Altered leptin signaling and attenuated cardiac vagal activity in rats with type 2 diabetes Article Swipe
Anthony J. Evans
,
Huiyin Tu
,
Yulong Li
,
Boris Shabaltiy
,
L. Whitney
,
Kassidy Carpenter
,
Yu‐Long Li
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fphys.2025.1547901
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fphys.2025.1547901
Introduction The leading cause of death in type 2 diabetes mellitus (T2DM) patients is cardiovascular-related events, including myocardial infraction-induced ventricular arrhythmia. Previous studies have shown that T2DM-induced functional remodeling of cardiac vagal postganglionic (CVP) neurons contributes to ventricular arrhythmogenesis. As leptin resistance is common in T2DM patients, and CVP neurons are located in epicardial adipose pads, a tissue that secretes leptin, in this study we aimed to elucidate a correlation between leptin resistance and CVP neuronal dysfunction in T2DM. Methods A high fat-diet/low dose streptozotocin-induced T2DM rat model was used in this study to characterize T2DM-induced alterations in cardiac parasympathetic tone, determined by changes in baroreflex sensitivity and CVP neuronal excitability. The impact of leptin resistance on CVP neurons was also studied by examining the expression of leptin in epicardial adipose pads, and leptin receptors and uncoupling protein 2 (UCP2) in CVP neurons. Results T2DM rats exhibited diminished baroreflex sensitivity, and decreased CVP neuronal excitability, demonstrated by a reduced frequency of action potentials, diminished nAChR currents, and an attenuated response to nicotine stimulation. Additionally, compared to sham animals, the expression of leptin receptors and UCP2 in CVP neurons was reduced as early as 4 weeks post-T2DM although the leptin levels in epicardial adipose pads was increased during the progression of T2DM, which demonstrated the occurrence of leptin resistance in T2DM CVP neurons. Conclusion Cardiac parasympathetic dysfunction in T2DM rats is due, in part, to functional remodeling of CVP neurons. As leptin resistance develops as early as 4 weeks post-T2DM induction, diminished leptin receptors-UCP2 signaling may contribute to CVP neuronal dysregulation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fphys.2025.1547901
- https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1547901/pdf
- OA Status
- gold
- Cited By
- 1
- References
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- Related Works
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- OpenAlex ID
- https://openalex.org/W4407982338
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4407982338Canonical identifier for this work in OpenAlex
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https://doi.org/10.3389/fphys.2025.1547901Digital Object Identifier
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Altered leptin signaling and attenuated cardiac vagal activity in rats with type 2 diabetesWork title
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articleOpenAlex work type
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-02-26Full publication date if available
- Authors
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Anthony J. Evans, Huiyin Tu, Yulong Li, Boris Shabaltiy, L. Whitney, Kassidy Carpenter, Yu‐Long LiList of authors in order
- Landing page
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https://doi.org/10.3389/fphys.2025.1547901Publisher landing page
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https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1547901/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1547901/pdfDirect OA link when available
- Concepts
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Internal medicine, Endocrinology, Medicine, Leptin, Type 2 diabetes, Diabetes mellitus, ObesityTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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