abstract_inverted_index.post-D3 | 125 |
| abstract_inverted_index.samples | 75 |
| abstract_inverted_index.several | 94 |
| abstract_inverted_index.strain. | 142 |
| abstract_inverted_index.vaccine | 54, 118, 141, 153, 173, 204 |
| abstract_inverted_index.(SOTRs), | 8 |
| abstract_inverted_index.30-days, | 82 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.COVID-19 | 23, 89, 240 |
| abstract_inverted_index.analyzed | 79 |
| abstract_inverted_index.antibody | 12, 40, 96, 206 |
| abstract_inverted_index.compared | 27, 99 |
| abstract_inverted_index.controls | 102 |
| abstract_inverted_index.dominant | 215 |
| abstract_inverted_index.findings | 195 |
| abstract_inverted_index.however, | 134 |
| abstract_inverted_index.post-D3. | 192 |
| abstract_inverted_index.profiles | 188 |
| abstract_inverted_index.response | 114 |
| abstract_inverted_index.severely | 245 |
| abstract_inverted_index.subclass | 187 |
| abstract_inverted_index.systems. | 248 |
| abstract_inverted_index.vaccines | 91, 241 |
| abstract_inverted_index.variant, | 157 |
| abstract_inverted_index.variants | 121 |
| abstract_inverted_index.Together, | 193 |
| abstract_inverted_index.antiviral | 216 |
| abstract_inverted_index.consisted | 176 |
| abstract_inverted_index.developed | 9 |
| abstract_inverted_index.different | 235 |
| abstract_inverted_index.following | 85 |
| abstract_inverted_index.including | 3, 42, 208 |
| abstract_inverted_index.increased | 108 |
| abstract_inverted_index.measures, | 95 |
| abstract_inverted_index.patients, | 2 |
| abstract_inverted_index.resembled | 185 |
| abstract_inverted_index.responses | 13, 97, 130, 222 |
| abstract_inverted_index.vaccines, | 25 |
| abstract_inverted_index.variants, | 58, 133 |
| abstract_inverted_index.SARS-CoV-2 | 117, 172 |
| abstract_inverted_index.Therefore, | 229 |
| abstract_inverted_index.anti-spike | 109 |
| abstract_inverted_index.antibodies | 45, 50, 169 |
| abstract_inverted_index.detectable | 163 |
| abstract_inverted_index.illustrate | 196 |
| abstract_inverted_index.infections | 18 |
| abstract_inverted_index.recipients | 7 |
| abstract_inverted_index.responses, | 41, 207 |
| abstract_inverted_index.transplant | 6 |
| abstract_inverted_index.compromised | 246 |
| abstract_inverted_index.individuals | 160 |
| abstract_inverted_index.subclasses, | 70, 218 |
| abstract_inverted_index.vaccination | 107 |
| abstract_inverted_index.breakthrough | 17 |
| abstract_inverted_index.characterize | 38 |
| abstract_inverted_index.formulations | 236 |
| abstract_inverted_index.individuals. | 30, 228 |
| abstract_inverted_index.neutralizing | 49 |
| abstract_inverted_index.consideration | 230 |
| abstract_inverted_index.predominantly | 175 |
| abstract_inverted_index.significantly | 10, 136 |
| abstract_inverted_index.immunocompetent | 29, 227 |
| abstract_inverted_index.vaccine-induced | 39 |
| abstract_inverted_index.Immunosuppressed | 1 |
| abstract_inverted_index.pre-vaccination, | 81 |
| abstract_inverted_index.subclass-specific | 166 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 13 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.800000011920929 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.15334753 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |